PGDS
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
PGDS protein is a protein that in humans is encoded by the HPGDS gene.{{cite journal | vauthors = Kanaoka Y, Ago H, Inagaki E, Nanayama T, Miyano M, Kikuno R, Fujii Y, Eguchi N, Toh H, Urade Y, Hayaishi O | title = Cloning and crystal structure of hematopoietic prostaglandin D synthase | journal = Cell | volume = 90 | issue = 6 | pages = 1085–95 |date=Oct 1997 | pmid = 9323136 | doi =10.1016/S0092-8674(00)80374-8 | s2cid = 933875 | doi-access = free }}{{cite journal | vauthors = Mahmud I, Ueda N, Yamaguchi H, Yamashita R, Yamamoto S, Kanaoka Y, Urade Y, Hayaishi O | title = Prostaglandin D synthase in human megakaryoblastic cells | journal = J Biol Chem | volume = 272 | issue = 45 | pages = 28263–6 |date=Dec 1997 | pmid = 9353279 | doi =10.1074/jbc.272.45.28263 | doi-access = free }}{{cite journal | vauthors = Jowsey IR, Thomson AM, Flanagan JU, Murdock PR, Moore GB, Meyer DJ, Murphy GJ, Smith SA, Hayes JD | title = Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases | journal = Biochem J | volume = 359 | issue = Pt 3 | pages = 507–16 |date=Oct 2001 | pmid = 11672424 | pmc = 1222171 | doi =10.1042/0264-6021:3590507 }}{{cite web | title = Entrez Gene: PGDS prostaglandin D2 synthase, hematopoietic| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27306}}
Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes.
See also
References
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Further reading
{{refbegin | 2}}
- {{cite journal | vauthors=Kanaoka Y, Urade Y |title=Hematopoietic prostaglandin D synthase. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=69 |issue= 2–3 |pages= 163–7 |year= 2004 |pmid= 12895599 |doi=10.1016/S0952-3278(03)00077-2 }}
- {{cite journal |vauthors=Suzuki T, Watanabe K, Kanaoka Y, etal |title=Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester. |journal=Biochem. Biophys. Res. Commun. |volume=241 |issue= 2 |pages= 288–93 |year= 1998 |pmid= 9425264 |doi= 10.1006/bbrc.1997.7803 }}
- {{cite journal |vauthors=Tokugawa Y, Kunishige I, Kubota Y, etal |title=Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma. |journal=Biol. Reprod. |volume=58 |issue= 2 |pages= 600–7 |year= 1998 |pmid= 9475419 |doi=10.1095/biolreprod58.2.600 |doi-access=free }}
- {{cite journal |vauthors=Pinzar E, Kanaoka Y, Inui T, etal |title=Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4903–7 |year= 2000 |pmid= 10781097 |doi= 10.1073/pnas.090093997 | pmc=18330 |bibcode=2000PNAS...97.4903P |doi-access=free }}
- {{cite journal |vauthors=Kanaoka Y, Fujimori K, Kikuno R, etal |title=Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase. |journal=Eur. J. Biochem. |volume=267 |issue= 11 |pages= 3315–22 |year= 2000 |pmid= 10824118 |doi=10.1046/j.1432-1327.2000.01362.x |doi-access=free }}
- {{cite journal | vauthors=Fujimori K, Kanaoka Y, Sakaguchi Y, Urade Y |title=Transcriptional activation of the human hematopoietic prostaglandin D synthase gene in megakaryoblastic cells. Roles of the oct-1 element in the 5'-flanking region and the AP-2 element in the untranslated exon 1. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 40511–6 |year= 2001 |pmid= 10998423 |doi= 10.1074/jbc.M007688200 |doi-access= free }}
- {{cite journal | vauthors=Sui D, Wilson JE |title=Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase. |journal=Arch. Biochem. Biophys. |volume=382 |issue= 2 |pages= 262–74 |year= 2000 |pmid= 11068878 |doi= 10.1006/abbi.2000.2019 }}
- {{cite journal |vauthors=Noguchi E, Shibasaki M, Kamioka M, etal |title=New polymorphisms of haematopoietic prostaglandin D synthase and human prostanoid DP receptor genes. |journal=Clin. Exp. Allergy |volume=32 |issue= 1 |pages= 93–6 |year= 2002 |pmid= 12002745 |doi=10.1046/j.0022-0477.2001.01261.x |s2cid=24779233 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Inoue T, Irikura D, Okazaki N, etal |title=Mechanism of metal activation of human hematopoietic prostaglandin D synthase. |journal=Nat. Struct. Biol. |volume=10 |issue= 4 |pages= 291–6 |year= 2003 |pmid= 12627223 |doi= 10.1038/nsb907 |s2cid=25214344 }}
- {{cite journal |vauthors=Ando M, Murakami Y, Kojima F, etal |title=Retrovirally introduced prostaglandin D2 synthase suppresses lung injury induced by bleomycin. |journal=Am. J. Respir. Cell Mol. Biol. |volume=28 |issue= 5 |pages= 582–91 |year= 2003 |pmid= 12707014 |doi= 10.1165/rcmb.2002-0162OC }}
- {{cite journal |vauthors=Inoue T, Okano Y, Kado Y, etal |title=First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase. |journal=J. Biochem. |volume=135 |issue= 3 |pages= 279–83 |year= 2005 |pmid= 15113825 |doi=10.1093/jb/mvh033 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
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