PI4KA

This gene encodes a 1-phosphatidylinositol 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. Two transcript variants encoding different isoforms have been described for this gene.{{cite web | title = Entrez Gene: PIK4CA phosphatidylinositol 4-kinase, catalytic, alpha polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5297}}

The alpha isoform of PI4KIII plays a role in replication of hepatitis C virus (HCV).{{cite journal |vauthors=Reiss S, Rebhan I, Backes P, Romero-Brey I, Erfle H, Matula P, Kaderali L, Poenisch M, Blankenburg H, Hiet MS, Longerich T, Diehl S, Ramirez F, Balla T, Rohr K, Kaul A, Bühler S, Pepperkok R, Lengauer T, Albrecht M, Eils R, Schirmacher P, Lohmann V, Bartenschlager R | title = Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment | journal = Cell Host Microbe | volume = 9 | issue = 1 | pages = 32–45 |date=January 2011 | pmid = 21238945 | pmc = 3433060 | doi = 10.1016/j.chom.2010.12.002 }} Furthermore, the PI4KA lipid kinase affects HCV replication by altering phosphorylation of the HCV NS5A protein.{{cite journal |vauthors=Reiss S, Harak C, Romero-Brey I, Radujkovic D, Klein R, Ruggieri A, Rebhan I, Bartenschlager R, Lohmann V | title = The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A | journal = PLOS Pathog. | volume = 9 | issue = 5 | pages = e1003359 |date=May 2013 | pmid = 23675303 | pmc = 3649985 | doi = 10.1371/journal.ppat.1003359 | doi-access = free }}

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• {{cite journal |vauthors=Israels SJ, McMillan-Ward EM |title=CD63 modulates spreading and tyrosine phosphorylation of platelets on immobilized fibrinogen |journal=Thromb. Haemost. |volume=93 |issue= 2 |pages= 311–8 |year= 2005 |pmid= 15711748 |doi= 10.1160/TH04-08-0503 |s2cid=36437042 }}
• {{cite journal |vauthors=Waugh MG, Minogue S, Chotai D, etal |title=Lipid and peptide control of phosphatidylinositol 4-kinase IIalpha activity on Golgi-endosomal Rafts |journal=J. Biol. Chem. |volume=281 |issue= 7 |pages= 3757–63 |year= 2006 |pmid= 16249177 |doi= 10.1074/jbc.M506527200 |doi-access= free }}
• {{cite journal |vauthors=Israels SJ, McMillan-Ward EM |title=CD63 modulates spreading and tyrosine phosphorylation of platelets on immobilized fibrinogen |journal=Thromb. Haemost. |volume=93 |issue= 2 |pages= 311–8 |year= 2005 |pmid= 15711748 |doi= 10.1160/TH04-08-0503 |s2cid=36437042 }}
• {{cite journal |vauthors=Reiss S, etal |title=Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment |journal=Cell Host Microbe |volume=9 |issue= 1 |pages= 32–45 |year= 2011 |pmid= 21238945 |doi= 10.1016/j.chom.2010.12.002 |pmc=3433060}}
• {{cite journal |vauthors=Reiss S, etal |title=The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A |journal=PLOS Pathog. |volume=9 |issue= 5 |pages= e1003359 |year= 2013 |pmid= 23675303 |doi= 10.1371/journal.ppat.1003359 |pmc=3649985 |doi-access=free }}

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{{Kinases}}

{{Enzymes}}

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Category:EC 2.7.1