PEX10

Peroxisome biogenesis factor 10 is involved in import of peroxisomal matrix proteins. This protein localizes to the peroxisomal membrane.

Mutations in this gene result in phenotypes within the Zellweger spectrum of peroxisomal biogenesis disorders, ranging from neonatal adrenoleukodystrophy to Zellweger syndrome.

PEX10 has been shown to interact with PEX12{{cite journal | vauthors = Chang CC, Warren DS, Sacksteder KA, Gould SJ | title = PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import | journal = J. Cell Biol. | volume = 147 | issue = 4 | pages = 761–74 |date=November 1999 | pmid = 10562279 | pmc = 2156163 | doi = 10.1083/jcb.147.4.761 }}{{cite journal | vauthors = Okumoto K, Abe I, Fujiki Y | title = Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p | journal = J. Biol. Chem. | volume = 275 | issue = 33 | pages = 25700–10 |date=August 2000 | pmid = 10837480 | doi = 10.1074/jbc.M003303200 | doi-access = free }} and PEX19.{{cite journal | vauthors = Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ | title = PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis | journal = J. Cell Biol. | volume = 148 | issue = 5 | pages = 931–44 |date=March 2000 | pmid = 10704444 | pmc = 2174547 | doi = 10.1083/jcb.148.5.931 }}{{cite journal | vauthors = Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP | title = Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences | journal = Mol. Cell. Biol. | volume = 21 | issue = 13 | pages = 4413–24 |date=July 2001 | pmid = 11390669 | pmc = 87101 | doi = 10.1128/MCB.21.13.4413-4424.2001 }}

{{Reflist}}

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• {{Cite journal |vauthors=Okumoto K, Itoh R, Shimozawa N, etal |title=Mutations in PEX10 is the cause of Zellweger peroxisome deficiency syndrome of complementation group B. |journal=Hum. Mol. Genet. |volume=7 |issue= 9 |pages= 1399–405 |year= 1998 |pmid= 9700193 |doi=10.1093/hmg/7.9.1399 |doi-access=free }}
• {{Cite journal | vauthors=South ST, Gould SJ |title=Peroxisome synthesis in the absence of preexisting peroxisomes. |journal=J. Cell Biol. |volume=144 |issue= 2 |pages= 255–66 |year= 1999 |pmid= 9922452 |doi=10.1083/jcb.144.2.255 | pmc=2132891 }}
• {{Cite journal | vauthors=Chang CC, Warren DS, Sacksteder KA, Gould SJ |title=PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import. |journal=J. Cell Biol. |volume=147 |issue= 4 |pages= 761–74 |year= 1999 |pmid= 10562279 |doi=10.1083/jcb.147.4.761 | pmc=2156163 }}
• {{Cite journal |vauthors=Sacksteder KA, Jones JM, South ST, etal |title=PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. |journal=J. Cell Biol. |volume=148 |issue= 5 |pages= 931–44 |year= 2000 |pmid= 10704444 |doi=10.1083/jcb.148.5.931 | pmc=2174547 }}
• {{Cite journal | vauthors=Okumoto K, Abe I, Fujiki Y |title=Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25700–10 |year= 2000 |pmid= 10837480 |doi= 10.1074/jbc.M003303200 |doi-access= free }}
• {{Cite journal | vauthors=Warren DS, Wolfe BD, Gould SJ |title=Phenotype-genotype relationships in PEX10-deficient peroxisome biogenesis disorder patients. |journal=Hum. Mutat. |volume=15 |issue= 6 |pages= 509–21 |year= 2000 |pmid= 10862081 |doi= 10.1002/1098-1004(200006)15:6<509::AID-HUMU3>3.0.CO;2-# |s2cid=196604223 }}
• {{Cite journal |vauthors=Fransen M, Wylin T, Brees C, etal |title=Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences. |journal=Mol. Cell. Biol. |volume=21 |issue= 13 |pages= 4413–24 |year= 2001 |pmid= 11390669 |doi= 10.1128/MCB.21.13.4413-4424.2001 | pmc=87101 }}
• {{Cite journal |vauthors=Fransen M, Brees C, Ghys K, etal |title=Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay. |journal=Mol. Cell. Proteomics |volume=1 |issue= 3 |pages= 243–52 |year= 2002 |pmid= 12096124 |doi=10.1074/mcp.M100025-MCP200 |doi-access=free }}
• {{Cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
• {{Cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
• {{Cite book |vauthors=Shimozawa N, Nagase T, Takemoto Y, etal |title=Peroxisomal Disorders and Regulation of Genes |chapter=Genetic Heterogeneity in Japanese Patients with Peroxisome Biogenesis Disorders and Evidence for a Founder Haplotype for the Most Common Mutation in PEX10 Gene |volume=544 |pages= 71 |pmid= 14713216 |doi= 10.1007/978-1-4419-9072-3_10|series=Advances in Experimental Medicine and Biology |date=2003 |isbn=978-1-4613-4782-8 }}
• {{Cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
• {{Cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
• {{Cite journal |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |doi-access= free }}

{{Refend}}

• [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=pbd GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum]
• [https://www.ncbi.nlm.nih.gov/omim/170993,202370,214100,266510,600279,600414,601498,601758,601789,601791,602136,602859,603164,603360,608666,170993,202370,214100,266510,600279,600414,601498,601758,601789,601791,602136,602859,603164,603360,608666 OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum]

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