PFDN4
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Prefoldin subunit 4 is a protein that in humans is encoded by the PFDN4 gene.{{cite journal | vauthors = Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ | title = Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin | journal = Cell | volume = 93 | issue = 5 | pages = 863–73 | date = May 1998 | pmid = 9630229 | doi = 10.1016/s0092-8674(00)81446-4 | s2cid = 16011829 | doi-access = free }}{{cite journal | vauthors = Iijima M, Kano Y, Nohno T, Namba M | title = Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines | journal = Acta Medica Okayama | volume = 50 | issue = 2 | pages = 73–7 | date = Apr 1996 | pmid = 8744932 }}{{cite journal | vauthors = Coraboeuf E, Deroubaix E, Hoerter J | title = Control of ionic permeabilities in normal and ischemic heart | journal = Circulation Research | volume = 38 | issue = 5 Suppl 1 | pages = I92–8 | date = May 1976 | pmid = 5203 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5203 }}
Function
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.
References
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Further reading
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- {{cite journal | vauthors = Hartl FU, Hayer-Hartl M | title = Molecular chaperones in the cytosol: from nascent chain to folded protein | journal = Science | volume = 295 | issue = 5561 | pages = 1852–8 | date = Mar 2002 | pmid = 11884745 | doi = 10.1126/science.1068408 | bibcode = 2002Sci...295.1852H | s2cid = 15037639 }}
- {{cite journal | vauthors = Hansen WJ, Cowan NJ, Welch WJ | title = Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins | journal = The Journal of Cell Biology | volume = 145 | issue = 2 | pages = 265–77 | date = Apr 1999 | pmid = 10209023 | pmc = 2133115 | doi = 10.1083/jcb.145.2.265 }}
- {{cite journal | vauthors = Cowan NJ, Lewis SA | title = A chaperone with a hydrophilic surface | journal = Nature Structural Biology | volume = 6 | issue = 11 | pages = 990–1 | date = Nov 1999 | pmid = 10542082 | doi = 10.1038/14870 | s2cid = 22081346 }}
- {{cite journal | vauthors = Collins C, Volik S, Kowbel D, Ginzinger D, Ylstra B, Cloutier T, Hawkins T, Predki P, Martin C, Wernick M, Kuo WL, Alberts A, Gray JW | title = Comprehensive genome sequence analysis of a breast cancer amplicon | journal = Genome Research | volume = 11 | issue = 6 | pages = 1034–42 | date = Jun 2001 | pmid = 11381030 | pmc = 311107 | doi = 10.1101/gr.gr1743r}}
- {{cite journal | vauthors = Martín-Benito J, Boskovic J, Gómez-Puertas P, Carrascosa JL, Simons CT, Lewis SA, Bartolini F, Cowan NJ, Valpuesta JM | title = Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT | journal = The EMBO Journal | volume = 21 | issue = 23 | pages = 6377–86 | date = Dec 2002 | pmid = 12456645 | pmc = 136944 | doi = 10.1093/emboj/cdf640 }}
- {{cite journal | vauthors = Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W | title = Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI | journal = Science | volume = 302 | issue = 5648 | pages = 1208–12 | date = Nov 2003 | pmid = 14615539 | doi = 10.1126/science.1088401 | bibcode = 2003Sci...302.1208G | s2cid = 26836888 }}
- {{cite journal | vauthors = Simons CT, Staes A, Rommelaere H, Ampe C, Lewis SA, Cowan NJ | title = Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding | journal = The Journal of Biological Chemistry | volume = 279 | issue = 6 | pages = 4196–203 | date = Feb 2004 | pmid = 14634002 | doi = 10.1074/jbc.M306053200 | doi-access = free }}
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