PDCD7
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Programmed cell death protein 7 is a protein that in humans is encoded by the PDCD7 gene.{{cite journal | vauthors = Park EJ, Kim JH, Seong RH, Kim CG, Park SD, Hong SH | title = Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells | journal = Nucleic Acids Res | volume = 27 | issue = 6 | pages = 1524–30 |date=Apr 1999 | pmid = 10037816 | pmc = 148348 | doi =10.1093/nar/27.6.1524 }}{{cite web | title = Entrez Gene: PDCD7 programmed cell death 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10081| accessdate = }}
This gene encodes a protein with sequence similarity to a mouse protein originally identified in embryonic stem cells. In mouse T-cell lines, this protein appears to be related to glucocorticoid- and staurine-induced apoptotic pathways, and to be linked to ceramide-mediated signalling. These observations suggest that this gene product is involved in specific apoptotic processes in T-cells.
References
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Further reading
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- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
- {{cite journal |vauthors=Will CL, Schneider C, Hossbach M, etal |title=The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome |journal=RNA |volume=10 |issue= 6 |pages= 929–41 |year= 2004 |pmid= 15146077 |doi=10.1261/rna.7320604 | pmc=1370585 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
- {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
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External links
- {{UCSC genome browser|PDCD7}}
- {{UCSC gene details|PDCD7}}
{{gene-15-stub}}