PDE8A
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A is an enzyme that in humans is encoded by the PDE8A gene.{{cite journal | vauthors = Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB | title = Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase | journal = Biochem Biophys Res Commun | volume = 246 | issue = 3 | pages = 570–577 |date=Jul 1998 | pmid = 9618252 | doi = 10.1006/bbrc.1998.8684 }}{{cite web | title = Entrez Gene: PDE8A phosphodiesterase 8A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5151}} Work by Sebastiaan Bol et al. showed that 5 different transcript variants and their corresponding isoforms are expressed in human macrophages, and suggests that this protein may be required by HIV-1 for its replication.{{cite journal | vauthors = Bol SM, Booiman T, Bunnik EM, Moerland PD, van Dort K, ((Strauss JF III)), Sieberer M, Schuitemaker H, Kootstra NA, van 't Wout AB | title = Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages | journal = Virology |date=Sep 2011 | pmid = 21920574 | doi=10.1016/j.virol.2011.08.013 | volume=420 | issue=1 | pages=32–42| doi-access=free }}
References
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Further reading
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- {{cite journal | author=Bass BL |title=RNA editing by adenosine deaminases that act on RNA. |journal=Annu. Rev. Biochem. |volume=71 |pages= 817–846 |year= 2002 |pmid= 12045112 |doi= 10.1146/annurev.biochem.71.110601.135501 | pmc=1823043 }}
- {{cite journal |vauthors=Zauli G, Milani D, Mirandola P, etal |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. |journal=FASEB J. |volume=15 |issue= 2 |pages= 483–491 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com |doi-access=free |s2cid=26315564 }}
- {{cite journal |vauthors=Glavas NA, Ostenson C, Schaefer JB, etal |title=T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 11 |pages= 6319–6324 |year= 2001 |pmid= 11371644 |doi= 10.1073/pnas.101131098 | pmc=33466 |bibcode=2001PNAS...98.6319G |doi-access=free }}
- {{cite journal | vauthors=Wang P, Wu P, Egan RW, Billah MM |title=Human phosphodiesterase 8A splice variants: cloning, gene organization, and tissue distribution. |journal=Gene |volume=280 |issue= 1–2 |pages= 183–194 |year= 2002 |pmid= 11738832 |doi=10.1016/S0378-1119(01)00783-1 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Gamanuma M, Yuasa K, Sasaki T, etal |title=Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans |journal=Cell. Signal. |volume=15 |issue= 6 |pages= 565–574 |year= 2003 |pmid= 12681444 |doi=10.1016/S0898-6568(02)00146-8 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal | vauthors=Wu P, Wang P |title=Per-Arnt-Sim domain-dependent association of cAMP-phosphodiesterase 8A1 with IkappaB proteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 51 |pages= 17634–17639 |year= 2005 |pmid= 15596729 |doi= 10.1073/pnas.0407649101 | pmc=539753 |doi-access=free }}
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