PKIB
{{Short description|Protein-coding gene in the species Homo sapiens}}
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cAMP-dependent protein kinase inhibitor beta is a protein that in humans is encoded by the PKIB gene.{{cite journal | vauthors = Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S | title = Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA | journal = Biochem J | volume = 349 | issue = Pt 2 | pages = 403–7 |date=Jan 2001 | pmid = 10880337 | pmc = 1221161 | doi =10.1042/0264-6021:3490403 }}{{cite web | title = Entrez Gene: PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5570}}
The protein encoded by this gene is a member of the cAMP-dependent protein kinase inhibitor family. Studies of a similar protein in rat suggest that this protein may interact with the catalytic subunit of cAMP-dependent protein kinase and act as a competitive inhibitor. At least three alternatively spliced transcript variants encoding the same protein have been reported.
References
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Further reading
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- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |doi-access= free }}
- {{cite journal |vauthors=Giangrande PH, Hallstrom TC, Tunyaplin C, etal |title=Identification of E-Box Factor TFE3 as a Functional Partner for the E2F3 Transcription Factor |journal=Mol. Cell. Biol. |volume=23 |issue= 11 |pages= 3707–20 |year= 2003 |pmid= 12748276 |doi=10.1128/MCB.23.11.3707-3720.2003 | pmc=155231 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Qi ZY, Li Y, Ying K, etal |title=Isolation of novel differentially expressed genes related to human glioma using cDNA microarray and characterizations of two novel full-length genes |journal=J. Neurooncol. |volume=56 |issue= 3 |pages= 197–208 |year= 2002 |pmid= 12061725 |doi=10.1023/A:1015079705841 |s2cid=23878825 }}
- {{cite journal |vauthors=Yu J, Yu L, Chen Z, etal |title=Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors |journal=Brain Res. Mol. Brain Res. |volume=99 |issue= 2 |pages= 145–9 |year= 2002 |pmid= 11978406 |doi=10.1016/S0169-328X(02)00104-3 }}
- {{cite journal | vauthors=Scarpetta MA, Uhler MD |title=Evidence for two additional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse |journal=J. Biol. Chem. |volume=268 |issue= 15 |pages= 10927–31 |year= 1993 |doi=10.1016/S0021-9258(18)82074-9 |pmid= 7684369 |doi-access=free }}
- {{cite journal |vauthors=Van Patten SM, Ng DC, Th'ng JP, etal |title=Molecular cloning of a rat testis form of the inhibitor protein of cAMP-dependent protein kinase |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 12 |pages= 5383–7 |year= 1991 |pmid= 2052616 |doi=10.1073/pnas.88.12.5383 | pmc=51877 |doi-access=free |bibcode=1991PNAS...88.5383V }}
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