Login
Login

POLE2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

DNA polymerase epsilon subunit 2 is an enzyme that in humans is encoded by the POLE2 gene.{{cite journal | vauthors = Li Y, Asahara H, Patel VS, Zhou S, Linn S | title = Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon | journal = J Biol Chem | volume = 272 | issue = 51 | pages = 32337–44 | date = Jan 1998 | pmid = 9405441 | doi = 10.1074/jbc.272.51.32337 | doi-access = free }}{{cite journal | vauthors = Jokela M, Mäkiniemi M, Lehtonen S, Szpirer C, Hellman U, Syväoja JE | title = The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon | journal = Nucleic Acids Res | volume = 26 | issue = 3 | pages = 730–4 | date = Mar 1998 | pmid = 9443964 | pmc = 147316 | doi = 10.1093/nar/26.3.730 }}{{cite web | title = Entrez Gene: POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5427}}

Interactions

POLE2 has been shown to interact with SAP18.{{cite journal | vauthors = Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F | title = The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA | journal = J. Biochem. | volume = 131 | issue = 3 | pages = 307–11 | date = Mar 2002 | pmid = 11872158 | doi = 10.1093/oxfordjournals.jbchem.a003104 }}

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | year = 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 | hdl = 11858/00-001M-0000-0010-8592-0 | s2cid = 8235923 | hdl-access = free }}
  • {{cite journal | vauthors = Post SM, Tomkinson AE, Lee EY |author3-link=Eva Y.-H. P. Lee | title = The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase ε | journal = Nucleic Acids Res. | volume = 31 | issue = 19 | pages = 5568–75 | year = 2003 | pmid = 14500819 | pmc = 206465 | doi = 10.1093/nar/gkg765 }}
  • {{cite journal | vauthors = Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F | title = The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA | journal = J. Biochem. | volume = 131 | issue = 3 | pages = 307–11 | year = 2002 | pmid = 11872158 | doi = 10.1093/oxfordjournals.jbchem.a003104 }}
  • {{cite journal | vauthors = Huang D, Jokela M, Tuusa J, Skog S, Poikonen K, Syväoja JE | title = E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase ɛ B-subunit gene POLE2 | journal = Nucleic Acids Res. | volume = 29 | issue = 13 | pages = 2810–21 | year = 2001 | pmid = 11433027 | pmc = 55767 | doi = 10.1093/nar/29.13.2810 }}
  • {{cite journal | vauthors = Li Y, Pursell ZF, Linn S | title = Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon | journal = J. Biol. Chem. | volume = 275 | issue = 30 | pages = 23247–52 | year = 2000 | pmid = 10801849 | doi = 10.1074/jbc.M002548200 | doi-access = free }}

{{refend}}

External links

  • [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P56282 PDBe-KB] provides an overview of all the structure information available in the PDB for Human DNA polymerase epsilon subunit 2 (POLE2)

{{DNA replication|state=collapsed}}

{{gene-14-stub}}