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POLE3

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.{{cite journal | vauthors = Li Y, Pursell ZF, Linn S | title = Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon | journal = J Biol Chem | volume = 275 | issue = 30 | pages = 23247–52 |date=Aug 2000 | pmid = 10801849 | doi = 10.1074/jbc.M002548200 | doi-access = free }}{{cite journal | vauthors = Poot RA, Dellaire G, Hulsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD | title = HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins | journal = EMBO J | volume = 19 | issue = 13 | pages = 3377–87 |date=Oct 2000 | pmid = 10880450 | pmc = 313940 | doi = 10.1093/emboj/19.13.3377 }}{{cite web | title = Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54107}}

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM]{{cite web | title = Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54107}}

Interactions

POLE3 has been shown to interact with SMARCA5.

References

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Further reading

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  • {{cite journal |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
  • {{cite journal |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 }}
  • {{cite journal | vauthors=Bolognese F, Imbriano C, Caretti G, Mantovani R |title=Cloning and characterization of the histone-fold proteins YBL1 and YCL1. |journal=Nucleic Acids Res. |volume=28 |issue= 19 |pages= 3830–8 |year= 2000 |pmid= 11000277 |doi=10.1093/nar/28.19.3830 | pmc=110757 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | vauthors=Post SM, Tomkinson AE, Lee EY |author3-link=Eva Y.-H. P. Lee |title=The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon. |journal=Nucleic Acids Res. |volume=31 |issue= 19 |pages= 5568–75 |year= 2003 |pmid= 14500819 |doi=10.1093/nar/gkg765 | pmc=206465 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Humphray SJ, Oliver K, Hunt AR, etal |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 |bibcode=2004Natur.429..369H }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
  • {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}

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