Login
Login

PODXL2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Podocalyxin like 2 is a protein that in humans is encoded by the PODXL2 gene.

{{cite web

| title = Entrez Gene: Podocalyxin like 2

| url = https://www.ncbi.nlm.nih.gov/gene/50512

| access-date = 2017-10-11

}}

Structure

This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012].

Function

Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal |vauthors=Fieger CB, Sassetti CM, Rosen SD |title=Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x |journal=J. Biol. Chem. |volume=278 |issue=30 |pages=27390–8 |year=2003 |pmid=12889478 |doi=10.1074/jbc.M304204200 |doi-access=free }}

{{refend}}

{{gene-3-stub}}

{{NLM content}}