PLCD3

{{Short description|Protein-coding gene in the species Homo sapiens}}

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3 is an enzyme that in humans is encoded by the PLCD3 gene.{{cite journal | vauthors = Kim H, Suh PG, Ryu SH, Park SH | title = Assignment of the human PLC delta3 gene (PLCD3) to human chromosome band 17q21 by fluorescence in situ hybridization | journal = Cytogenetics and Cell Genetics | volume = 87 | issue = 3–4 | pages = 209–10 | date = Apr 2000 | pmid = 10702670 | doi = 10.1159/000015469 | s2cid = 87171791 }}{{cite journal | vauthors = Ghosh S, Pawelczyk T, Lowenstein JM | title = Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties | journal = Protein Expression and Purification | volume = 9 | issue = 2 | pages = 262–78 | date = Mar 1997 | pmid = 9056492 | doi = 10.1006/prep.1996.0682 }}{{cite web | title = Entrez Gene: PLCD3 phospholipase C, delta 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=113026}}

Function

This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP₃). Diacylglycerol and IP₃ mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca²⁺ concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids.

References

{{cite journal | vauthors = Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G | title = Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway | journal = The Journal of Clinical Investigation | volume = 86 | issue = 6 | pages = 2117–24 | date = Dec 1990 | pmid = 1979339 | pmc = 329852 | doi = 10.1172/JCI114950 }}
{{cite journal | vauthors = Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S | title = Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line | journal = European Journal of Immunology | volume = 25 | issue = 9 | pages = 2695–700 | date = Sep 1995 | pmid = 7589147 | doi = 10.1002/eji.1830250944 | s2cid = 20562627 }}
{{cite journal | vauthors = Chen P, Mayne M, Power C, Nath A | title = The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases | journal = The Journal of Biological Chemistry | volume = 272 | issue = 36 | pages = 22385–8 | date = Sep 1997 | pmid = 9278385 | doi = 10.1074/jbc.272.36.22385 | doi-access = free }}
{{cite journal | vauthors = Pawełczyk T, Matecki A | title = Expression, purification and kinetic properties of human recombinant phospholipase C delta 3 | journal = Acta Biochimica Polonica | volume = 44 | issue = 2 | pages = 221–9 | year = 1998 | pmid = 9360711 | doi = 10.18388/abp.1997_4417| doi-access = free }}
{{cite journal | vauthors = Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C | title = HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease | journal = Neuroimmunomodulation | volume = 5 | issue = 3–4 | pages = 184–92 | year = 1998 | pmid = 9730685 | doi = 10.1159/000026336 | s2cid = 19529677 }}
{{cite journal | vauthors = Pawelczyk T, Matecki A | title = Localization of phospholipase C delta3 in the cell and regulation of its activity by phospholipids and calcium | journal = European Journal of Biochemistry | volume = 257 | issue = 1 | pages = 169–77 | date = Oct 1998 | pmid = 9799116 | doi = 10.1046/j.1432-1327.1998.2570169.x | doi-access = free }}
{{cite journal | vauthors = Pawelczyk T, Matecki A | title = Phospholipase C-delta3 binds with high specificity to phosphatidylinositol 4,5-bisphosphate and phosphatidic acid in bilayer membranes | journal = European Journal of Biochemistry | volume = 262 | issue = 2 | pages = 291–8 | date = Jun 1999 | pmid = 10336610 | doi = 10.1046/j.1432-1327.1999.00388.x | doi-access = free }}
{{cite journal | vauthors = Haughey NJ, Holden CP, Nath A, Geiger JD | title = Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat | journal = Journal of Neurochemistry | volume = 73 | issue = 4 | pages = 1363–74 | date = Oct 1999 | pmid = 10501179 | doi = 10.1046/j.1471-4159.1999.0731363.x | s2cid = 25410140 | doi-access = free }}
{{cite journal | vauthors = Mayne M, Holden CP, Nath A, Geiger JD | title = Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages | journal = Journal of Immunology | volume = 164 | issue = 12 | pages = 6538–42 | date = Jun 2000 | pmid = 10843712 | doi = 10.4049/jimmunol.164.12.6538 | doi-access = free }}
{{cite journal | vauthors = Lin FG, Cheng HF, Lee IF, Kao HJ, Loh SH, Lee WH | title = Downregulation of phospholipase C delta3 by cAMP and calcium | journal = Biochemical and Biophysical Research Communications | volume = 286 | issue = 2 | pages = 274–80 | date = Aug 2001 | pmid = 11500033 | doi = 10.1006/bbrc.2001.5371 }}
{{cite journal | vauthors = Ananthanarayanan B, Das S, Rhee SG, Murray D, Cho W | title = Membrane targeting of C2 domains of phospholipase C-delta isoforms | journal = The Journal of Biological Chemistry | volume = 277 | issue = 5 | pages = 3568–75 | date = Feb 2002 | pmid = 11706040 | doi = 10.1074/jbc.M109705200 | doi-access = free }}
{{cite journal | vauthors = Nagase T, Kikuno R, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins | journal = DNA Research | volume = 8 | issue = 6 | pages = 319–27 | date = Dec 2001 | pmid = 11853319 | doi = 10.1093/dnares/8.6.319 | doi-access = free }}
{{cite journal | vauthors = Bennasser Y, Badou A, Tkaczuk J, Bahraoui E | title = Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha | journal = Virology | volume = 303 | issue = 1 | pages = 174–80 | date = Nov 2002 | pmid = 12482669 | doi = 10.1006/viro.2002.1676 | doi-access = free }}
{{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = Jul 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}

Category:EC 3.1.4

PLCD3

Function

References

Further reading