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PPIL3

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Peptidyl-prolyl cis-trans isomerase-like 3 is an enzyme that in humans is encoded by the PPIL3 gene.{{cite journal | vauthors = Zhou Z, Ying K, Dai J, Tang R, Wang W, Huang Y, Zhao W, Xie Y, Mao Y | title = Molecular cloning and characterization of a novel peptidylprolyl isomerase (cyclophilin)-like gene (PPIL3) from human fetal brain | journal = Cytogenetics and Cell Genetics | volume = 92 | issue = 3–4 | pages = 231–6 | date = Jul 2001 | pmid = 11435694 | doi = 10.1159/000056909 | s2cid = 713529 }}{{cite web | title = Entrez Gene: PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53938}}

Function

This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Transcript variants derived from alternative splicing and/or alternative polyadenylation exist; some of these variants encode different isoforms.

References

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Further reading

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  • {{cite journal | vauthors = Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ | title = Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis | journal = RNA | volume = 8 | issue = 4 | pages = 426–39 | date = Apr 2002 | pmid = 11991638 | pmc = 1370266 | doi = 10.1017/S1355838202021088 }}
  • {{cite journal | vauthors = Huang LL, Zhao XM, Huang CQ, Yu L, Xia ZX | title = Structure of recombinant human cyclophilin J, a novel member of the cyclophilin family | journal = Acta Crystallographica Section D | volume = 61 | issue = Pt 3 | pages = 316–21 | date = Mar 2005 | pmid = 15735342 | doi = 10.1107/S0907444904033189 }}
  • {{cite journal | vauthors = Qi ZY, Hui GZ, Li Y, Zhou ZX, Gu SH, Ying K, Xie Y | title = cDNA microarray in isolation of novel differentially expressed genes related to human glioma and clone of a novel full-length gene | journal = Chinese Medical Journal | volume = 118 | issue = 10 | pages = 799–805 | date = May 2005 | pmid = 15989758 }}
  • {{cite journal | vauthors = Hu H, Huang CQ, Liu HL, Han Y, Yu L, Bi RC | title = Crystallization and preliminary X-ray crystallographic studies of human cyclophilin J | journal = Acta Crystallographica Section F | volume = 61 | issue = Pt 2 | pages = 216–8 | date = Feb 2005 | pmid = 16510998 | pmc = 1952245 | doi = 10.1107/S1744309105000643 }}

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{{PDB Gallery|geneid=53938}}

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