PLCB4

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Two transcript variants encoding different isoforms have been found for this gene.

Oncogenic mutations in this gene have been found in cases of uveal melanoma.{{cite journal |vauthors = Johansson P, Aoude LG, Wadt K, Glasson WJ, Warrier SK, Hewitt AW, Kiilgaard JF, Heegaard S, Isaacs T, Franchina M, Ingvar C, Vermeulen T, Whitehead KJ, Schmidt CW, Palmer JM, Symmons J, Gerdes AM, Jonsson G, Hayward NK | title = Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4. | journal = Oncotarget | volume = 7 | issue = 4 | pages = 4624-31 | date = Jan 2016 | pmid = 26683228 | doi = 10.18632/oncotarget.6614 }}

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{{Esterases}}

{{Enzymes}}

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Category:EC 3.1.4

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