PPIP5K2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Diphosphoinositol pentakisphosphate kinase 2 is a protein that in humans is encoded by the PPIP5K2 gene.
{{cite web
| title = Entrez Gene: Diphosphoinositol pentakisphosphate kinase 2
| url = https://www.ncbi.nlm.nih.gov/gene/23262
| access-date = 2017-03-21
}}
Function
Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell signaling molecules.
HISPPD1 has both IP6 kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24) activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy et al., 2007 [PubMed 17690096]).
References
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Further reading
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- {{cite journal |vauthors=Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR |title=Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score |journal=Mol. Med. |volume=16 |issue=7–8 |pages=247–53 |year=2010 |pmid=20379614 |pmc=2896464 |doi=10.2119/molmed.2009.00159 }}
- {{cite journal|author2-link=John R. Falck |vauthors=Wang H, Falck JR, Hall TM, Shears SB |title=Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding |journal=Nat. Chem. Biol. |volume=8 |issue=1 |pages=111–6 |year=2011 |pmid=22119861 |pmc=3923263 |doi=10.1038/nchembio.733 }}
- {{cite journal |vauthors=Weaver JD, Wang H, Shears SB |title=The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment |journal=Biosci. Rep. |volume=33 |issue=2 |pages=e00022 |year=2013 |pmid=23240582 |pmc=3564036 |doi=10.1042/BSR20120115 }}
- {{cite journal |vauthors=Yong ST, Nguyen HN, Choi JH, Bortner CD, Williams J, Pulloor NK, Krishnan MN, Shears SB |title=Identification of a functional nuclear translocation sequence in hPPIP5K2 |journal=BMC Cell Biol. |volume=16 |pages=17 |year=2015 |pmid=26084399 |pmc=4472268 |doi=10.1186/s12860-015-0063-7 |doi-access=free }}
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