PDSS2

The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis.

It may be associated with Coenzyme Q10 deficiency.{{OMIM|607426}}

• PDSS1

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• {{cite journal |vauthors=Cui TZ, Kaino T, Kawamukai M |title=A subunit of decaprenyl diphosphate synthase stabilizes octaprenyl diphosphate synthase in Escherichia coli by forming a high-molecular weight complex. |journal=FEBS Lett. |volume=584 |issue= 4 |pages= 652–6 |year= 2010 |pmid= 20051244 |doi= 10.1016/j.febslet.2009.12.029 |s2cid=41737114 |doi-access=free }}
• {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |doi-access=free }}
• {{cite journal |vauthors=Saiki R, Nagata A, Kainou T, etal |title=Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans. |journal=FEBS J. |volume=272 |issue= 21 |pages= 5606–22 |year= 2005 |pmid= 16262699 |doi= 10.1111/j.1742-4658.2005.04956.x |s2cid=13735213 |doi-access=free }}
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• {{cite journal |vauthors=Chen P, Zhao SH, Chu YL, etal |title=Anticancer activity of PDSS2, prenyl diphosphate synthase, subunit 2, in gastric cancer tissue and the SGC7901 cell line. |journal=Anticancer Drugs |volume=20 |issue= 2 |pages= 141–8 |year= 2009 |pmid= 19209031 |doi= 10.1097/CAD.0b013e32832016a9 |s2cid=19932575 }}
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• {{cite journal |vauthors=Bailey SD, Xie C, Do R, etal |title=Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. |journal=Diabetes Care |volume=33 |issue= 10 |pages= 2250–3 |year= 2010 |pmid= 20628086 |doi= 10.2337/dc10-0452 |pmc=2945168}}

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{{NLM content}}

{{Alkyl and aryl transferases}}

{{Enzymes}}

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Category:EC 2.5.1

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