PLK3

Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.

PLK3 has been shown to interact with:

• CDC25C,{{cite journal | vauthors = Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W | title = The physical association and phosphorylation of Cdc25C protein phosphatase by Prk | journal = Oncogene | volume = 18 | issue = 44 | pages = 6029–36 | date = Oct 1999 | pmid = 10557092 | doi = 10.1038/sj.onc.1202983 | doi-access = free }}
• CHEK2,{{cite journal | vauthors = Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ | title = Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways | journal = Oncogene | volume = 21 | issue = 43 | pages = 6633–40 | date = Sep 2002 | pmid = 12242661 | doi = 10.1038/sj.onc.1205850 | s2cid = 24106070 | doi-access = }} and
• P53.{{cite journal | vauthors = Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W | title = Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway | journal = J. Biol. Chem. | volume = 276 | issue = 46 | pages = 43305–12 | date = Nov 2001 | pmid = 11551930 | doi = 10.1074/jbc.M106050200 | doi-access = free }}

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• {{cite journal | vauthors = Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W | title = Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas | journal = J. Biol. Chem. | volume = 271 | issue = 32 | pages = 19402–8 | year = 1996 | pmid = 8702627 | doi = 10.1074/jbc.271.32.19402 | doi-access = free }}
• {{cite journal | vauthors = Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H | title = Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216 | journal = Science | volume = 277 | issue = 5331 | pages = 1501–5 | year = 1997 | pmid = 9278512 | doi = 10.1126/science.277.5331.1501 }}
• {{cite journal | vauthors = Ouyang B, Pan H, Lu L, Li J, Stambrook P, Li B, Dai W | title = Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions | journal = J. Biol. Chem. | volume = 272 | issue = 45 | pages = 28646–51 | year = 1997 | pmid = 9353331 | doi = 10.1074/jbc.272.45.28646 | doi-access = free }}
• {{cite journal | vauthors = Kauselmann G, Weiler M, Wulff P, Jessberger S, Konietzko U, Scafidi J, Staubli U, Bereiter-Hahn J, Strebhardt K, Kuhl D | title = The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity | journal = EMBO J. | volume = 18 | issue = 20 | pages = 5528–39 | year = 1999 | pmid = 10523297 | pmc = 1171621 | doi = 10.1093/emboj/18.20.5528 }}
• {{cite journal | vauthors = Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W | title = The physical association and phosphorylation of Cdc25C protein phosphatase by Prk | journal = Oncogene | volume = 18 | issue = 44 | pages = 6029–36 | year = 1999 | pmid = 10557092 | doi = 10.1038/sj.onc.1202983 | doi-access = free }}
• {{cite journal | vauthors = Shieh SY, Ahn J, Tamai K, Taya Y, Prives C | title = The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites | journal = Genes Dev. | volume = 14 | issue = 3 | pages = 289–300 | year = 2000 | doi = 10.1101/gad.14.3.289 | pmid = 10673501 | pmc = 316358 }}
• {{cite journal | vauthors = Dai W, Li Y, Ouyang B, Pan H, Reissmann P, Li J, Wiest J, Stambrook P, Gluckman JL, Noffsinger A, Bejarano P | title = PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer | journal = Genes Chromosomes Cancer | volume = 27 | issue = 3 | pages = 332–6 | year = 2000 | pmid = 10679924 | doi = 10.1002/(SICI)1098-2264(200003)27:3<332::AID-GCC15>3.0.CO;2-K | s2cid = 20642025 }}
• {{cite journal | vauthors = Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ | title = Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 19 | pages = 10389–94 | year = 2000 | pmid = 10973490 | pmc = 27034 | doi = 10.1073/pnas.190030497 | bibcode = 2000PNAS...9710389M | doi-access = free }}
• {{cite journal | vauthors = Holtrich U, Wolf G, Yuan J, Bereiter-Hahn J, Karn T, Weiler M, Kauselmann G, Rehli M, Andreesen R, Kaufmann M, Kuhl D, Strebhardt K | title = Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages | journal = Oncogene | volume = 19 | issue = 42 | pages = 4832–9 | year = 2000 | pmid = 11039900 | doi = 10.1038/sj.onc.1203845 | s2cid = 25807289 | doi-access = }}
• {{cite journal | vauthors = Bulavin DV, Higashimoto Y, Popoff IJ, Gaarde WA, Basrur V, Potapova O, Appella E, Fornace AJ | title = Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase | journal = Nature | volume = 411 | issue = 6833 | pages = 102–7 | year = 2001 | pmid = 11333986 | doi = 10.1038/35075107 | bibcode = 2001Natur.411..102B | s2cid = 4410763 }}
• {{cite journal | vauthors = Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W | title = Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway | journal = J. Biol. Chem. | volume = 276 | issue = 46 | pages = 43305–12 | year = 2001 | pmid = 11551930 | doi = 10.1074/jbc.M106050200 | doi-access = free }}
• {{cite journal | vauthors = Latonen L, Taya Y, Laiho M | title = UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts | journal = Oncogene | volume = 20 | issue = 46 | pages = 6784–93 | year = 2001 | pmid = 11709713 | doi = 10.1038/sj.onc.1204883 | doi-access = free }}
• {{cite journal | vauthors = Ahn JY, Li X, Davis HL, Canman CE | title = Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain | journal = J. Biol. Chem. | volume = 277 | issue = 22 | pages = 19389–95 | year = 2002 | pmid = 11901158 | doi = 10.1074/jbc.M200822200 | doi-access = free }}
• {{cite journal | vauthors = Sumara I, Vorlaufer E, Stukenberg PT, Kelm O, Redemann N, Nigg EA, Peters JM | title = The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase | journal = Mol. Cell | volume = 9 | issue = 3 | pages = 515–25 | year = 2002 | pmid = 11931760 | doi = 10.1016/S1097-2765(02)00473-2 | doi-access = free }}
• {{cite journal | vauthors = Wang Q, Xie S, Chen J, Fukasawa K, Naik U, Traganos F, Darzynkiewicz Z, Jhanwar-Uniyal M, Dai W | title = Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity | journal = Mol. Cell. Biol. | volume = 22 | issue = 10 | pages = 3450–9 | year = 2002 | pmid = 11971976 | pmc = 133784 | doi = 10.1128/MCB.22.10.3450-3459.2002 }}
• {{cite journal | vauthors = Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ | title = Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways | journal = Oncogene | volume = 21 | issue = 43 | pages = 6633–40 | year = 2002 | pmid = 12242661 | doi = 10.1038/sj.onc.1205850 | s2cid = 24106070 | doi-access = }}
• {{cite journal | vauthors = Tsvetkov L, Xu X, Li J, Stern DF | title = Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody | journal = J. Biol. Chem. | volume = 278 | issue = 10 | pages = 8468–75 | year = 2003 | pmid = 12493754 | doi = 10.1074/jbc.M211202200 | doi-access = free }}
• {{cite journal | vauthors = Xie S, Wu H, Wang Q, Kunicki J, Thomas RO, Hollingsworth RE, Cogswell J, Dai W | title = Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2 | journal = Cell Cycle | volume = 1 | issue = 6 | pages = 424–9 | year = 2003 | pmid = 12548019 | doi = 10.4161/cc.1.6.271 | doi-access = free }}
• {{cite journal | vauthors = Bahassi el M, Hennigan RF, Myer DL, Stambrook PJ | title = Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation | journal = Oncogene | volume = 23 | issue = 15 | pages = 2658–63 | year = 2004 | pmid = 14968113 | doi = 10.1038/sj.onc.1207425 | doi-access = free }}

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{{Serine/threonine-specific protein kinases}}

{{Enzymes}}

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Category:EC 2.7.11

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