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PDLIM5

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

PDZ and LIM domain protein 5 is a protein that in humans is encoded by the PDLIM5 gene.{{cite journal |vauthors=Wu M, Li Y, Ji C, Xu J, Zheng H, Zou X, Gu S, Lou Y, Xie Y, Mao Y | title = Cloning and identification of a novel human gene PDLIM5, a homolog of AD-associated neuronal thread protein (AD7c-NTP) | journal = DNA Seq | volume = 15 | issue = 2 | pages = 144–7 |date=September 2004 | pmid = 15346770 | doi =10.1080/10425170310001656756 | s2cid = 36916587 }}{{cite web | title = Entrez Gene: PDLIM5 PDZ and LIM domain 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10611}}

The protein encoded by this gene is a LIM domain protein. LIM domains are cysteine-rich double zinc fingers composed of 50 to 60 amino acids that are involved in protein-protein interactions. LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes. The proteins are involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis. The encoded protein is also a member of the Enigma class of proteins, a family of proteins that possess a 100-amino acid PDZ domain in the N-terminus and 1 to 3 LIM domains in the C terminus. Multiple transcript variants encoding different isoforms have been found for this gene, although not all of them have been fully characterized.

Interactions

PDLIM5 has been shown to interact with PRKCB1.{{cite journal |last=Kuroda |first=S |author2=Tokunaga C |author3=Kiyohara Y |author4=Higuchi O |author5=Konishi H |author6=Mizuno K |author7=Gill G N |author8=Kikkawa U |date=December 1996 |title=Protein-protein interaction of zinc finger LIM domains with protein kinase C |journal=J. Biol. Chem. |volume=271 |issue=49 |pages=31029–32 | issn = 0021-9258| pmid = 8940095 |doi=10.1074/jbc.271.49.31029 |doi-access=free }}

References

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Further reading

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  • {{cite journal |vauthors=Sudo K, Chinen K, Nakamura Y |title=2058 expressed sequence tags (ESTs) from a human fetal lung cDNA library |journal=Genomics |volume=24 |issue= 2 |pages= 276–9 |year= 1995 |pmid= 7698749 |doi= 10.1006/geno.1994.1616 }}
  • {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
  • {{cite journal | author=Kuroda S |title=Protein-protein interaction of zinc finger LIM domains with protein kinase C |journal=J. Biol. Chem. |volume=271 |issue= 49 |pages= 31029–32 |year= 1997 |pmid= 8940095 |doi=10.1074/jbc.271.49.31029 |name-list-style=vanc| author2=Tokunaga C | author3=Kiyohara Y | display-authors=3 | last4=Higuchi | first4=O | last5=Konishi | first5=H | last6=Mizuno | first6=K | last7=Gill | first7=GN | last8=Kikkawa | first8=U | doi-access=free }}
  • {{cite journal | author=Ueki N |title=Isolation, tissue expression, and chromosomal assignment of a human LIM protein gene, showing homology to rat enigma homologue (ENH) |journal=J. Hum. Genet. |volume=44 |issue= 4 |pages= 256–60 |year= 1999 |pmid= 10429367 |doi=10.1007/s100380050155 |name-list-style=vanc| author2=Seki N | author3=Yano K | display-authors=3 | last4=Masuho | first4=Yasuhiko | last5=Saito | first5=Toshiyuki | last6=Muramatsu | first6=M. | doi-access=free }}
  • {{cite journal | author=Nakagawa N |title=ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific protein, associates with cytoskeletal proteins through the PDZ domain |journal=Biochem. Biophys. Res. Commun. |volume=272 |issue= 2 |pages= 505–12 |year= 2000 |pmid= 10833443 |doi= 10.1006/bbrc.2000.2787 |name-list-style=vanc| author2=Hoshijima M | author3=Oyasu M | display-authors=3 | last4=Saito | first4=N | last5=Tanizawa | first5=K | last6=Kuroda | first6=S }}
  • {{cite journal |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
  • {{cite journal | author=Wiemann S |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 |name-list-style=vanc| author2=Weil B | author3=Wellenreuther R | display-authors=3 | last4=Gassenhuber | first4=J | last5=Glassl | first5=S | last6=Ansorge | first6=W | last7=Böcher | first7=M | last8=Blöcker | first8=H | last9=Bauersachs | first9=S }}
  • {{cite journal | author=Simpson JC |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 |name-list-style=vanc| author2=Wellenreuther R | author3=Poustka A | display-authors=3 | last4=Pepperkok | first4=R | last5=Wiemann | first5=S }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M|doi-access=free }}
  • {{cite journal | author=Maeno-Hikichi Y |title=A PKC epsilon-ENH-channel complex specifically modulates N-type Ca2+ channels |journal=Nat. Neurosci. |volume=6 |issue= 5 |pages= 468–75 |year= 2003 |pmid= 12665800 |doi= 10.1038/nn1041 |name-list-style=vanc| author2=Chang S | author3=Matsumura K | display-authors=3 | last4=Lai | first4=Meizan | last5=Lin | first5=Hong | last6=Nakagawa | first6=Noritaka | last7=Kuroda | first7=Shun'Ichi | last8=Zhang | first8=Ji-Fang |s2cid=19964052 }}
  • {{cite journal | author=Iwamoto K |title=Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders |journal=Mol. Psychiatry |volume=9 |issue= 4 |pages= 406–16 |year= 2004 |pmid= 14743183 |doi= 10.1038/sj.mp.4001437 |name-list-style=vanc| author2=Kakiuchi C | author3=Bundo M | display-authors=3 | last4=Ikeda | first4=K | last5=Kato | first5=T |doi-access=free }}
  • {{cite journal | author=Petroziello J |title=Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer |journal=Oncogene |volume=23 |issue= 46 |pages= 7734–45 |year= 2004 |pmid= 15334068 |doi= 10.1038/sj.onc.1207921 |name-list-style=vanc| author2=Yamane A | author3=Westendorf L | display-authors=3 | last4=Thompson | first4=Melissa | last5=McDonagh | first5=Charlotte | last6=Cerveny | first6=Charles | last7=Law | first7=Che-Leung | last8=Wahl | first8=Alan | last9=Carter | first9=Paul | doi-access=free }}
  • {{cite journal | author=Iwamoto K |title=Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia |journal=J. Hum. Genet. |volume=49 |issue= 5 |pages= 227–31 |year= 2004 |pmid= 15362566 |doi= 10.1007/s10038-004-0136-5 |name-list-style=vanc| author2=Bundo M | author3=Washizuka S | display-authors=3 | last4=Kakiuchi | first4=Chihiro | last5=Kato | first5=Tadafumi |doi-access=free }}
  • {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | author=Wiemann S |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 |name-list-style=vanc| author2=Arlt D | author3=Huber W | display-authors=3 | last4=Wellenreuther | first4=R | last5=Schleeger | first5=S | last6=Mehrle | first6=A | last7=Bechtel | first7=S | last8=Sauermann | first8=M | last9=Korf | first9=U }}
  • {{cite journal |vauthors=Niederländer N, Fayein NA, Auffray C, Pomiès P |title=Characterization of a new human isoform of the enigma homolog family specifically expressed in skeletal muscle |journal=Biochem. Biophys. Res. Commun. |volume=325 |issue= 4 |pages= 1304–11 |year= 2005 |pmid= 15555569 |doi= 10.1016/j.bbrc.2004.10.178 }}
  • {{cite journal | author=Kato T |title=Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia |journal=Mol. Psychiatry |volume=10 |issue= 11 |pages= 1045–55 |year= 2005 |pmid= 16044170 |doi= 10.1038/sj.mp.4001719 |name-list-style=vanc| author2=Iwayama Y | author3=Kakiuchi C | display-authors=3 | last4=Iwamoto | first4=K | last5=Yamada | first5=K | last6=Minabe | first6=Y | last7=Nakamura | first7=K | last8=Mori | first8=N | last9=Fujii | first9=K | doi-access=free }}
  • {{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-style=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija |bibcode=2005Natur.437.1173R|s2cid=4427026 }}
  • {{cite journal | author=Horiuchi Y |title=A polymorphism in the PDLIM5 gene associated with gene expression and schizophrenia |journal=Biol. Psychiatry |volume=59 |issue= 5 |pages= 434–9 |year= 2006 |pmid= 16213469 |doi= 10.1016/j.biopsych.2005.07.041 |name-list-style=vanc| author2=Arai M | author3=Niizato K | display-authors=3 | last4=Iritani | first4=Shyuji | last5=Noguchi | first5=Emiko | last6=Ohtsuki | first6=Tsuyuka | last7=Koga | first7=Minori | last8=Kato | first8=Tadafumi | last9=Itokawa | first9=Masanari |s2cid=22930796 }}

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{{PDB Gallery|geneid=10611}}

Category:Biology of bipolar disorder