PDE9A
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A is an enzyme that in humans is encoded by the PDE9A gene.{{cite journal | vauthors = Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB | title = Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase | journal = J Biol Chem | volume = 273 | issue = 25 | pages = 15559–64 |date=Jul 1998 | pmid = 9624146 | doi =10.1074/jbc.273.25.15559 | doi-access = free }}{{cite web | title = Entrez Gene: PDE9A phosphodiesterase 9A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5152}}
The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene.
Inhibitors
- BAY 73-6691
- PF-04447943{{cite journal |vauthors=Verhoest PR, Fonseca KR, Hou X, etal |title=Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive disorders |journal=J. Med. Chem. |volume=55 |issue=21 |pages=9045–54 |year=2012 |pmid=22780914 |doi=10.1021/jm3007799 }}{{cite journal |vauthors=Hutson PH, Finger EN, Magliaro BC, etal |title=The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents |journal=Neuropharmacology |volume=61 |issue=4 |pages=665–76 |year=2011 |pmid=21619887 |doi=10.1016/j.neuropharm.2011.05.009 |s2cid=143527784 }}
See also
References
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Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Guipponi M, Scott HS, Kudoh J, etal |title=Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene (PDE9A) that maps to 21q22.3: alternative splicing of mRNA transcripts, genomic structure and sequence |journal=Hum. Genet. |volume=103 |issue= 4 |pages= 386–92 |year= 1998 |pmid= 9856478 |doi=10.1007/s004390050838 |s2cid=24883234 }}
- {{cite journal |vauthors=Hattori M, Fujiyama A, Taylor TD, etal |title=The DNA sequence of human chromosome 21 |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 |bibcode=2000Natur.405..311H |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | vauthors=Rentero C, Monfort A, Puigdomènech P |title=Identification and distribution of different mRNA variants produced by differential splicing in the human phosphodiesterase 9A gene |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 3 |pages= 686–92 |year= 2003 |pmid= 12565835 |doi=10.1016/S0006-291X(03)00021-4 }}
- {{cite journal | vauthors=Wang P, Wu P, Egan RW, Billah MM |title=Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants |journal=Gene |volume=314 |pages= 15–27 |year= 2003 |pmid= 14527714 |doi=10.1016/S0378-1119(03)00733-9 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Huai Q, Wang H, Zhang W, etal |title=Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 26 |pages= 9624–9 |year= 2004 |pmid= 15210993 |doi= 10.1073/pnas.0401120101 | pmc=470725 |bibcode=2004PNAS..101.9624H |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
- {{cite journal |vauthors=Hu YH, Warnatz HJ, Vanhecke D, etal |title=Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins |journal=BMC Genomics |volume=7|pages= 155 |year= 2006 |pmid= 16780588 |doi= 10.1186/1471-2164-7-155 | pmc=1526728 |doi-access=free }}
- {{cite journal | vauthors=Rentero C, Puigdomènech P |title=Specific use of start codons and cellular localization of splice variants of human phosphodiesterase 9A gene |journal=BMC Mol. Biol. |volume=7|pages= 39 |year= 2007 |pmid= 17090334 |doi= 10.1186/1471-2199-7-39 | pmc=1647287 |doi-access=free }}
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