POLR2J2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
DNA directed RNA polymerase II polypeptide J-related gene, also known as POLR2J2, is a human gene.{{cite web | title = Entrez Gene: POLR2J2 DNA directed RNA polymerase II polypeptide J-related gene| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=246721}}
This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J.
Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo.
References
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Further reading
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- {{cite journal |vauthors=Shpakovskii DG, Shematorova EK, Shpakovskii GV |title=Human PMS2 gene family: origin, molecular evolution, and biological implications |journal=Dokl. Biochem. Biophys. |volume=408 |pages= 175–179 |year= 2006 |pmid= 16913423 |doi=10.1134/S1607672906030185 |s2cid=30897463 }}
- {{cite journal | author=Benga WJ |title=Distinct regions of RPB11 are required for heterodimerization with RPB3 in human and yeast RNA polymerase II |journal=Nucleic Acids Res. |volume=33 |issue= 11 |pages= 3582–3590 |year= 2005 |pmid= 15987790 |doi= 10.1093/nar/gki672 | pmc=1159119 |name-list-style=vanc| author2=Grandemange S | author3=Shpakovski GV | display-authors=3 | last4=Shematorova | first4=EK | last5=Kedinger | first5=C | last6=Vigneron | first6=M }}
- {{cite journal |vauthors=Shpakovskiĭ DG, Shematorova EK, Shpakovskiĭ GV |title=[New genes on human chromosome 7: bioinformatic analysis of a gene cluster from the POLR2J family] |journal=Bioorg. Khim. |volume=30 |issue= 6 |pages= 621–5 |year= 2005 |pmid= 15586814 |doi= 10.1023/b:rubi.0000049773.14555.4c|s2cid=1452697 }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Durrin LK, Krontiris TG |title=The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11 |journal=Genomics |volume=79 |issue= 6 |pages= 809–817 |year= 2002 |pmid= 12036295 |doi= 10.1006/geno.2002.6772 }}
- {{cite journal | author=Grandemange S |title=A human RNA polymerase II subunit is encoded by a recently generated multigene family |journal=BMC Mol. Biol. |volume=2|pages= 14 |year= 2003 |pmid= 11747469 |doi=10.1186/1471-2199-2-14 | pmc=61041 |name-list-style=vanc| author2=Schaller S | author3=Yamano S | display-authors=3 | last4=Du Manoir | first4=Stanislas | last5=Shpakovski | first5=George V | last6=Mattei | first6=Marie-Geneviève | last7=Kedinger | first7=Claude | last8=Vigneron | first8=Marc |doi-access=free }}
- {{cite journal | author=Cramer P |title=Architecture of RNA polymerase II and implications for the transcription mechanism |journal=Science |volume=288 |issue= 5466 |pages= 640–649 |year= 2000 |pmid= 10784442 |doi=10.1126/science.288.5466.640 |name-list-style=vanc| author2=Bushnell DA | author3=Fu J | display-authors=3 | last4=Gnatt | first4=AL | last5=Maier-Davis | first5=B | last6=Thompson | first6=NE | last7=Burgess | first7=RR | last8=Edwards | first8=AM | last9=David | first9=PR |bibcode=2000Sci...288..640C |hdl=11858/00-001M-0000-0015-872F-3 | hdl-access=free }}
- {{cite journal |title=Toward a complete human genome sequence |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi= 10.1101/gr.8.11.1097|last1=Sanger Centre |first1=The |last2=Washington University Genome Sequencing Cente |first2=The |doi-access=free }}
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