PLXNB1

Within neural tissues, the plexin family serves as transmembrane receptors for Semaphorins.{{cite journal | vauthors = Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG | title = B plexins activate Rho through PDZ-RhoGEF. | journal = FEBS Letters | volume = 529 | issue = 2–3 | pages = 168–72 | date = Oct 9, 2002 | pmid = 12372594 | doi = 10.1016/s0014-5793(02)03323-9 | s2cid = 26525009 | doi-access = free }} Outside of neural tissues, Plexin B1 is implicated in the control of cell migration.{{cite journal | vauthors = Basile JR, Afkhami T, Gutkind JS | title = Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway. | journal = Molecular and Cellular Biology | volume = 25 | issue = 16 | pages = 6889–98 | date = Aug 2005 | pmid = 16055703 | pmc = 1190270 | doi = 10.1128/mcb.25.16.6889-6898.2005 }}

PLXNB1 has been shown to interact with ARHGEF12,{{cite journal | vauthors = Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S | title = Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors | journal = Biochem. Biophys. Res. Commun. | volume = 297 | issue = 1 | pages = 32–7 | date = Sep 2002 | pmid = 12220504 | doi = 10.1016/S0006-291X(02)02122-8 }} Rnd1{{cite journal | vauthors = Oinuma I, Katoh H, Harada A, Negishi M | title = Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells | journal = J. Biol. Chem. | volume = 278 | issue = 28 | pages = 25671–7 | date = Jul 2003 | pmid = 12730235 | doi = 10.1074/jbc.M303047200 | doi-access = free }} and ARHGEF11.{{cite journal | vauthors = Perrot V, Vazquez-Prado J, Gutkind JS | title = Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF | journal = J. Biol. Chem. | volume = 277 | issue = 45 | pages = 43115–20 | date = Nov 2002 | pmid = 12183458 | doi = 10.1074/jbc.M206005200 | doi-access = free }}{{cite journal | vauthors = Swiercz JM, Kuner R, Behrens J, Offermanns S | title = Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology | journal = Neuron | volume = 35 | issue = 1 | pages = 51–63 | date = Jul 2002 | pmid = 12123608 | doi = 10.1016/S0896-6273(02)00750-X | s2cid = 18981429 | doi-access = free }}

{{reflist}}

• Chapoval SP, Hritzo M, Qi X, Tamagnone L, Golding A and Keegan AD. "Semaphorin 4A Stabilizes Human Regulatory T Cell Phenotype via Plexin B1". ImmunoHorizons, February 1, 2019, 3 (2) 71-87; {{doi|10.4049/immunohorizons.1800026}}

{{refbegin | 2}}

• {{cite journal | vauthors = Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 4 | issue = 5 | pages = 307–13 | year = 1998 | pmid = 9455477 | doi = 10.1093/dnares/4.5.307 | doi-access = free }}
• {{cite journal | vauthors = Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM | title = Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates | journal = Cell | volume = 99 | issue = 1 | pages = 71–80 | year = 1999 | pmid = 10520995 | doi = 10.1016/S0092-8674(00)80063-X | s2cid = 17386412 | doi-access = free }}
• {{cite journal | vauthors = Vikis HG, Li W, Guan KL | title = The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding | journal = Genes Dev. | volume = 16 | issue = 7 | pages = 836–45 | year = 2002 | pmid = 11937491 | pmc = 186329 | doi = 10.1101/gad.966402 }}
• {{cite journal | vauthors = Swiercz JM, Kuner R, Behrens J, Offermanns S | title = Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology | journal = Neuron | volume = 35 | issue = 1 | pages = 51–63 | year = 2002 | pmid = 12123608 | doi = 10.1016/S0896-6273(02)00750-X | s2cid = 18981429 | doi-access = free }}
• {{cite journal | vauthors = Perrot V, Vazquez-Prado J, Gutkind JS | title = Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF | journal = J. Biol. Chem. | volume = 277 | issue = 45 | pages = 43115–20 | year = 2003 | pmid = 12183458 | doi = 10.1074/jbc.M206005200 | doi-access = free }}
• {{cite journal | vauthors = Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL | title = The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 19 | pages = 12085–90 | year = 2002 | pmid = 12196628 | pmc = 129402 | doi = 10.1073/pnas.142433199 | bibcode = 2002PNAS...9912085A | doi-access = free }}
• {{cite journal | vauthors = Giordano S, Corso S, Conrotto P, Artigiani S, Gilestro G, Barberis D, Tamagnone L, Comoglio PM | title = The semaphorin 4D receptor controls invasive growth by coupling with Met | journal = Nat. Cell Biol. | volume = 4 | issue = 9 | pages = 720–4 | year = 2002 | pmid = 12198496 | doi = 10.1038/ncb843 | s2cid = 130071 }}
• {{cite journal | vauthors = Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S | title = Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors | journal = Biochem. Biophys. Res. Commun. | volume = 297 | issue = 1 | pages = 32–7 | year = 2002 | pmid = 12220504 | doi = 10.1016/S0006-291X(02)02122-8 }}
• {{cite journal | vauthors = Granziero L, Circosta P, Scielzo C, Frisaldi E, Stella S, Geuna M, Giordano S, Ghia P, Caligaris-Cappio F | title = CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes | journal = Blood | volume = 101 | issue = 5 | pages = 1962–9 | year = 2003 | pmid = 12406905 | doi = 10.1182/blood-2002-05-1339 | doi-access = free }}
• {{cite journal | vauthors = Artigiani S, Barberis D, Fazzari P, Longati P, Angelini P, van de Loo JW, Comoglio PM, Tamagnone L | title = Functional regulation of semaphorin receptors by proprotein convertases | journal = J. Biol. Chem. | volume = 278 | issue = 12 | pages = 10094–101 | year = 2003 | pmid = 12533544 | doi = 10.1074/jbc.M210156200 | doi-access = free}}
• {{cite journal | vauthors = Usui H, Taniguchi M, Yokomizo T, Shimizu T | title = Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains | journal = Biochem. Biophys. Res. Commun. | volume = 300 | issue = 4 | pages = 927–31 | year = 2003 | pmid = 12559962 | doi = 10.1016/S0006-291X(02)02966-2 }}
• {{cite journal | vauthors = Oinuma I, Katoh H, Harada A, Negishi M | title = Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells | journal = J. Biol. Chem. | volume = 278 | issue = 28 | pages = 25671–7 | year = 2003 | pmid = 12730235 | doi = 10.1074/jbc.M303047200 | doi-access = free }}
• {{cite journal | vauthors = Conrotto P, Corso S, Gamberini S, Comoglio PM, Giordano S | title = Interplay between scatter factor receptors and B plexins controls invasive growth | journal = Oncogene | volume = 23 | issue = 30 | pages = 5131–7 | year = 2004 | pmid = 15184888 | doi = 10.1038/sj.onc.1207650 | s2cid = 24596233 | doi-access = }}
• {{cite journal | vauthors = Swiercz JM, Kuner R, Offermanns S | title = Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2 | journal = J. Cell Biol. | volume = 165 | issue = 6 | pages = 869–80 | year = 2004 | pmid = 15210733 | pmc = 2172401 | doi = 10.1083/jcb.200312094 }}
• {{cite journal | vauthors = Oinuma I, Ishikawa Y, Katoh H, Negishi M | title = The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras | journal = Science | volume = 305 | issue = 5685 | pages = 862–5 | year = 2004 | pmid = 15297673 | doi = 10.1126/science.1097545 | bibcode = 2004Sci...305..862O | s2cid = 39544623 }}
• {{cite journal | vauthors = Conrotto P, Valdembri D, Corso S, Serini G, Tamagnone L, Comoglio PM, Bussolino F, Giordano S | title = Sema4D induces angiogenesis through Met recruitment by Plexin B1 | journal = Blood | volume = 105 | issue = 11 | pages = 4321–9 | year = 2005 | pmid = 15632204 | doi = 10.1182/blood-2004-07-2885 | doi-access = free }}

{{refend}}

• {{PDBe-KB2|O43157|Plexin-B1}}

{{gene-3-stub}}