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PDCD6IP

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Programmed cell death 6-interacting protein also known as ALIX is a protein that in humans is encoded by the PDCD6IP gene.{{cite journal |vauthors=Vito P, Pellegrini L, Guiet C, D'Adamio L | title = Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction | journal = J Biol Chem | volume = 274 | issue = 3 | pages = 1533–40 |date=Feb 1999 | pmid = 9880530 | doi =10.1074/jbc.274.3.1533 | doi-access = free }}{{cite web | title = Entrez Gene: PDCD6IP programmed cell death 6 interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10015}}

This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death.

Function

PDCD6IP protein is part of ESCRT pathway. It participates in the membrane scission of the revers topology budding and participates in multivesicular body formation.{{cite journal |last1=Vietri |first1=Marina |last2=Radulovic |first2=Maja |last3=Stenmark |first3=Harald |title=The many functions of ESCRTs |journal=Nature Reviews Molecular Cell Biology |date=January 2020 |volume=21 |issue=1 |pages=25–42 |doi=10.1038/s41580-019-0177-4|pmid=31705132 |s2cid=207939465 }} It is also vital at the later stages and for successful completion of cytokinesis.{{cite journal |last1=Carlton |first1=Jez G. |last2=Martin-Serrano |first2=Juan |title=Parallels Between Cytokinesis and Retroviral Budding: A Role for the ESCRT Machinery |journal=Science |date=29 June 2007 |volume=316 |issue=5833 |pages=1908–1912 |doi=10.1126/science.1143422|pmid=17556548 |bibcode=2007Sci...316.1908C |s2cid=29191843 |url=https://zenodo.org/record/896126 |doi-access=free }}

Interactions

PDCD6IP has been shown to interact with PDCD6.{{cite journal |last=Satoh |first=Hirokazu |author2=Shibata Hideki |author3=Nakano Yoshimi |author4=Kitaura Yasuyuki |author5=Maki Masatoshi |date=Mar 2002 |title=ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue=5 |pages=1166–72 |location = United States| issn = 0006-291X| pmid = 11883939 |doi = 10.1006/bbrc.2002.6600 }} The V domain of PDCD6IP recognises Short linear motif LYPxLxxL and this motif is mimicked by p6 late domain of HIV and related viruses which facilitates viral hijacking of ESCRT pathway and consequential budding of viral particles.{{cite journal |last1=Votteler |first1=Jörg |last2=Sundquist |first2=Wesley I. |title=Virus Budding and the ESCRT Pathway |journal=Cell Host & Microbe |date=September 2013 |volume=14 |issue=3 |pages=232–241 |doi=10.1016/j.chom.2013.08.012|pmid=24034610 |pmc=3819203 }}

References

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Further reading

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  • {{cite journal |vauthors=Wood JD, Yuan J, Margolis RL, etal |title=Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins |journal=Mol. Cell. Neurosci. |volume=11 |issue= 3 |pages= 149–60 |year= 1998 |pmid= 9647693 |doi= 10.1006/mcne.1998.0677 |s2cid=20003277 |doi-access=free }}
  • {{cite journal |vauthors=Missotten M, Nichols A, Rieger K, Sadoul R |title=Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein |journal=Cell Death Differ. |volume=6 |issue= 2 |pages= 124–9 |year= 1999 |pmid= 10200558 |doi= 10.1038/sj.cdd.4400456 |doi-access= free }}
  • {{cite journal |vauthors=Nagase T, Kikuno R, Ishikawa KI, etal |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 1 |pages= 65–73 |year= 2000 |pmid= 10718198 |doi=10.1093/dnares/7.1.65 |doi-access=free }}
  • {{cite journal |vauthors=Wu Y, Pan S, Che S, etal |title=Overexpression of Hp95 induces G1 phase arrest in confluent HeLa cells |journal=Differentiation |volume=67 |issue= 4–5 |pages= 139–53 |year= 2002 |pmid= 11683497 |doi=10.1046/j.1432-0436.2001.670406.x }}
  • {{cite journal |vauthors=Satoh H, Shibata H, Nakano Y, etal |title=ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue= 5 |pages= 1166–72 |year= 2002 |pmid= 11883939 |doi= 10.1006/bbrc.2002.6600 }}
  • {{cite journal |vauthors=Chatellard-Causse C, Blot B, Cristina N, etal |title=Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 29108–15 |year= 2002 |pmid= 12034747 |doi= 10.1074/jbc.M204019200 |doi-access= free }}
  • {{cite journal |vauthors=Wu Y, Pan S, Luo W, etal |title=Hp95 promotes anoikis and inhibits tumorigenicity of HeLa cells |journal=Oncogene |volume=21 |issue= 44 |pages= 6801–8 |year= 2002 |pmid= 12360406 |doi= 10.1038/sj.onc.1205849 |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Vincent O, Rainbow L, Tilburn J, etal |title=YPXL/I is a protein interaction motif recognized by aspergillus PalA and its human homologue, AIP1/Alix |journal=Mol. Cell. Biol. |volume=23 |issue= 5 |pages= 1647–55 |year= 2003 |pmid= 12588984 |doi=10.1128/MCB.23.5.1647-1655.2003 | pmc=151718 }}
  • {{cite journal |vauthors=Schmidt MH, Chen B, Randazzo LM, Bogler O |title=SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion |journal=J. Cell Sci. |volume=116 |issue= Pt 14 |pages= 2845–55 |year= 2004 |pmid= 12771190 |doi= 10.1242/jcs.00522 |s2cid=6863972 |doi-access= }}
  • {{cite journal |vauthors=Katoh K, Shibata H, Suzuki H, etal |title=The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 39104–13 |year= 2003 |pmid= 12860994 |doi= 10.1074/jbc.M301604200 |doi-access= free }}
  • {{cite journal |vauthors=Leonard D, Ajuh P, Lamond AI, Legerski RJ |title=hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 4 |pages= 793–801 |year= 2003 |pmid= 12927788 |doi=10.1016/S0006-291X(03)01486-4 }}
  • {{cite journal |vauthors=Strack B, Calistri A, Craig S, etal |title=AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding |journal=Cell |volume=114 |issue= 6 |pages= 689–99 |year= 2003 |pmid= 14505569 |doi=10.1016/S0092-8674(03)00653-6 |s2cid=10733770 |doi-access=free }}
  • {{cite journal |vauthors=von Schwedler UK, Stuchell M, Müller B, etal |title=The protein network of HIV budding |journal=Cell |volume=114 |issue= 6 |pages= 701–13 |year= 2003 |pmid= 14505570 |doi=10.1016/S0092-8674(03)00714-1 |s2cid=16894972 |doi-access=free }}
  • {{cite journal |vauthors=Martin-Serrano J, Yarovoy A, Perez-Caballero D, etal |title=Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 21 |pages= 12414–9 |year= 2003 |pmid= 14519844 |doi= 10.1073/pnas.2133846100 | pmc=218772 |bibcode=2003PNAS..10012414M |doi-access=free }}
  • {{cite journal |vauthors=Peck JW, Bowden ET, Burbelo PD |title=Structure and function of human Vps20 and Snf7 proteins |journal=Biochem. J. |volume=377 |issue= Pt 3 |pages= 693–700 |year= 2004 |pmid= 14583093 |doi= 10.1042/BJ20031347 | pmc=1223912 }}
  • {{cite journal |vauthors=Katoh K, Shibata H, Hatta K, Maki M |title=CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms |journal=Arch. Biochem. Biophys. |volume=421 |issue= 1 |pages= 159–65 |year= 2004 |pmid= 14678797 |doi=10.1016/j.abb.2003.09.038 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Matsuo H, Chevallier J, Mayran N, etal |title=Role of LBPA and Alix in multivesicular liposome formation and endosome organization |journal=Science |volume=303 |issue= 5657 |pages= 531–4 |year= 2004 |pmid= 14739459 |doi= 10.1126/science.1092425 |bibcode=2004Sci...303..531M |s2cid=36353407 }}

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External links

  • {{UCSC genome browser|PDCD6IP}}
  • {{UCSC gene details|PDCD6IP}}

{{PDB Gallery|geneid=10015}}

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