PIWIL1
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Piwi-like protein 1 is a protein that in humans is encoded by the PIWIL1 gene.{{cite journal | vauthors = Cox DN, Chao A, Baker J, Chang L, Qiao D, Lin H | title = A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal | journal = Genes Dev | volume = 12 | issue = 23 | pages = 3715–27 |date=Jan 1999 | pmid = 9851978 | pmc = 317255 | doi =10.1101/gad.12.23.3715 }}{{cite journal | vauthors = Sasaki T, Shiohama A, Minoshima S, Shimizu N | title = Identification of eight members of the Argonaute family in the human genome small star, filled | journal = Genomics | volume = 82 | issue = 3 | pages = 323–30 |date=Aug 2003 | pmid = 12906857 | doi =10.1016/S0888-7543(03)00129-0 }}{{cite web | title = Entrez Gene: PIWIL1 piwi-like 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9271}}
This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms.
The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells.
References
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Further reading
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- {{cite journal |vauthors=Sharma AK, Nelson MC, Brandt JE, etal |title=Human CD34(+) stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi. |journal=Blood |volume=97 |issue= 2 |pages= 426–34 |year= 2001 |pmid= 11154219 |doi=10.1182/blood.V97.2.426 |doi-access=free }}
- {{cite journal |vauthors=Qiao D, Zeeman AM, Deng W, etal |title=Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas. |journal=Oncogene |volume=21 |issue= 25 |pages= 3988–99 |year= 2002 |pmid= 12037681 |doi= 10.1038/sj.onc.1205505 |doi-access= |s2cid=6078065 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Tahbaz N, Kolb FA, Zhang H, etal |title=Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. |journal=EMBO Rep. |volume=5 |issue= 2 |pages= 189–94 |year= 2004 |pmid= 14749716 |doi= 10.1038/sj.embor.7400070 | pmc=1298981 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Liu X, Sun Y, Guo J, etal |title=Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells. |journal=Int. J. Cancer |volume=118 |issue= 8 |pages= 1922–9 |year= 2006 |pmid= 16287078 |doi= 10.1002/ijc.21575 |s2cid=8616640 |doi-access= }}
- {{cite journal |vauthors=Taubert H, Greither T, Kaushal D, etal |title=Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma. |journal=Oncogene |volume=26 |issue= 7 |pages= 1098–100 |year= 2007 |pmid= 16953229 |doi= 10.1038/sj.onc.1209880 |doi-access= free }}
- {{cite journal |vauthors=Sugimoto K, Kage H, Aki N, etal |title=The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus. |journal=Biochem. Biophys. Res. Commun. |volume=359 |issue= 3 |pages= 497–502 |year= 2007 |pmid= 17544373 |doi= 10.1016/j.bbrc.2007.05.136 }}
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