PIAS4

PIAS4 has been shown to interact with Mothers against decapentaplegic homolog 6,{{cite journal |last=Imoto |first=Seiyu |author2=Sugiyama Kenji |author3=Muromoto Ryuta |author4=Sato Noriko |author5=Yamamoto Tetsuya |author6=Matsuda Tadashi |date=Sep 2003 |title=Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3 |journal=J. Biol. Chem. |volume=278 |issue=36 |pages=34253–8 | issn = 0021-9258| pmid = 12815042 |doi = 10.1074/jbc.M304961200 |doi-access=free |hdl=2115/28123 |hdl-access=free }} Mothers against decapentaplegic homolog 7 and Lymphoid enhancer-binding factor 1.{{cite journal |last=Sachdev |first=S |author2=Bruhn L |author3=Sieber H |author4=Pichler A |author5=Melchior F |author6=Grosschedl R |date=Dec 2001 |title=PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies |journal=Genes Dev. |volume=15 |issue=23 |pages=3088–103 | issn = 0890-9369| pmid = 11731474 |doi=10.1101/gad.944801 |pmc=312834 }} PIAS4 has been shown to be responsible for the SUMOylation of inhibited Werner syndrome helicase (WRN) trapped on DNA in microsatellite unstable cancer cells. {{cite journal | date = July 2024 |vauthors=Rodríguez Pérez F, Natwick D, Schiff L, McSwiggen D, Heckert A, Huey M, Morrison H, Loo M, Miranda RG, Filbin J, Ortega J, Van Buren K, Murnock D, Tao A, Butler R, Cheng K, Tarvestad W, Zhang Z, Gonzalez E, Miller RM, Kelly M, Tang Y, Ho J, Anderson D, Bashore C, Basham S | title = WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis | journal = Nat. Commun. | volume = 15 | issue = 6059 | pmid = 39025847| pmc=11258360 | doi = 10.1038/s41467-024-50178-3| doi-access = free}}

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{{JAK-STAT signaling pathway}}

{{gene-19-stub}}