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PNRC1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Proline-rich nuclear receptor coactivator 1 is a protein that, in humans, is encoded by the PNRC1 gene.{{cite journal | vauthors = Chen J, Liu L, Pohajdak B | title = Cloning a cDNA from human NK/T cells which codes for a protein with high proline content | journal = Biochim Biophys Acta | volume = 1264 | issue = 1 | pages = 19–22 |date=Dec 1995 | pmid = 7578250 | doi = 10.1016/0167-4781(95)00159-e}}{{cite web | title = Entrez Gene: PNRC1 proline-rich nuclear receptor coactivator 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10957}}

Function

PNRC1 functions as a coactivator for several nuclear receptors including AR, ERα, ERRα, ERRγ, GR, SF1, PR, TR, RAR and RXR.{{cite journal | vauthors = Zhou D, Quach KM, Yang C, Lee SY, Pohajdak B, Chen S | title = PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1) | journal = Mol. Endocrinol. | volume = 14 | issue = 7 | pages = 986–98 |date=July 2000 | doi = 10.1210/mend.14.7.0480 | pmid = 10894149 | doi-access = free }}{{cite journal | vauthors = Zhou D, Chen S | title = PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif | journal = Nucleic Acids Res. | volume = 29 | issue = 19 | pages = 3939–48 |date=October 2001 | pmid = 11574675 | pmc = 60244 | doi = 10.1093/nar/29.19.3939 }} The interaction between PNRC1 with nuclear receptors occurs through the SH3 domain of PNRC1.

References

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Further reading

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  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal | vauthors=Zhou D, Chen B, Ye JJ, Chen S |title=A novel crosstalk mechanism between nuclear receptor-mediated and growth factor/Ras-mediated pathways through PNRC-Grb2 interaction |journal=Oncogene |volume=23 |issue= 31 |pages= 5394–404 |year= 2004 |pmid= 15122321 |doi= 10.1038/sj.onc.1207695 |doi-access= free }}
  • {{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |bibcode=2003Natur.425..805M |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | vauthors=Hsiao PW, Chang C |title=Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells |journal=J. Biol. Chem. |volume=274 |issue= 32 |pages= 22373–9 |year= 1999 |pmid= 10428808 |doi=10.1074/jbc.274.32.22373 |citeseerx=10.1.1.621.2877 |s2cid=15532327 |doi-access=free }}

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External links

  • {{MeshName|PNRC1+protein,+human|3=PNRC1 protein, human}}
  • {{NURSA|C108}}

{{Transcription coregulators}}

Category:Gene expression

Category:Transcription coregulators

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