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PFDN5

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Prefoldin subunit 5 is a protein that in humans is encoded by the PFDN5 gene.{{cite journal | vauthors = Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ | title = Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin | journal = Cell | volume = 93 | issue = 5 | pages = 863–73 | date = May 1998 | pmid = 9630229 | doi = 10.1016/S0092-8674(00)81446-4 | s2cid = 16011829 | doi-access = free }}{{cite journal | vauthors = Mori K, Maeda Y, Kitaura H, Taira T, Iguchi-Ariga SM, Ariga H | title = MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc | journal = The Journal of Biological Chemistry | volume = 273 | issue = 45 | pages = 29794–800 | date = November 1998 | pmid = 9792694 | doi = 10.1074/jbc.273.45.29794 | doi-access = free }}{{cite web | title = Entrez Gene: PFDN5 prefoldin subunit 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5204}}

This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described.

Interactions

PFDN5 has been shown to interact with Myc.{{cite journal | vauthors = Fujioka Y, Taira T, Maeda Y, Tanaka S, Nishihara H, Iguchi-Ariga SM, Nagashima K, Ariga H | title = MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer | journal = The Journal of Biological Chemistry | volume = 276 | issue = 48 | pages = 45137–44 | date = November 2001 | pmid = 11567024 | doi = 10.1074/jbc.M106127200 | doi-access = free }}

References

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Further reading

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  • {{cite journal | vauthors = Hansen WJ, Cowan NJ, Welch WJ | title = Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins | journal = The Journal of Cell Biology | volume = 145 | issue = 2 | pages = 265–77 | date = April 1999 | pmid = 10209023 | pmc = 2133115 | doi = 10.1083/jcb.145.2.265 }}
  • {{cite journal | vauthors = Cowan NJ, Lewis SA | title = A chaperone with a hydrophilic surface | journal = Nature Structural Biology | volume = 6 | issue = 11 | pages = 990–1 | date = November 1999 | pmid = 10542082 | doi = 10.1038/14870 | s2cid = 22081346 }}
  • {{cite journal | vauthors = Rommelaere H, De Neve M, Neirynck K, Peelaers D, Waterschoot D, Goethals M, Fraeyman N, Vandekerckhove J, Ampe C | title = Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families | journal = The Journal of Biological Chemistry | volume = 276 | issue = 44 | pages = 41023–8 | date = November 2001 | pmid = 11535601 | doi = 10.1074/jbc.M106591200 | doi-access = free }}
  • {{cite journal | vauthors = Fujioka Y, Taira T, Maeda Y, Tanaka S, Nishihara H, Iguchi-Ariga SM, Nagashima K, Ariga H | title = MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer | journal = The Journal of Biological Chemistry | volume = 276 | issue = 48 | pages = 45137–44 | date = November 2001 | pmid = 11567024 | doi = 10.1074/jbc.M106127200 | doi-access = free }}
  • {{cite journal | vauthors = Watanabe K, Ozaki T, Nakagawa T, Miyazaki K, Takahashi M, Hosoda M, Hayashi S, Todo S, Nakagawara A | title = Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function | journal = The Journal of Biological Chemistry | volume = 277 | issue = 17 | pages = 15113–23 | date = April 2002 | pmid = 11844794 | doi = 10.1074/jbc.M111281200 | doi-access = free }}
  • {{cite journal | vauthors = Simons CT, Staes A, Rommelaere H, Ampe C, Lewis SA, Cowan NJ | title = Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding | journal = The Journal of Biological Chemistry | volume = 279 | issue = 6 | pages = 4196–203 | date = February 2004 | pmid = 14634002 | doi = 10.1074/jbc.M306053200 | doi-access = free }}
  • {{cite journal | vauthors = Bruneel A, Labas V, Mailloux A, Sharma S, Royer N, Vinh J, Pernet P, Vaubourdolle M, Baudin B | title = Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis | journal = Proteomics | volume = 5 | issue = 15 | pages = 3876–84 | date = October 2005 | pmid = 16130169 | doi = 10.1002/pmic.200401239 | s2cid = 26007149 }}
  • {{cite journal | vauthors = Hagio Y, Kimura Y, Taira T, Fujioka Y, Iguchi-Ariga SM, Ariga H | title = Distinct localizations and repression activities of MM-1 isoforms toward c-Myc | journal = Journal of Cellular Biochemistry | volume = 97 | issue = 1 | pages = 145–55 | date = January 2006 | pmid = 16173081 | doi = 10.1002/jcb.20619 | s2cid = 6803370 }}

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