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POU2AF1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

POU domain class 2-associating factor 1 is a protein that in humans is encoded by the POU2AF1 gene.{{cite journal | vauthors = Junker S, Brøndum-Nielsen K, Newell JW, Matthias P, Tommerup N | title = Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization | journal = Genomics | volume = 33 | issue = 1 | pages = 143–5 | date = Jun 1996 | pmid = 8617501 | doi = 10.1006/geno.1996.0173 }}{{cite web | title = Entrez Gene: POU2AF1 POU domain, class 2, associating factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5450}} The protein is also termed Oct coactivator from B cells (i.e. OCAB), Oct binding factor 1 (OBF1 or OBF-1), and, as commonly found in the literature, BOB1.{{cite web|url=https://www.ncbi.nlm.nih.gov/gene/5450|title=POU2AF1 POU class 2 homeobox associating factor 1 [ Homo sapiens (human) ]|website=Gene|publisher=National Library of Medicine, National Center for Biotechnology Information|access-date=2 January 2024|date=23 November 2023}} BOB1 is a transcriptional coactivator (i.e. a protein that controls the activity of transcription factors) which is expressed principally by B-cell lymphocytes and controls immunoglobulin and other genes critical for these cells expression of CD20, CRISP-3, and CD36.{{cite journal | vauthors = Ponzoni M, Arrigoni G, Doglioni C | title = New transcription factors in diagnostic hematopathology | journal = Advances in Anatomic Pathology | volume = 14 | issue = 1 | pages = 25–35 | date = January 2007 | pmid = 17198308 | doi = 10.1097/PAP.0b013e31802f0495 | s2cid = 37644377 }} The expression of BOB1 has proven useful for identifying certain lymphomas as being B-cell lymphomas,{{cite journal | vauthors = Yin L, Xu J, Li M, Reddy V, Zhou Q, Liu H, Chu P, Zhang Q, Huang Q, Gao Z, Liang X, Wang HY, Pan Z | title = Oct2 and Bob1 are sensitive and specific markers in lineage determination of B cell lymphomas with no expression of conventional B cell markers | journal = Histopathology | volume = 69 | issue = 5 | pages = 775–783 | date = November 2016 | pmid = 27319306 | doi = 10.1111/his.13017 | s2cid = 12613073 }} as exemplified in studies which use BOB1 expression to help identify lymphomas as being diffuse large B-cell lymphomas, not otherwise specified.{{cite journal | vauthors = Grimm KE, O'Malley DP | title = Aggressive B cell lymphomas in the 2017 revised WHO classification of tumors of hematopoietic and lymphoid tissues | journal = Annals of Diagnostic Pathology | volume = 38 | pages = 6–10 | date = February 2019 | pmid = 30380402 | doi = 10.1016/j.anndiagpath.2018.09.014 | s2cid = 53196244 }}

Interactions

POU2AF1 has been shown to interact with:

  • POU2F1{{cite journal | vauthors = Chasman D, Cepek K, Sharp PA, Pabo CO | title = Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface | journal = Genes Dev. | volume = 13 | issue = 20 | pages = 2650–7 | date = Oct 1999 | pmid = 10541551 | pmc = 317104 | doi = 10.1101/gad.13.20.2650}}{{cite journal | vauthors = Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N | title = The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1 | journal = Mol. Cell. Biol. | volume = 18 | issue = 1 | pages = 368–77 | date = Jan 1998 | pmid = 9418884 | pmc = 121507 | doi = 10.1128/mcb.18.1.368}}{{cite journal | vauthors = Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B | title = Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator | journal = Biochemistry | volume = 40 | issue = 22 | pages = 6580–8 | date = Jun 2001 | pmid = 11380252 | doi = 10.1021/bi010095x}} and
  • SIAH1.{{cite journal | vauthors = Tiedt R, Bartholdy BA, Matthias G, Newell JW, Matthias P | title = The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1 | journal = EMBO J. | volume = 20 | issue = 15 | pages = 4143–52 | date = Aug 2001 | pmid = 11483517 | pmc = 149178 | doi = 10.1093/emboj/20.15.4143 }}{{cite journal | vauthors = Jahn L, Hombrink P, Hagedoorn RS, Kester MG, van der Steen DM, Rodriguez T, Pentcheva-Hoang T, de Ru AH, Schoonakker MP, Meeuwsen MH, Griffioen M, van Veelen PA, Falkenburg JH, Heemskerk MH | title = TCR-based therapy for multiple myeloma and other B-cell malignancies targeting intracellular transcription factor BOB1 | journal = Blood | volume = 129 | issue = 10 | pages = 1284–1295 | date = March 2017 | pmid = 28053195 | doi = 10.1182/blood-2016-09-737536 | doi-access = free }}

See also

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal | vauthors = Teitell MA | title = OCA-B regulation of B-cell development and function | journal = Trends Immunol. | volume = 24 | issue = 10 | pages = 546–53 | year = 2004 | pmid = 14552839 | doi = 10.1016/j.it.2003.08.002 }}
  • {{cite journal | vauthors = Luo Y, Roeder RG | title = Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B | journal = Mol. Cell. Biol. | volume = 15 | issue = 8 | pages = 4115–24 | year = 1995 | pmid = 7623806 | pmc = 230650 | doi = 10.1128/MCB.15.8.4115}}
  • {{cite journal | vauthors = Gstaiger M, Knoepfel L, Georgiev O, Schaffner W, Hovens CM | title = A B-cell coactivator of octamer-binding transcription factors | journal = Nature | volume = 373 | issue = 6512 | pages = 360–2 | year = 1995 | pmid = 7779176 | doi = 10.1038/373360a0 | bibcode = 1995Natur.373..360G | s2cid = 4303288 }}
  • {{cite journal | vauthors = Strubin M, Newell JW, Matthias P | title = OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins | journal = Cell | volume = 80 | issue = 3 | pages = 497–506 | year = 1995 | pmid = 7859290 | doi = 10.1016/0092-8674(95)90500-6 | s2cid = 6139601 | doi-access = free }}
  • {{cite journal | vauthors = Galiègue-Zouitina S, Quief S, Hildebrand MP, Denis C, Lecocq G, Collyn-d'Hooghe M, Bastard C, Yuille M, Dyer MJ, Kerckaert JP | title = Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3; 11) (q27; q23) chromosomal translocation | journal = Comptes Rendus de l'Académie des Sciences, Série III | volume = 318 | issue = 11 | pages = 1125–31 | year = 1996 | pmid = 8574789 }}
  • {{cite journal | vauthors = Zwilling S, Dieckmann A, Pfisterer P, Angel P, Wirth T | title = Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells | journal = Science | volume = 277 | issue = 5323 | pages = 221–5 | year = 1997 | pmid = 9211847 | doi = 10.1126/science.277.5323.221 }}
  • {{cite journal | vauthors = Sauter P, Matthias P | title = The B cell-specific coactivator OBF-1 (OCA-B, Bob-1) is inducible in T cells and its expression is dispensable for IL-2 gene induction | journal = Immunobiology | volume = 198 | issue = 1–3 | pages = 207–16 | year = 1998 | pmid = 9442392 | doi = 10.1016/S0171-2985(97)80041-1 }}
  • {{cite journal | vauthors = Luo Y, Ge H, Stevens S, Xiao H, Roeder RG | title = Coactivation by OCA-B: Definition of Critical Regions and Synergism with General Cofactors | journal = Mol. Cell. Biol. | volume = 18 | issue = 7 | pages = 3803–10 | year = 1998 | pmid = 9632764 | pmc = 108964 | doi = 10.1128/mcb.18.7.3803}}
  • {{cite journal | vauthors = Sauter P, Matthias P | title = Coactivator OBF-1 Makes Selective Contacts with Both the POU-Specific Domain and the POU Homeodomain and Acts as a Molecular Clamp on DNA | journal = Mol. Cell. Biol. | volume = 18 | issue = 12 | pages = 7397–409 | year = 1998 | pmid = 9819426 | pmc = 109321 | doi = 10.1128/MCB.18.12.7397}}
  • {{cite journal | vauthors = Chasman D, Cepek K, Sharp PA, Pabo CO | title = Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface | journal = Genes Dev. | volume = 13 | issue = 20 | pages = 2650–7 | year = 1999 | pmid = 10541551 | pmc = 317104 | doi = 10.1101/gad.13.20.2650 }}
  • {{cite journal | vauthors = Tomilin A, Reményi A, Lins K, Bak H, Leidel S, Vriend G, Wilmanns M, Schöler HR | title = Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration | journal = Cell | volume = 103 | issue = 6 | pages = 853–64 | year = 2001 | pmid = 11136971 | doi = 10.1016/S0092-8674(00)00189-6 | s2cid = 14650955 | doi-access = free | hdl = 2066/187502 | hdl-access = free }}
  • {{cite journal | vauthors = Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J, Carpenter B, Roberts S, Luisi B | title = Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator | journal = Biochemistry | volume = 40 | issue = 22 | pages = 6580–8 | year = 2001 | pmid = 11380252 | doi = 10.1021/bi010095x }}
  • {{cite journal | vauthors = Tiedt R, Bartholdy BA, Matthias G, Newell JW, Matthias P | title = The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1 | journal = EMBO J. | volume = 20 | issue = 15 | pages = 4143–52 | year = 2001 | pmid = 11483517 | pmc = 149178 | doi = 10.1093/emboj/20.15.4143 }}
  • {{cite journal | vauthors = Boehm J, He Y, Greiner A, Staudt L, Wirth T | title = Regulation of BOB.1/OBF.1 stability by SIAH | journal = EMBO J. | volume = 20 | issue = 15 | pages = 4153–62 | year = 2001 | pmid = 11483518 | pmc = 149152 | doi = 10.1093/emboj/20.15.4153 }}
  • {{cite journal | vauthors = Malone CS, Wall R | title = Bob1 (OCA-B/OBF-1) differential transactivation of the B cell-specific B29 (Ig beta) and mb-1 (Ig alpha) promoters | journal = J. Immunol. | volume = 168 | issue = 7 | pages = 3369–75 | year = 2002 | pmid = 11907094 | doi = 10.4049/jimmunol.168.7.3369 | doi-access = free }}
  • {{cite journal | vauthors = Casellas R, Jankovic M, Meyer G, Gazumyan A, Luo Y, Roeder R, Nussenzweig M | title = OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes | journal = Cell | volume = 110 | issue = 5 | pages = 575–85 | year = 2003 | pmid = 12230975 | doi = 10.1016/S0092-8674(02)00911-X | s2cid = 17887117 | doi-access = free }}
  • {{cite journal | vauthors = Schaffer A, Kim EC, Wu X, Zan H, Testoni L, Salamon S, Cerutti A, Casali P | title = Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements | journal = J. Biol. Chem. | volume = 278 | issue = 25 | pages = 23141–50 | year = 2003 | pmid = 12672812 | doi = 10.1074/jbc.M212952200 | doi-access = free }}
  • {{cite journal | vauthors = Lins K, Reményi A, Tomilin A, Massa S, Wilmanns M, Matthias P, Schöler HR | title = OBF1 enhances transcriptional potential of Oct1 | journal = EMBO J. | volume = 22 | issue = 9 | pages = 2188–98 | year = 2003 | pmid = 12727885 | pmc = 156071 | doi = 10.1093/emboj/cdg199 }}

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