PFDN1
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{{Short description|Protein-coding gene in the species Homo sapiens}}
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Prefoldin subunit 1 is a protein that in humans is encoded by the PFDN1 gene.{{cite journal | vauthors = Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ | title = Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin | journal = Cell | volume = 93 | issue = 5 | pages = 863–73 |date=Jul 1998 | pmid = 9630229 | doi =10.1016/S0092-8674(00)81446-4 | s2cid = 16011829 | doi-access = free }}
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled coils.{{cite web | title = Entrez Gene: PFDN1 prefoldin subunit 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5201}}
References
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Further reading
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- {{cite journal | vauthors=Hartl FU, Hayer-Hartl M |title=Molecular chaperones in the cytosol: from nascent chain to folded protein. |journal=Science |volume=295 |issue= 5561 |pages= 1852–8 |year= 2002 |pmid= 11884745 |doi= 10.1126/science.1068408 |bibcode=2002Sci...295.1852H |s2cid=15037639 }}
- {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal | vauthors=Iijima M, Kano Y, Nohno T, Namba M |title=Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines |journal=Acta Med. Okayama |volume=50 |issue= 2 |pages= 73–7 |year= 1996 |pmid= 8744932 }}
- {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
- {{cite journal |vauthors=Horrigan SK, Bartoloni L, Speer MC, etal |title=A radiation hybrid breakpoint map of the acute myeloid leukemia (AML) and limb-girdle muscular dystrophy 1A (LGMD1A) regions of chromosome 5q31 localizing 122 expressed sequences |journal=Genomics |volume=57 |issue= 1 |pages= 24–35 |year= 1999 |pmid= 10191080 |doi= 10.1006/geno.1999.5765 }}
- {{cite journal | vauthors=Hansen WJ, Cowan NJ, Welch WJ |title=Prefoldin–Nascent Chain Complexes in the Folding of Cytoskeletal Proteins |journal=J. Cell Biol. |volume=145 |issue= 2 |pages= 265–77 |year= 1999 |pmid= 10209023 |doi=10.1083/jcb.145.2.265 | pmc=2133115 }}
- {{cite journal | vauthors=Cowan NJ, Lewis SA |title=A chaperone with a hydrophilic surface |journal=Nat. Struct. Biol. |volume=6 |issue= 11 |pages= 990–1 |year= 2002 |pmid= 10542082 |doi= 10.1038/14870 |s2cid=22081346 }}
- {{cite journal |vauthors=Munnia A, Schütz N, Romeike BF, etal |title=Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor |journal=Oncogene |volume=20 |issue= 35 |pages= 4853–63 |year= 2001 |pmid= 11521196 |doi= 10.1038/sj.onc.1204650 |s2cid=1636204 |doi-access= }}
- {{cite journal |vauthors=Rommelaere H, De Neve M, Neirynck K, etal |title=Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41023–8 |year= 2001 |pmid= 11535601 |doi= 10.1074/jbc.M106591200 |doi-access= free }}
- {{cite journal |vauthors=Martín-Benito J, Boskovic J, Gómez-Puertas P, etal |title=Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT |journal=EMBO J. |volume=21 |issue= 23 |pages= 6377–86 |year= 2003 |pmid= 12456645 |doi=10.1093/emboj/cdf640 | pmc=136944 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Bruneel A, Labas V, Mailloux A, etal |title=Proteomic study of human umbilical vein endothelial cells in culture |journal=Proteomics |volume=3 |issue= 5 |pages= 714–23 |year= 2004 |pmid= 12748950 |doi= 10.1002/pmic.200300409 |s2cid=19895166 }}
- {{cite journal |vauthors=Gstaiger M, Luke B, Hess D, etal |title=Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI |journal=Science |volume=302 |issue= 5648 |pages= 1208–12 |year= 2003 |pmid= 14615539 |doi= 10.1126/science.1088401 |bibcode=2003Sci...302.1208G |s2cid=26836888 }}
- {{cite journal |vauthors=Simons CT, Staes A, Rommelaere H, etal |title=Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4196–203 |year= 2004 |pmid= 14634002 |doi= 10.1074/jbc.M306053200 |doi-access= free }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |hdl= 11858/00-001M-0000-0010-8592-0 |s2cid=8235923 |hdl-access= free }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
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