PKD2L1

TRPP2 is a member of the polycystin protein family. TRPP2 contains multiple transmembrane domains, and cytoplasmic N- and C-termini. TRPP2 may be an integral membrane protein involved in cell-cell/matrix interactions. TRPP2 functions as a calcium-regulated nonselective cation channel. Alternative splice variants have been described but their full length sequences have not been determined.

PKD2L1 has been shown to interact with TNNI3.{{cite journal | vauthors = Li Q, Liu Y, Shen PY, Dai XQ, Wang S, Smillie LB, Sandford R, Chen XZ | title = Troponin I binds polycystin-L and inhibits its calcium-induced channel activation | journal = Biochemistry | volume = 42 | issue = 24 | pages = 7618–25 |date=June 2003 | pmid = 12809519 | doi = 10.1021/bi034210a }}

• TRPP

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• {{cite journal |vauthors=Geng L, Okuhara D, Yu Z, etal |title=Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif. |journal=J. Cell Sci. |volume=119 |issue= Pt 7 |pages= 1383–95 |year= 2006 |pmid= 16537653 |doi= 10.1242/jcs.02818 |doi-access= free }}
• {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
• {{cite journal |vauthors=Li Q, Liu Y, Shen PY, etal |title=Troponin I binds polycystin-L and inhibits its calcium-induced channel activation. |journal=Biochemistry |volume=42 |issue= 24 |pages= 7618–25 |year= 2003 |pmid= 12809519 |doi= 10.1021/bi034210a }}
• {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
• {{cite journal | vauthors=Li Q, Liu Y, Zhao W, Chen XZ |title=The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation. |journal=FEBS Lett. |volume=516 |issue= 1–3 |pages= 270–8 |year= 2002 |pmid= 11959145 |doi= 10.1016/S0014-5793(02)02513-9 |s2cid=1812119 |doi-access=free }}
• {{cite journal |vauthors=Basora N, Nomura H, Berger UV, etal |title=Tissue and cellular localization of a novel polycystic kidney disease-like gene product, polycystin-L |journal=J. Am. Soc. Nephrol. |volume=13 |issue= 2 |pages= 293–301 |year= 2002 |doi=10.1681/ASN.V132293 |pmid= 11805156 |doi-access=free }}
• {{cite journal | vauthors=Stayner C, Zhou J |title=Polycystin channels and kidney disease |journal=Trends Pharmacol. Sci. |volume=22 |issue= 11 |pages= 543–6 |year= 2001 |pmid= 11698076 |doi=10.1016/S0165-6147(00)01832-0 }}
• {{cite journal | vauthors=Guo L, Chen M, Basora N, Zhou J |title=The human polycystic kidney disease 2-like (PKDL) gene: exon/intron structure and evidence for a novel splicing mechanism |journal=Mamm. Genome |volume=11 |issue= 1 |pages= 46–50 |year= 2000 |pmid= 10602992 |doi=10.1007/s003350010009 |s2cid=27177354 }}
• {{cite journal |vauthors=Veldhuisen B, Spruit L, Dauwerse HG, etal |title=Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2) |journal=Eur. J. Hum. Genet. |volume=7 |issue= 8 |pages= 860–72 |year= 2000 |pmid= 10602361 |doi= 10.1038/sj.ejhg.5200383 |doi-access= free }}
• {{cite journal |vauthors=Chen XZ, Vassilev PM, Basora N, etal |title=Polycystin-L is a calcium-regulated cation channel permeable to calcium ions |journal=Nature |volume=401 |issue= 6751 |pages= 383–6 |year= 1999 |pmid= 10517637 |doi= 10.1038/43907 |s2cid=4412921 }}
• {{cite journal |vauthors=Tsiokas L, Arnould T, Zhu C, etal |title=Specific association of the gene product of PKD2 with the TRPC1 channel |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 7 |pages= 3934–9 |year= 1999 |pmid= 10097141 |doi=10.1073/pnas.96.7.3934 | pmc=22398 |bibcode=1999PNAS...96.3934T |doi-access=free }}
• {{cite journal |vauthors=Wu G, Hayashi T, Park JH, etal |title=Identification of PKD2L, a human PKD2-related gene: tissue-specific expression and mapping to chromosome 10q25 |journal=Genomics |volume=54 |issue= 3 |pages= 564–8 |year= 1999 |pmid= 9878261 |doi= 10.1006/geno.1998.5618 |doi-access= free }}
• {{cite journal |vauthors=Nomura H, Turco AE, Pei Y, etal |title=Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25967–73 |year= 1998 |pmid= 9748274 |doi=10.1074/jbc.273.40.25967 |doi-access=free }}

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