Login
Login

POLDIP3

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{cs1 config|name-list-style=vanc}}

{{Technical|date=October 2009}}

{{Infobox_gene}}

Polymerase delta-interacting protein 3 is an enzyme that in humans is encoded by the POLDIP3 gene.{{Cite journal|vauthors=Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY | title = Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen | journal = J Biol Chem | volume = 278 | issue = 12 | pages = 10041–7 |date=Mar 2003 | pmid = 12522211 | doi = 10.1074/jbc.M208694200 | doi-access = free }}{{Cite web| title = Entrez Gene: POLDIP3 polymerase (DNA-directed), delta interacting protein 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84271}}

This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified.

Interactions

POLDIP3 has been shown to interact with P70-S6 Kinase 1.{{Cite journal|last=Richardson |first=Celeste J |author2=Bröenstrup Mark |author3=Fingar Diane C |author4=Jülich Kristina |author5=Ballif Bryan A |author6=Gygi Steven |author7=Blenis John |date=Sep 2004 |title=SKAR is a specific target of S6 kinase 1 in cell growth control |journal=Curr. Biol. |volume=14 |issue=17 |pages=1540–9 |location = England| issn = 0960-9822| pmid = 15341740 |doi = 10.1016/j.cub.2004.08.061 |doi-access=free |bibcode=2004CBio...14.1540R }}

References

{{Reflist}}

Further reading

{{Refbegin| 2}}

  • {{Cite journal |vauthors=Dunham I, Shimizu N, Roe BA, etal |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 |bibcode=1999Natur.402..489D |doi-access=free }}
  • {{Cite journal |vauthors=Hirosawa M, Nagase T, Murahashi Y, etal |title=Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. |journal=DNA Res. |volume=8 |issue= 1 |pages= 1–9 |year= 2001 |pmid= 11258795 |doi=10.1093/dnares/8.1.1 |citeseerx=10.1.1.321.2497 }}
  • {{Cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{Cite journal |vauthors=Collins JE, Goward ME, Cole CG, etal |title=Reevaluating human gene annotation: a second-generation analysis of chromosome 22. |journal=Genome Res. |volume=13 |issue= 1 |pages= 27–36 |year= 2003 |pmid= 12529303 |doi= 10.1101/gr.695703 | pmc=430954 }}
  • {{Cite journal |vauthors=Richardson CJ, Bröenstrup M, Fingar DC, etal |title=SKAR is a specific target of S6 kinase 1 in cell growth control. |journal=Curr. Biol. |volume=14 |issue= 17 |pages= 1540–9 |year= 2005 |pmid= 15341740 |doi= 10.1016/j.cub.2004.08.061 |doi-access= free |bibcode=2004CBio...14.1540R }}
  • {{Cite journal |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 |doi-access=free }}
  • {{Cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{Cite journal |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |bibcode=2005Natur.433...77A |s2cid=4344740 }}
  • {{Cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
  • {{Cite journal |vauthors=Smyk A, Szuminska M, Uniewicz KA, etal |title=Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth. |journal=FEBS J. |volume=273 |issue= 20 |pages= 4728–41 |year= 2006 |pmid= 16984396 |doi= 10.1111/j.1742-4658.2006.05477.x |doi-access= free }}

{{Refend}}

{{Gene-22-stub}}