PHB2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{cs1 config|name-list-style=vanc}}
{{Infobox_gene}}
Prohibitin-2 is a protein that in humans is encoded by the PHB2 gene.{{cite journal |vauthors=Coates PJ, Nenutil R, McGregor A, Picksley SM, Crouch DH, Hall PA, Wright EG | title = Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence | journal = Exp Cell Res | volume = 265 | issue = 2 | pages = 262–73 |date=Apr 2001 | pmid = 11302691 | doi = 10.1006/excr.2001.5166 }}{{cite journal |vauthors=Coates PJ, Jamieson DJ, Smart K, Prescott AR, Hall PA | title = The prohibitin family of mitochondrial proteins regulate replicative lifespan | journal = Curr Biol | volume = 7 | issue = 8 | pages = 607–10 |date=Oct 1997 | pmid = 9259555 | doi =10.1016/S0960-9822(06)00261-2 | s2cid = 7153605 | doi-access = free | bibcode = 1997CBio....7..607C }}{{cite web | title = Entrez Gene: PHB2 prohibitin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11331}}
Interactions
PHB2 has been shown to interact with PTMA.{{cite journal |doi=10.1016/S0960-0760(03)00207-3 |last=Martini |first=Paolo G V |author2=Katzenellenbogen Benita S |date=Jun 2003 |title=Modulation of estrogen receptor activity by selective coregulators |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue=2–5 |pages=117–22 | issn = 0960-0760| pmid = 12943695 |s2cid=32374864 }}
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Martini PG, Katzenellenbogen BS |title=Modulation of estrogen receptor activity by selective coregulators |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue= 2–5 |pages= 117–22 |year= 2003 |pmid= 12943695 |doi=10.1016/S0960-0760(03)00207-3 |s2cid=32374864 }}
- {{cite journal |vauthors=Ansari-Lari MA, Muzny DM, Lu J, etal |title=A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13 |journal=Genome Res. |volume=6 |issue= 4 |pages= 314–26 |year= 1996 |pmid= 8723724 |doi=10.1101/gr.6.4.314 |doi-access=free }}
- {{cite journal |vauthors=Ansari-Lari MA, Shen Y, Muzny DM, etal |title=Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination |journal=Genome Res. |volume=7 |issue= 3 |pages= 268–80 |year= 1997 |pmid= 9074930 |doi=10.1101/gr.7.3.268 |doi-access=free }}
- {{cite journal |vauthors=Montano MM, Ekena K, Delage-Mourroux R, etal |title=An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 12 |pages= 6947–52 |year= 1999 |pmid= 10359819 |doi=10.1073/pnas.96.12.6947 | pmc=22022 |bibcode=1999PNAS...96.6947M |doi-access=free }}
- {{cite journal |vauthors=Hu RM, Han ZG, Song HD, etal |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 | pmc=16901 |bibcode=2000PNAS...97.9543H |doi-access=free }}
- {{cite journal |vauthors=Martini PG, Delage-Mourroux R, Kraichely DM, Katzenellenbogen BS |title=Prothymosin Alpha Selectively Enhances Estrogen Receptor Transcriptional Activity by Interacting with a Repressor of Estrogen Receptor Activity |journal=Mol. Cell. Biol. |volume=20 |issue= 17 |pages= 6224–32 |year= 2000 |pmid= 10938099 |doi=10.1128/MCB.20.17.6224-6232.2000 | pmc=86097 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Bouwmeester T, Bauch A, Ruffner H, etal |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 |s2cid=11683986 }}
- {{cite journal |vauthors=Kurtev V, Margueron R, Kroboth K, etal |title=Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24834–43 |year= 2004 |pmid= 15140878 |doi= 10.1074/jbc.M312300200 |doi-access= free }}
- {{cite journal |vauthors=Lehner B, Sanderson CM |title=A Protein Interaction Framework for Human mRNA Degradation |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |s2cid=7200157 }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
- {{cite journal |vauthors=Scherer SE, Muzny DM, Buhay CJ, etal |title=The finished DNA sequence of human chromosome 12 |journal=Nature |volume=440 |issue= 7082 |pages= 346–51 |year= 2006 |pmid= 16541075 |doi= 10.1038/nature04569 |bibcode=2006Natur.440..346S |doi-access=free }}
- {{cite journal |vauthors=Kasashima K, Ohta E, Kagawa Y, Endo H |title=Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2 |journal=J. Biol. Chem. |volume=281 |issue= 47 |pages= 36401–10 |year= 2007 |pmid= 17008324 |doi= 10.1074/jbc.M605260200 |doi-access= free }}
- {{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
- {{cite journal |vauthors=Takata H, Matsunaga S, Morimoto A, etal |title=PHB2 protects sister-chromatid cohesion in mitosis |journal=Curr. Biol. |volume=17 |issue= 15 |pages= 1356–61 |year= 2007 |pmid= 17656096 |doi= 10.1016/j.cub.2007.07.009 |s2cid=18987683 |doi-access=free |bibcode=2007CBio...17.1356T }}
{{refend}}
{{protein-stub}}