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POLR3C

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

DNA-directed RNA polymerase III subunit RPC3 is an enzyme that in humans is encoded by the POLR3C gene.{{cite journal | vauthors = Wang Z, Roeder RG | title = Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation | journal = Genes & Development | volume = 11 | issue = 10 | pages = 1315–26 | date = May 1997 | pmid = 9171375 | doi = 10.1101/gad.11.10.1315 | doi-access = free }}{{cite journal | vauthors = Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N | title = Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits | journal = Molecular and Cellular Biology | volume = 22 | issue = 22 | pages = 8044–55 | date = November 2002 | pmid = 12391170 | pmc = 134740 | doi = 10.1128/MCB.22.22.8044-8055.2002 | url = http://repository.cshl.edu/28722/1/Kobayashi%20Myers%20Hernandez%20Molecular%20and%20Cellular%20Biology%202002.pdf }}{{cite web | title = Entrez Gene: POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10623}}

Interactions

POLR3C has been shown to interact with GTF3C4.{{cite journal | vauthors = Hsieh YJ, Wang Z, Kovelman R, Roeder RG | title = Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III | journal = Molecular and Cellular Biology | volume = 19 | issue = 7 | pages = 4944–52 | date = July 1999 | pmid = 10373544 | pmc = 84305 | doi = 10.1128/mcb.19.7.4944 }}{{cite journal | vauthors = Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG | title = The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity | journal = Molecular and Cellular Biology | volume = 19 | issue = 11 | pages = 7697–704 | date = November 1999 | pmid = 10523658 | pmc = 84812 | doi = 10.1128/mcb.19.11.7697 }}

Related gene problems

  • TAR syndrome{{cite journal | vauthors = Klopocki E, Schulze H, Strauss G, Ott CE, Hall J, Trotier F, Fleischhauer S, Greenhalgh L, Newbury-Ecob RA, Neumann LM, Habenicht R, König R, Seemanova E, Megarbane A, Ropers HH, Ullmann R, Horn D, Mundlos S | display-authors = 6 | title = Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome | journal = American Journal of Human Genetics | volume = 80 | issue = 2 | pages = 232–40 | date = February 2007 | pmid = 17236129 | pmc = 1785342 | doi = 10.1086/510919 }}
  • 1q21.1 deletion syndrome
  • 1q21.1 duplication syndrome

References

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Further reading

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  • {{cite journal | vauthors = Jang KL, Collins MK, Latchman DS | title = The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC | journal = Journal of Acquired Immune Deficiency Syndromes | volume = 5 | issue = 11 | pages = 1142–7 | year = 1992 | pmid = 1403646 }}
  • {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
  • {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal | vauthors = Hsieh YJ, Wang Z, Kovelman R, Roeder RG | title = Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III | journal = Molecular and Cellular Biology | volume = 19 | issue = 7 | pages = 4944–52 | date = July 1999 | pmid = 10373544 | pmc = 84305 | doi = 10.1128/mcb.19.7.4944 }}
  • {{cite journal | vauthors = Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG | title = The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity | journal = Molecular and Cellular Biology | volume = 19 | issue = 11 | pages = 7697–704 | date = November 1999 | pmid = 10523658 | pmc = 84812 | doi = 10.1128/mcb.19.11.7697 }}
  • {{cite journal | vauthors = Kuwana M, Kimura K, Kawakami Y | title = Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay | journal = Arthritis and Rheumatism | volume = 46 | issue = 10 | pages = 2742–7 | date = October 2002 | pmid = 12384934 | doi = 10.1002/art.10521 | doi-access = free }}

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