PLC

• Platoon Leaders Class, of the US Marine Corps Officer Candidates School
• Post Leaving Certificate, a qualification in Ireland
• Presbyterian Ladies' College (disambiguation), several schools in Australia
• Professional learning community, for collaborative learning

• Perlecan, a protein in humans
• Peptide loading complex, an intracellular membrane protein matrix
• Peter Lougheed Centre, a hospital in Calgary, Alberta, Canada
• Phospholipase C, a class of membrane-associated enzymes
• Pityriasis lichenoides chronica, a skin condition
• Posterolateral corner, a region of the human knee

• Colombian Liberal Party ({{langx|es|Partido Liberal Colombiano|link=no}})
• Conservative Party (Spain) ({{langx|es|Partido Liberal-Conservador|link=no}})
• Constitutionalist Liberal Party ({{langx|es|Partido Liberal Constitucionalista|link=no}}), in Nicaragua
• Liberal Party of Canada ({{langx|fr|Parti Libéral du Canada|link=no}})
• Palestinian Legislative Council, of the Palestinian Authority
• Pennsylvania Leadership Conference, in the US
• Provisional Legislative Council, in Hong Kong 1997–1998

• Packet loss concealment, in VoIP communications
• Planar lightwave circuit splitter, a type of fiber-optic splitter
• Portevin–Le Chatelier effect, jerky flow under plastic deformation
• Power-line communication, or power-line carrier
• Product lifecycle, from inception to manufacture
• Programmable logic controller, an industrial digital computer

• Pine Lake Camp, a Salvation Army camp in Alberta, Canada
• Polish–Lithuanian Commonwealth
• Portland Lesbian Choir, in Oregon, US
• Prism Leisure Corporation, a former British company
• UAE Pro League Committee, a football organising committee

• PL/C, a programming language

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