Login
Login

POLR3D

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

DNA-directed RNA polymerase III subunit RPC4 is an enzyme that in humans is encoded by the POLR3D gene.{{cite journal | vauthors = Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N | title = Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits | journal = Mol Cell Biol | volume = 22 | issue = 22 | pages = 8044–55 |date=Oct 2002 | pmid = 12391170 | pmc = 134740 | doi =10.1128/MCB.22.22.8044-8055.2002 | url = http://repository.cshl.edu/28722/1/Kobayashi%20Myers%20Hernandez%20Molecular%20and%20Cellular%20Biology%202002.pdf }}{{cite journal | vauthors = Chong SS, Hu P, Hernandez N | title = Reconstitution of transcription from the human U6 small nuclear RNA promoter with eight recombinant polypeptides and a partially purified RNA polymerase III complex | journal = J Biol Chem | volume = 276 | issue = 23 | pages = 20727–34 |date=Jun 2001 | pmid = 11279001 | doi = 10.1074/jbc.M100088200 | doi-access = free }}{{cite web | title = Entrez Gene: POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=661}}

This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures.{{cite web | title = Entrez Gene: POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=661}}

Interactions

POLR3D has been shown to interact with POLR3E.

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal | vauthors=Jang KL, Collins MK, Latchman DS |title=The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC. |journal=J. Acquir. Immune Defic. Syndr. |volume=5 |issue= 11 |pages= 1142–7 |year= 1992 |pmid= 1403646 }}
  • {{cite journal |vauthors=Greco A, Ittmann M, Barletta C, etal |title=Chromosomal localization of human genes required for G1 progression in mammalian cells. |journal=Genomics |volume=4 |issue= 3 |pages= 240–5 |year= 1989 |pmid= 2714790 |doi=10.1016/0888-7543(89)90326-1 }}
  • {{cite journal | vauthors=Ittmann M, Greco A, Basilico C |title=Isolation of the human gene that complements a temperature-sensitive cell cycle mutation in BHK cells. |journal=Mol. Cell. Biol. |volume=7 |issue= 10 |pages= 3386–93 |year= 1988 |pmid= 3683386 |doi= 10.1128/MCB.7.10.3386| pmc=367988 }}
  • {{cite journal | vauthors=Jackson AJ, Ittmann M, Pugh BF |title=The BN51 protein is a polymerase (Pol)-specific subunit of RNA Pol III which reveals a link between Pol III transcription and pre-rRNA processing. |journal=Mol. Cell. Biol. |volume=15 |issue= 1 |pages= 94–101 |year= 1995 |pmid= 7799973 |doi= 10.1128/MCB.15.1.94| pmc=231913 }}
  • {{cite journal | author=Ittmann MM |title=Cell cycle control of the BN51 cell cycle gene which encodes a subunit of RNA polymerase III. |journal=Cell Growth Differ. |volume=5 |issue= 7 |pages= 783–8 |year= 1994 |pmid= 7947392 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}

{{refend}}

{{gene-8-stub}}