POU4F3
{{Short description|Protein-coding gene in the species Homo sapiens}}
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POU domain, class 4, transcription factor 3 is a protein that in humans is encoded by the POU4F3 gene.{{cite journal | vauthors = Vahava O, Morell R, Lynch ED, Weiss S, Kagan ME, Ahituv N, Morrow JE, Lee MK, Skvorak AB, Morton CC, Blumenfeld A, Frydman M, Friedman TB, King MC, Avraham KB | title = Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans | journal = Science | volume = 279 | issue = 5358 | pages = 1950–4 |date=Apr 1998 | pmid = 9506947 | doi =10.1126/science.279.5358.1950 | s2cid = 25291858 | doi-access = free | bibcode = 1998Sci...279.1950V }}{{cite web | title = Entrez Gene: POU4F3 POU domain, class 4, transcription factor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5459}} It's a member of BRN-3 group, also known as POU family class 4.
Nomenclature
DFNA15 refers to a type of nonsyndromic deafness, with autosomal dominant inheritance.
References
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Further reading
{{refbegin | 2}}In Vivo Interplay between p27Kip1, GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice
- {{cite journal|year= 2017|title=Identification and functional analysis of common sequence variants in the DFNA15 gene, Brn-3c.|url=http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30390-X|journal=Gene|volume=400|issue= 1–2|pages= 89–97|doi= 10.1016/j.gene.2007.05.023|pmid= 17611044|vauthors=Nolan LS, Jagutpal SS, Cadge BA, etal|url-access=subscription}}
- {{cite journal|year= 2004|title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)|journal=Genome Res.|volume=14|issue= 10B|pages= 2121–7|doi= 10.1101/gr.2596504|pmc=528928|pmid= 15489334|vauthors=Gerhard DS, Wagner L, Feingold EA, etal}}
- {{cite journal|year= 2004|title=Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity|journal=Biochem. Biophys. Res. Commun.|volume=324|issue= 1|pages= 372–81|doi= 10.1016/j.bbrc.2004.09.074|pmid= 15465029|vauthors=Clough RL, Sud R, Davis-Silberman N, etal}}
- {{cite journal|year= 2003|title=The DFNA15 Deafness Mutation Affects POU4F3 Protein Stability, Localization, and Transcriptional Activity|journal=Mol. Cell. Biol.|volume=23|issue= 22|pages= 7957–64|doi=10.1128/MCB.23.22.7957-7964.2003|pmc=262385|pmid= 14585957|vauthors=Weiss S, Gottfried I, Mayrose I, etal}}
- {{cite journal|year= 2003|title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences|journal=Proc. Natl. Acad. Sci. U.S.A.|volume=99|issue= 26|pages= 16899–903|doi= 10.1073/pnas.242603899|pmc=139241|pmid= 12477932|vauthors=Strausberg RL, Feingold EA, Grouse LH, etal|bibcode=2002PNAS...9916899M |doi-access=free}}
- {{cite journal|year= 2002|title=Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma|journal=Int. J. Cancer|volume=101|issue= 2|pages= 103–10|doi= 10.1002/ijc.10554|pmid= 12209986|vauthors=Leonard JH, Cook AL, Van Gele M, etal|s2cid=20592545}}
- {{cite journal|year= 1996|title=Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development|journal=Nature|volume=381|issue= 6583|pages= 603–6|doi= 10.1038/381603a0|pmid= 8637595|vauthors=Erkman L, McEvilly RJ, Luo L, etal|bibcode=1996Natur.381..603E |s2cid=37343529}}
- {{cite journal|year= 1995|title=The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons|journal=J. Neurosci.|volume=15|issue= 7 Pt 1|pages= 4762–85|doi=10.1523/JNEUROSCI.15-07-04762.1995|pmid= 7623109|pmc=6577904|vauthors=Xiang M, Zhou L, Macke JP, etal}}
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External links
- {{MeshName|POU4F3+protein,+human}}
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{{Transcription factors|g3}}
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