Login
Login

PLCB3

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an enzyme that in humans is encoded by the PLCB3 gene.{{cite journal | vauthors = Weber G, Friedman E, Grimmond S, Hayward NK, Phelan C, Skogseid B, Gobl A, Zedenius J, Sandelin K, Teh BT | title = The phospholipase C beta 3 gene located in the MEN1 region shows loss of expression in endocrine tumours | journal = Hum. Mol. Genet. | volume = 3 | issue = 10 | pages = 1775–81 | date = March 1995 | pmid = 7849701 | doi = 10.1093/hmg/3.10.1775 }}{{cite web | title = Entrez Gene: PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5331}}

The gene codes for the enzyme phospholipase C β3. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This enzyme is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.

Interactions

PLCB3 has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2.{{cite journal | vauthors = Hwang JI, Heo K, Shin KJ, Kim E, Yun C, Ryu SH, Shin HS, Suh PG | title = Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2 | journal = J. Biol. Chem. | volume = 275 | issue = 22 | pages = 16632–7 | date = June 2000 | pmid = 10748023 | doi = 10.1074/jbc.M001410200 | doi-access = free }}

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal | vauthors = Carozzi AJ, Kriz RW, Webster C, Parker PJ | title = Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily | journal = Eur. J. Biochem. | volume = 210 | issue = 2 | pages = 521–9 | year = 1992 | pmid = 1333955 | doi = 10.1111/j.1432-1033.1992.tb17450.x | doi-access = }}
  • {{cite journal | vauthors = Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G | title = Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway | journal = J. Clin. Invest. | volume = 86 | issue = 6 | pages = 2117–24 | year = 1990 | pmid = 1979339 | pmc = 329852 | doi = 10.1172/JCI114950 }}
  • {{cite journal | vauthors = Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S | title = Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line | journal = Eur. J. Immunol. | volume = 25 | issue = 9 | pages = 2695–700 | year = 1995 | pmid = 7589147 | doi = 10.1002/eji.1830250944 | s2cid = 20562627 }}
  • {{cite journal | vauthors = Lagercrantz J, Carson E, Phelan C, Grimmond S, Rosén A, Daré E, Nordenskjöld M, Hayward NK, Larsson C, Weber G | title = Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3) | journal = Genomics | volume = 26 | issue = 3 | pages = 467–72 | year = 1995 | pmid = 7607669 | doi = 10.1016/0888-7543(95)80164-H }}
  • {{cite journal | vauthors = Mazuruk K, Schoen TJ, Chader GJ, Rodriguez IR | title = Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene | journal = Biochem. Biophys. Res. Commun. | volume = 212 | issue = 1 | pages = 190–5 | year = 1995 | pmid = 7612006 | doi = 10.1006/bbrc.1995.1955 | url = https://zenodo.org/record/1229464 }}
  • {{cite journal | vauthors = Sinke RJ, Geurts van Kessel AG | title = Localization of the human phosphatidylinositol-specific phospholipase c beta 3 gene (PLCB3) within chromosome band 11q13 | journal = Genomics | volume = 25 | issue = 2 | pages = 568–9 | year = 1995 | pmid = 7789993 | doi = 10.1016/0888-7543(95)80060-Y }}
  • {{cite journal | vauthors = Chen P, Mayne M, Power C, Nath A | title = The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases | journal = J. Biol. Chem. | volume = 272 | issue = 36 | pages = 22385–8 | year = 1997 | pmid = 9278385 | doi = 10.1074/jbc.272.36.22385 | doi-access = free }}
  • {{cite journal | vauthors = Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP | title = GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain | journal = J. Biol. Chem. | volume = 273 | issue = 28 | pages = 17749–55 | year = 1998 | pmid = 9651375 | doi = 10.1074/jbc.273.28.17749 | doi-access = free }}
  • {{cite journal | vauthors = Wang S, Zhou Y, Lukinius A, Oberg K, Skogseid B, Gobl A | title = Molecular cloning and characterization of a cDNA encoding mouse phospholipase C-beta3 | journal = Biochim. Biophys. Acta | volume = 1393 | issue = 1 | pages = 173–8 | year = 1998 | pmid = 9714794 | doi = 10.1016/s0005-2760(98)00074-5 }}
  • {{cite journal | vauthors = Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C | title = HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease | journal = Neuroimmunomodulation | volume = 5 | issue = 3–4 | pages = 184–92 | year = 1998 | pmid = 9730685 | doi = 10.1159/000026336 | s2cid = 19529677 }}
  • {{cite journal | vauthors = Haughey NJ, Holden CP, Nath A, Geiger JD | title = Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat | journal = J. Neurochem. | volume = 73 | issue = 4 | pages = 1363–74 | year = 1999 | pmid = 10501179 | doi = 10.1046/j.1471-4159.1999.0731363.x | s2cid = 25410140 | doi-access = }}
  • {{cite journal | vauthors = Hwang JI, Heo K, Shin KJ, Kim E, Yun C, Ryu SH, Shin HS, Suh PG | title = Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2 | journal = J. Biol. Chem. | volume = 275 | issue = 22 | pages = 16632–7 | year = 2000 | pmid = 10748023 | doi = 10.1074/jbc.M001410200 | doi-access = free }}
  • {{cite journal | vauthors = Wang JC, Waltner-Law M, Yamada K, Osawa H, Stifani S, Granner DK | title = Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta | journal = J. Biol. Chem. | volume = 275 | issue = 24 | pages = 18418–23 | year = 2000 | pmid = 10748198 | doi = 10.1074/jbc.M910211199 | doi-access = free }}
  • {{cite journal | vauthors = Mayne M, Holden CP, Nath A, Geiger JD | title = Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages | journal = J. Immunol. | volume = 164 | issue = 12 | pages = 6538–42 | year = 2000 | pmid = 10843712 | doi = 10.4049/jimmunol.164.12.6538 | doi-access = free }}
  • {{cite journal | vauthors = Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC | title = Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1) | journal = Biochim. Biophys. Acta | volume = 1517 | issue = 1 | pages = 63–72 | year = 2000 | pmid = 11118617 | doi = 10.1016/S0167-4781(00)00260-8 }}
  • {{cite journal | vauthors = Stålberg P, Lopez-Egido JR, Wang S, Gobl A, Oberg K, Skogseid B | title = Differentially expressed cDNAs in PLCbeta3-induced tumor suppression in a human endocrine pancreatic tumor cell line: activation of the human mismatch repair protein 3 gene | journal = Biochem. Biophys. Res. Commun. | volume = 281 | issue = 1 | pages = 227–31 | year = 2001 | pmid = 11178984 | doi = 10.1006/bbrc.2001.4329 }}
  • {{cite journal | vauthors = Xia C, Bao Z, Yue C, Sanborn BM, Liu M | title = Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases | journal = J. Biol. Chem. | volume = 276 | issue = 23 | pages = 19770–7 | year = 2001 | pmid = 11278298 | doi = 10.1074/jbc.M006266200 | doi-access = free }}
  • {{cite journal | vauthors = Yue C, Sanborn BM | title = KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser | journal = Mol. Cell. Endocrinol. | volume = 175 | issue = 1–2 | pages = 149–56 | year = 2001 | pmid = 11325525 | doi = 10.1016/S0303-7207(01)00383-5 | s2cid = 338776 }}
  • {{cite journal | vauthors = Bennasser Y, Badou A, Tkaczuk J, Bahraoui E | title = Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha | journal = Virology | volume = 303 | issue = 1 | pages = 174–80 | year = 2002 | pmid = 12482669 | doi = 10.1006/viro.2002.1676 | doi-access = free }}

{{refend}}

{{Esterases}}

{{Enzymes}}

{{Portal bar|Biology|border=no}}

Category:EC 3.1.4

{{gene-11-stub}}