PIAS1

This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.

PIAS1 has been shown to interact with:

• DNMT3A,{{cite journal | vauthors = Ling Y, Sankpal UT, Robertson AK, McNally JG, Karpova T, Robertson KD | title = Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription | journal = Nucleic Acids Res. | year = 2004 | volume = 32 | issue = 2 | pages = 598–610 | pmid = 14752048 | pmc = 373322 | doi = 10.1093/nar/gkh195 }}
• P53,{{cite journal | vauthors = Gallagher WM, Argentini M, Sierra V, Bracco L, Debussche L, Conseiller E | title = MBP1: a novel mutant p53-specific protein partner with oncogenic properties | journal = Oncogene | volume = 18 | issue = 24 | pages = 3608–16 | date = June 1999 | pmid = 10380882 | doi = 10.1038/sj.onc.1202937 | doi-access = free }}
• STAT1,{{cite journal | vauthors = Liao J, Fu Y, Shuai K | title = Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 10 | pages = 5267–72 | date = May 2000 | pmid = 10805787 | pmc = 25817 | doi = 10.1073/pnas.97.10.5267| bibcode = 2000PNAS...97.5267L | doi-access = free }}
• Small ubiquitin-related modifier 1,{{cite journal | vauthors = Kahyo T, Nishida T, Yasuda H | title = Involvement of PIAS1 in the sumoylation of tumor suppressor p53 | journal = Mol. Cell | volume = 8 | issue = 3 | pages = 713–8 | date = September 2001 | pmid = 11583632 | doi = 10.1016/s1097-2765(01)00349-5| doi-access = free }}{{cite journal | vauthors = Lee BH, Yoshimatsu K, Maeda A, Ochiai K, Morimatsu M, Araki K, Ogino M, Morikawa S, Arikawa J | title = Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules | journal = Virus Res. | volume = 98 | issue = 1 | pages = 83–91 | date = December 2003 | pmid = 14609633 | doi = 10.1016/j.virusres.2003.09.001}}
• Sp3 transcription factor,{{cite journal | vauthors = Sapetschnig A, Rischitor G, Braun H, Doll A, Schergaut M, Melchior F, Suske G | title = Transcription factor Sp3 is silenced through SUMO modification by PIAS1 | journal = EMBO J. | volume = 21 | issue = 19 | pages = 5206–15 | date = October 2002 | pmid = 12356736 | pmc = 129032 | doi = 10.1093/emboj/cdf510}} and
• UBE2I.

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• {{cite journal | vauthors = Tan J, Hall SH, Hamil KG, Grossman G, Petrusz P, Liao J, Shuai K, French FS | title = Protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1) is a nuclear receptor coregulator expressed in human testis | journal = Mol. Endocrinol. | volume = 14 | issue = 1 | pages = 14–26 | year = 2000 | pmid = 10628744 | doi = 10.1210/mend.14.1.0408 | doi-access = free }}
• {{cite journal | vauthors = Liao J, Fu Y, Shuai K | title = Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 10 | pages = 5267–5272 | year = 2000 | pmid = 10805787 | pmc = 25817 | doi = 10.1073/pnas.97.10.5267 | bibcode = 2000PNAS...97.5267L | doi-access = free }}
• {{cite journal | vauthors = Kotaja N, Aittomäki S, Silvennoinen O, Palvimo JJ, Jänne OA | title = ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation | journal = Mol. Endocrinol. | volume = 14 | issue = 12 | pages = 1986–2000 | year = 2001 | pmid = 11117529 | doi = 10.1210/mend.14.12.0569 | doi-access = free }}
• {{cite journal | vauthors = Gross M, Liu B, Tan J, French FS, Carey M, Shuai K | title = Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells | journal = Oncogene | volume = 20 | issue = 29 | pages = 3880–3887 | year = 2001 | pmid = 11439351 | doi = 10.1038/sj.onc.1204489 | doi-access = free }}
• {{cite journal | vauthors = Liu B, Shuai K | title = Induction of apoptosis by protein inhibitor of activated Stat1 through c-Jun NH2-terminal kinase activation | journal = J. Biol. Chem. | volume = 276 | issue = 39 | pages = 36624–36631 | year = 2001 | pmid = 11451946 | doi = 10.1074/jbc.M101085200 | doi-access = free }}
• {{cite journal | vauthors = Kahyo T, Nishida T, Yasuda H | title = Involvement of PIAS1 in the sumoylation of tumor suppressor p53 | journal = Mol. Cell | volume = 8 | issue = 3 | pages = 713–718 | year = 2001 | pmid = 11583632 | doi = 10.1016/S1097-2765(01)00349-5 | doi-access = free }}
• {{cite journal | vauthors = Weiskirchen R, Moser M, Weiskirchen S, Erdel M, Dahmen S, Buettner R, Gressner AM | title = LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1 | journal = Biochem. J. | volume = 359 | issue = Pt 3 | pages = 485–96 | year = 2001 | pmid = 11672422 | pmc = 1222169 | doi = 10.1042/0264-6021:3590485 }}
• {{cite journal | vauthors = Megidish T, Xu JH, Xu CW | title = Activation of p53 by protein inhibitor of activated Stat1 (PIAS1) | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 8255–8259 | year = 2002 | pmid = 11788578 | doi = 10.1074/jbc.C200001200 | doi-access = free }}
• {{cite journal | vauthors = Schmidt D, Müller S | title = Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 5 | pages = 2872–2877 | year = 2002 | pmid = 11867732 | pmc = 122440 | doi = 10.1073/pnas.052559499 | bibcode = 2002PNAS...99.2872S | doi-access = free }}
• {{cite journal | vauthors = Tan JA, Hall SH, Hamil KG, Grossman G, Petrusz P, French FS | title = Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators | journal = J. Biol. Chem. | volume = 277 | issue = 19 | pages = 16993–17001 | year = 2002 | pmid = 11877418 | doi = 10.1074/jbc.M109217200 | doi-access = free }}
• {{cite journal | vauthors = Nishida T, Yasuda H | title = PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription | journal = J. Biol. Chem. | volume = 277 | issue = 44 | pages = 41311–41317 | year = 2003 | pmid = 12177000 | doi = 10.1074/jbc.M206741200 | doi-access = free }}
• {{cite journal | vauthors = Rui HL, Fan E, Zhou HM, Xu Z, Zhang Y, Lin SC | title = SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling | journal = J. Biol. Chem. | volume = 277 | issue = 45 | pages = 42981–42986 | year = 2003 | pmid = 12223491 | doi = 10.1074/jbc.M208099200 | doi-access = free }}
• {{cite journal | vauthors = Sapetschnig A, Rischitor G, Braun H, Doll A, Schergaut M, Melchior F, Suske G | title = Transcription factor Sp3 is silenced through SUMO modification by PIAS1 | journal = EMBO J. | volume = 21 | issue = 19 | pages = 5206–5215 | year = 2002 | pmid = 12356736 | pmc = 129032 | doi = 10.1093/emboj/cdf510 }}
• {{cite journal | vauthors = Miyauchi Y, Yogosawa S, Honda R, Nishida T, Yasuda H | title = Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes | journal = J. Biol. Chem. | volume = 277 | issue = 51 | pages = 50131–50136 | year = 2003 | pmid = 12393906 | doi = 10.1074/jbc.M208319200 | doi-access = free }}
• {{cite journal | vauthors = Ungureanu D, Vanhatupa S, Kotaja N, Yang J, Aittomaki S, Jänne OA, Palvimo JJ, Silvennoinen O | title = PIAS proteins promote SUMO-1 conjugation to STAT1 | journal = Blood | volume = 102 | issue = 9 | pages = 3311–3313 | year = 2004 | pmid = 12855578 | doi = 10.1182/blood-2002-12-3816 | doi-access = free }}
• {{cite journal | vauthors = Kadaré G, Toutant M, Formstecher E, Corvol JC, Carnaud M, Boutterin MC, Girault JA | title = PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation | journal = J. Biol. Chem. | volume = 278 | issue = 48 | pages = 47434–47440 | year = 2004 | pmid = 14500712 | doi = 10.1074/jbc.M308562200 | doi-access = free }}
• {{cite journal | vauthors = Tallec LP, Kirsh O, Lecomte MC, Viengchareun S, Zennaro MC, Dejean A, Lombès M | title = Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification | journal = Mol. Endocrinol. | volume = 17 | issue = 12 | pages = 2529–2542 | year = 2004 | pmid = 14500761 | doi = 10.1210/me.2003-0299 | doi-access = free }}
• {{cite journal | vauthors = Coppola D, Parikh V, Boulware D, Blanck G | title = Substantially reduced expression of PIAS1 is associated with colon cancer development | journal = J Cancer Res Clin Oncol | volume = 135 | issue = 9 | pages = 1287–91 | year = 2009 | pmid = 19288270 | doi = 10.1007/s00432-009-0570-z | s2cid = 20383429 }}

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