PEX5

PEX5 has been shown to interact with PEX12,{{cite journal | vauthors = Chang CC, Warren DS, Sacksteder KA, Gould SJ | title = PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import | journal = The Journal of Cell Biology | volume = 147 | issue = 4 | pages = 761–74 | date = Nov 1999 | pmid = 10562279 | pmc = 2156163 | doi = 10.1083/jcb.147.4.761 }}{{cite journal | vauthors = Okumoto K, Abe I, Fujiki Y | title = Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p | journal = The Journal of Biological Chemistry | volume = 275 | issue = 33 | pages = 25700–10 | date = Aug 2000 | pmid = 10837480 | doi = 10.1074/jbc.M003303200 | doi-access = free }} PEX13{{cite journal | vauthors = Gould SJ, Kalish JE, Morrell JC, Bjorkman J, Urquhart AJ, Crane DI | title = Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor | journal = The Journal of Cell Biology | volume = 135 | issue = 1 | pages = 85–95 | date = Oct 1996 | pmid = 8858165 | pmc = 2121023 | doi = 10.1083/jcb.135.1.85 }}{{cite journal | vauthors = Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y | title = Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import | journal = Molecular and Cellular Biology | volume = 22 | issue = 6 | pages = 1639–55 | date = Mar 2002 | pmid = 11865044 | pmc = 135613 | doi = 10.1128/MCB.22.6.1639-1655.2002 }} and PEX14.{{cite journal | vauthors = Shimizu N, Itoh R, Hirono Y, Otera H, Ghaedi K, Tateishi K, Tamura S, Okumoto K, Harano T, Mukai S, Fujiki Y | title = The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis | journal = The Journal of Biological Chemistry | volume = 274 | issue = 18 | pages = 12593–604 | date = Apr 1999 | pmid = 10212238 | doi = 10.1074/jbc.274.18.12593 | doi-access = free }}

{{Reflist}}

{{Refbegin | 2}}

• {{cite journal | vauthors = Fransen M, Brees C, Baumgart E, Vanhooren JC, Baes M, Mannaerts GP, Van Veldhoven PP | title = Identification and characterization of the putative human peroxisomal C-terminal targeting signal import receptor | journal = The Journal of Biological Chemistry | volume = 270 | issue = 13 | pages = 7731–6 | date = Mar 1995 | pmid = 7706321 | doi = 10.1074/jbc.270.13.7731 | doi-access = free }}
• {{cite journal | vauthors = Dodt G, Braverman N, Wong C, Moser A, Moser HW, Watkins P, Valle D, Gould SJ | title = Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders | journal = Nature Genetics | volume = 9 | issue = 2 | pages = 115–25 | date = Feb 1995 | pmid = 7719337 | doi = 10.1038/ng0295-115 | s2cid = 8469214 }}
• {{cite journal | vauthors = Wiemer EA, Nuttley WM, Bertolaet BL, Li X, Francke U, Wheelock MJ, Anné UK, Johnson KR, Subramani S | title = Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders | journal = The Journal of Cell Biology | volume = 130 | issue = 1 | pages = 51–65 | date = Jul 1995 | pmid = 7790377 | pmc = 2120514 | doi = 10.1083/jcb.130.1.51 }}
• {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors = Marynen P, Fransen M, Raeymaekers P, Mannaerts GP, Van Veldhoven PP | title = The gene for the peroxisomal targeting signal import receptor (PXR1) is located on human chromosome 12p13, flanked by TPI1 and D12S1089 | journal = Genomics | volume = 30 | issue = 2 | pages = 366–8 | date = Nov 1995 | pmid = 8586442 | doi = 10.1006/geno.1995.0032 }}
• {{cite journal | vauthors = Gould SJ, Kalish JE, Morrell JC, Bjorkman J, Urquhart AJ, Crane DI | title = Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor | journal = The Journal of Cell Biology | volume = 135 | issue = 1 | pages = 85–95 | date = Oct 1996 | pmid = 8858165 | pmc = 2121023 | doi = 10.1083/jcb.135.1.85 }}
• {{cite journal | vauthors = Dodt G, Gould SJ | title = Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor: evidence that PTS1 protein import is mediated by a cycling receptor | journal = The Journal of Cell Biology | volume = 135 | issue = 6 Pt 2 | pages = 1763–74 | date = Dec 1996 | pmid = 8991089 | pmc = 2133940 | doi = 10.1083/jcb.135.6.1763 }}
• {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
• {{cite journal | vauthors = Reuber BE, Germain-Lee E, Collins CS, Morrell JC, Ameritunga R, Moser HW, Valle D, Gould SJ | title = Mutations in PEX1 are the most common cause of peroxisome biogenesis disorders | journal = Nature Genetics | volume = 17 | issue = 4 | pages = 445–8 | date = Dec 1997 | pmid = 9398847 | doi = 10.1038/ng1297-445 | s2cid = 34034756 }}
• {{cite journal | vauthors = Otera H, Okumoto K, Tateishi K, Ikoma Y, Matsuda E, Nishimura M, Tsukamoto T, Osumi T, Ohashi K, Higuchi O, Fujiki Y | title = Peroxisome targeting signal type 1 (PTS1) receptor is involved in import of both PTS1 and PTS2: studies with PEX5-defective CHO cell mutants | journal = Molecular and Cellular Biology | volume = 18 | issue = 1 | pages = 388–99 | date = Jan 1998 | pmid = 9418886 | pmc = 121509 | doi = 10.1128/mcb.18.1.388}}
• {{cite journal | vauthors = Fransen M, Terlecky SR, Subramani S | title = Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 14 | pages = 8087–92 | date = Jul 1998 | pmid = 9653144 | pmc = 20933 | doi = 10.1073/pnas.95.14.8087 | bibcode = 1998PNAS...95.8087F | doi-access = free }}
• {{cite journal | vauthors = Amery L, Brees C, Baes M, Setoyama C, Miura R, Mannaerts GP, Van Veldhoven PP | title = C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal | journal = The Biochemical Journal | volume = 336 | issue = Pt 2 | pages = 367–71 | date = Dec 1998 | pmid = 9820813 | pmc = 1219880 | doi = 10.1042/bj3360367}}
• {{cite journal | vauthors = Shimizu N, Itoh R, Hirono Y, Otera H, Ghaedi K, Tateishi K, Tamura S, Okumoto K, Harano T, Mukai S, Fujiki Y | title = The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis | journal = The Journal of Biological Chemistry | volume = 274 | issue = 18 | pages = 12593–604 | date = Apr 1999 | pmid = 10212238 | doi = 10.1074/jbc.274.18.12593 | doi-access = free }}
• {{cite journal | vauthors = Shimozawa N, Zhang Z, Suzuki Y, Imamura A, Tsukamoto T, Osumi T, Fujiki Y, Orii T, Barth PG, Wanders RJ, Kondo N | title = Functional heterogeneity of C-terminal peroxisome targeting signal 1 in PEX5-defective patients | journal = Biochemical and Biophysical Research Communications | volume = 262 | issue = 2 | pages = 504–8 | date = Aug 1999 | pmid = 10462504 | doi = 10.1006/bbrc.1999.1232 }}
• {{cite journal | vauthors = Chang CC, Warren DS, Sacksteder KA, Gould SJ | title = PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import | journal = The Journal of Cell Biology | volume = 147 | issue = 4 | pages = 761–74 | date = Nov 1999 | pmid = 10562279 | pmc = 2156163 | doi = 10.1083/jcb.147.4.761 }}
• {{cite journal | vauthors = Watters D, Kedar P, Spring K, Bjorkman J, Chen P, Gatei M, Birrell G, Garrone B, Srinivasa P, Crane DI, Lavin MF | title = Localization of a portion of extranuclear ATM to peroxisomes | journal = The Journal of Biological Chemistry | volume = 274 | issue = 48 | pages = 34277–82 | date = Nov 1999 | pmid = 10567403 | doi = 10.1074/jbc.274.48.34277 | hdl = 10072/122346 | s2cid = 14334129 | url = http://espace.library.uq.edu.au/view/UQ:143352/UQ143352_OA.pdf | doi-access = free }}
• {{cite journal | vauthors = Okumoto K, Abe I, Fujiki Y | title = Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p | journal = The Journal of Biological Chemistry | volume = 275 | issue = 33 | pages = 25700–10 | date = Aug 2000 | pmid = 10837480 | doi = 10.1074/jbc.M003303200 | doi-access = free }}
• {{cite journal | vauthors = Gatto GJ, Geisbrecht BV, Gould SJ, Berg JM | title = Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5 | journal = Nature Structural Biology | volume = 7 | issue = 12 | pages = 1091–5 | date = Dec 2000 | pmid = 11101887 | doi = 10.1038/81930 | s2cid = 35168630 }}
• {{cite journal | vauthors = Harano T, Nose S, Uezu R, Shimizu N, Fujiki Y | title = Hsp70 regulates the interaction between the peroxisome targeting signal type 1 (PTS1)-receptor Pex5p and PTS1 | journal = The Biochemical Journal | volume = 357 | issue = Pt 1 | pages = 157–65 | date = Jul 2001 | pmid = 11415446 | pmc = 1221938 | doi = 10.1042/0264-6021:3570157 }}
• {{cite journal | vauthors = Saidowsky J, Dodt G, Kirchberg K, Wegner A, Nastainczyk W, Kunau WH, Schliebs W | title = The di-aromatic pentapeptide repeats of the human peroxisome import receptor PEX5 are separate high affinity binding sites for the peroxisomal membrane protein PEX14 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 37 | pages = 34524–9 | date = Sep 2001 | pmid = 11438541 | doi = 10.1074/jbc.M104647200 | doi-access = free }}
• {{cite journal | vauthors = Stanley WA, Filipp FV, Kursula P, Schüller N, Erdmann R, Schliebs W, Sattler M, Wilmanns M | title = Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p | journal = Molecular Cell | volume = 24 | issue = 5 | pages = 653–63 | date = Dec 2006 | pmid = 17157249 | pmc = 5030714 | doi = 10.1016/j.molcel.2006.10.024 }}

{{Refend}}

• [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=pbd GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum]
• [https://www.ncbi.nlm.nih.gov/omim/170993,202370,214100,266510,600279,600414,601498,601758,601789,601791,602136,602859,603164,603360,608666,170993,202370,214100,266510,600279,600414,601498,601758,601789,601791,602136,602859,603164,603360,608666 OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum]

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