PHLPP (gene)

{{Short description|Protein-coding gene in the species Homo sapiens}}

PH domain and leucine rich repeat protein phosphatase, also known as PHLPP, is an enzyme which in humans is encoded by the PHLPP gene.{{cite web | title = Entrez Gene: PHLPP PH domain and leucine rich repeat protein phosphatase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23239| accessdate = }}

References

{{cite journal |vauthors=Nakajima D, Okazaki N, Yamakawa H, etal |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |doi-access=free }}
{{cite journal |vauthors=Nagase T, Ishikawa K, Miyajima N, etal |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=10.1093/dnares/5.1.31 |doi-access=free }}
{{cite journal | vauthors=Shimizu K, Okada M, Takano A, Nagai K |title=SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus. |journal=FEBS Lett. |volume=458 |issue= 3 |pages= 363–9 |year= 2000 |pmid= 10570941 |doi=10.1016/S0014-5793(99)01190-4 |s2cid=38044717 |doi-access=free }}
{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
{{cite journal | vauthors=Gao T, Furnari F, Newton AC |title=PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. |journal=Mol. Cell |volume=18 |issue= 1 |pages= 13–24 |year= 2005 |pmid= 15808505 |doi= 10.1016/j.molcel.2005.03.008 |doi-access= free }}
{{cite journal |vauthors=Zhang Y, Wolf-Yadlin A, Ross PL, etal |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. |journal=Mol. Cell. Proteomics |volume=4 |issue= 9 |pages= 1240–50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200 |doi-access= free }}
{{cite journal |vauthors=Nusbaum C, Zody MC, Borowsky ML, etal |title=DNA sequence and analysis of human chromosome 18. |journal=Nature |volume=437 |issue= 7058 |pages= 551–5 |year= 2005 |pmid= 16177791 |doi= 10.1038/nature03983 |doi-access= free |bibcode=2005Natur.437..551N }}
{{cite journal | vauthors=Brognard J, Sierecki E, Gao T, Newton AC |title=PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. |journal=Mol. Cell |volume=25 |issue= 6 |pages= 917–31 |year= 2007 |pmid= 17386267 |doi= 10.1016/j.molcel.2007.02.017 |doi-access= free }}

PHLPP (gene)

See also

References

Further reading