POLE4

{{Short description|Protein-coding gene in the species Homo sapiens}}

Polymerase (DNA-directed), epsilon 4, accessory subunit is a protein that in humans is encoded by the POLE4 gene.{{cite web | title = Entrez Gene: Polymerase (DNA-directed), epsilon 4, accessory subunit

| url = https://www.ncbi.nlm.nih.gov/gene/56655 }}

Function

POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.

References

{{cite journal |vauthors=Post SM, Tomkinson AE, Lee EY |author3-link=Eva Y.-H. P. Lee | title = The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon | journal = Nucleic Acids Res. | volume = 31 | issue = 19 | pages = 5568–75 | year = 2003 | pmid = 14500819 | pmc = 206465 | doi = 10.1093/nar/gkg765}}
{{cite journal |vauthors=Li Y, Pursell ZF, Linn S | title = Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon | journal = J. Biol. Chem. | volume = 275 | issue = 30 | pages = 23247–52 | year = 2000 | pmid = 10801849 | doi = 10.1074/jbc.M002548200 | doi-access = free }}
{{cite journal |vauthors=Wang YL, Faiola F, Xu M, Pan S, Martinez E | title = Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein | journal = J. Biol. Chem. | volume = 283 | issue = 49 | pages = 33808–15 | year = 2008 | pmid = 18838386 | pmc = 2590711 | doi = 10.1074/jbc.M806936200 | doi-access = free }}

POLE4

Function

References

Further reading