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PPP1CA

{{Short description|Enzyme}}

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{{Infobox_gene}}

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the PPP1CA gene.

Function

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.{{cite web | title = Entrez Gene: PPP1CA protein phosphatase 1, catalytic subunit, alpha isoform| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5499}}

Interactive pathway map

{{NicotineDopaminergicActivity_WP1602|highlight=PPP1CA}}

Interactions

PPP1CA has been shown to interact with:

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  • AKAP11,{{cite journal | vauthors = Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A | title = A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta | journal = J. Biol. Chem. | volume = 277 | issue = 40 | pages = 36955–61 | date = October 2002 | pmid = 12147701 | doi = 10.1074/jbc.M206210200 | doi-access = free}}{{cite journal | vauthors = Schillace RV, Scott JD | title = Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220 | journal = Curr. Biol. | volume = 9 | issue = 6 | pages = 321–4 | date = March 1999 | pmid = 10209101 | doi = 10.1016/s0960-9822(99)80141-9| s2cid = 9188320 | doi-access = free | bibcode = 1999CBio....9..321S }}
  • BCL2-like 1,{{cite journal | vauthors = Ayllón V, Cayla X, García A, Fleischer A, Rebollo A | title = The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad | journal = Eur. J. Immunol. | volume = 32 | issue = 7 | pages = 1847–55 | date = July 2002 | pmid = 12115603 | doi = 10.1002/1521-4141(200207)32:7<1847::AID-IMMU1847>3.0.CO;2-7 | doi-access = free }}
  • BCL2L2,
  • BRCA1,{{cite journal | vauthors = Liu Y, Virshup DM, White RL, Hsu LC | title = Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha | journal = Cancer Res. | volume = 62 | issue = 22 | pages = 6357–61 | date = November 2002 | pmid = 12438214 }}
  • CDC5L,{{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = EMBO J. | volume = 19 | issue = 23 | pages = 6569–81 | date = December 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}
  • Host cell factor C1,{{cite journal | vauthors = Ajuh PM, Browne GJ, Hawkes NA, Cohen PT, Roberts SG, Lamond AI | title = Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex | journal = Nucleic Acids Res. | volume = 28 | issue = 3 | pages = 678–86 | date = February 2000 | pmid = 10637318 | pmc = 102561 | doi = 10.1093/nar/28.3.678}}
  • KvLQT1,{{cite journal | vauthors = Marx SO, Kurokawa J, Reiken S, Motoike H, D'Armiento J, Marks AR, Kass RS | title = Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel | journal = Science | volume = 295 | issue = 5554 | pages = 496–9 | date = January 2002 | pmid = 11799244 | doi = 10.1126/science.1066843 | bibcode = 2002Sci...295..496M | s2cid = 6153394 }}
  • LMTK2,{{cite journal | vauthors = Wang H, Brautigan DL | title = A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2 | journal = J. Biol. Chem. | volume = 277 | issue = 51 | pages = 49605–12 | date = December 2002 | pmid = 12393858 | doi = 10.1074/jbc.M209335200 | doi-access = free }}
  • PHACTR3,{{cite journal | vauthors = Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S | title = Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure | journal = J. Biol. Chem. | volume = 278 | issue = 46 | pages = 45611–9 | date = November 2003 | pmid = 12925532 | doi = 10.1074/jbc.M305227200 | doi-access = free }}
  • PPP1R15A,{{cite journal | vauthors = Hung WJ, Roberson RS, Taft J, Wu DY | title = Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions | journal = Mol. Cell. Biol. | volume = 23 | issue = 10 | pages = 3477–86 | date = May 2003 | pmid = 12724406 | pmc = 164759 | doi = 10.1128/mcb.23.10.3477-3486.2003}}{{cite journal | vauthors = Wu DY, Tkachuck DC, Roberson RS, Schubach WH | title = The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity | journal = J. Biol. Chem. | volume = 277 | issue = 31 | pages = 27706–15 | date = August 2002 | pmid = 12016208 | doi = 10.1074/jbc.M200955200 | doi-access = free }}{{cite journal | vauthors = Connor JH, Weiser DC, Li S, Hallenbeck JM, Shenolikar S | title = Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1 | journal = Mol. Cell. Biol. | volume = 21 | issue = 20 | pages = 6841–50 | date = October 2001 | pmid = 11564868 | pmc = 99861 | doi = 10.1128/MCB.21.20.6841-6850.2001 }}
  • PPP1R8,{{cite journal | vauthors = Jin Q, van Eynde A, Beullens M, Roy N, Thiel G, Stalmans W, Bollen M | title = The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor | journal = J. Biol. Chem. | volume = 278 | issue = 33 | pages = 30677–85 | date = August 2003 | pmid = 12788942 | doi = 10.1074/jbc.M302273200 | doi-access = free}}
  • PPP1R9B,{{cite journal | vauthors = Hsieh-Wilson LC, Allen PB, Watanabe T, Nairn AC, Greengard P | title = Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1 | journal = Biochemistry | volume = 38 | issue = 14 | pages = 4365–73 | date = April 1999 | pmid = 10194355 | doi = 10.1021/bi982900m }}
  • Protein kinase R,{{cite journal | vauthors = Tan SL, Tareen SU, Melville MW, Blakely CM, Katze MG | title = The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation | journal = J. Biol. Chem. | volume = 277 | issue = 39 | pages = 36109–17 | date = September 2002 | pmid = 12138106 | doi = 10.1074/jbc.M205109200 | doi-access = free }} and
  • SMARCB1.

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References

{{Reflist}}

Further reading

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  • {{cite journal | vauthors = Cohen PT | title = Protein phosphatase 1--targeted in many directions. | journal = J. Cell Sci. | volume = 115 | issue = Pt 2 | pages = 241–56 | year = 2002 | doi = 10.1242/jcs.115.2.241 | pmid = 11839776 }}
  • {{cite journal | vauthors = Barker HM, Jones TA, da Cruz e Silva EF, Spurr NK, Sheer D, Cohen PT | title = Localization of the gene encoding a type I protein phosphatase catalytic subunit to human chromosome band 11q13. | journal = Genomics | volume = 7 | issue = 2 | pages = 159–66 | year = 1990 | pmid = 2161401 | doi = 10.1016/0888-7543(90)90536-4 }}
  • {{cite journal | vauthors = Carrey EA, Campbell DG, Hardie DG | title = Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis. | journal = EMBO J. | volume = 4 | issue = 13B | pages = 3735–42 | year = 1986 | pmid = 4092695 | pmc = 554725 | doi = 10.1002/j.1460-2075.1985.tb04142.x}}
  • {{cite journal | vauthors = Saadat M, Mizuno Y, Kikuchi K, Yoshida MC | title = Comparative mapping of the gene encoding the catalytic subunit of protein phosphatase type 1 alpha (PPP1CA) to human, rat, and mouse chromosomes. | journal = Cytogenet. Cell Genet. | volume = 70 | issue = 1–2 | pages = 55–7 | year = 1995 | pmid = 7736790 | doi = 10.1159/000133991 }}
  • {{cite journal | vauthors = Durfee T, Becherer K, Chen PL, Yeh SH, Yang Y, Kilburn AE, Lee WH, Elledge SJ | title = The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit | journal = Genes Dev. | volume = 7 | issue = 4 | pages = 555–69 | year = 1993 | pmid = 8384581 | doi = 10.1101/gad.7.4.555 | doi-access = free }}
  • {{cite journal | vauthors = Song Q, Khanna KK, Lu H, Lavin MF | title = Cloning and characterization of a human protein phosphatase 1-encoding cDNA | journal = Gene | volume = 129 | issue = 2 | pages = 291–5 | year = 1993 | pmid = 8392016 | doi = 10.1016/0378-1119(93)90282-8 }}
  • {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1997 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
  • {{cite journal | vauthors = Kwon YG, Huang HB, Desdouits F, Girault JA, Greengard P, Nairn AC | title = Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 8 | pages = 3536–41 | year = 1997 | pmid = 9108011 | pmc = 20474 | doi = 10.1073/pnas.94.8.3536 | bibcode = 1997PNAS...94.3536K | doi-access = free }}
  • {{cite journal | vauthors = Colbran RJ, Bass MA, McNeill RB, Bollen M, Zhao S, Wadzinski BE, Strack S | title = Association of brain protein phosphatase 1 with cytoskeletal targeting/regulatory subunits | journal = J. Neurochem. | volume = 69 | issue = 3 | pages = 920–9 | year = 1997 | pmid = 9282913 | doi = 10.1046/j.1471-4159.1997.69030920.x | s2cid = 34789662 | doi-access = free }}
  • {{cite journal | vauthors = Allen PB, Kwon YG, Nairn AC, Greengard P | title = Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit | journal = J. Biol. Chem. | volume = 273 | issue = 7 | pages = 4089–95 | year = 1998 | pmid = 9461602 | doi = 10.1074/jbc.273.7.4089 | doi-access = free }}
  • {{cite journal |author4-link=Ernest Y. C. Lee | vauthors = Zhang J, Zhang L, Zhao S, Lee EY | title = Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1 | journal = Biochemistry | volume = 37 | issue = 47 | pages = 16728–34 | year = 1998 | pmid = 9843442 | doi = 10.1021/bi981169g }}
  • {{cite journal | vauthors = Neumann J, Maas R, Bokník P, Jones LR, Zimmermann N, Scholz H | title = Pharmacological characterization of protein phosphatase activities in preparations from failing human hearts | journal = J. Pharmacol. Exp. Ther. | volume = 289 | issue = 1 | pages = 188–93 | year = 1999 | pmid = 10087003 }}
  • {{cite journal | vauthors = Schillace RV, Scott JD | title = Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220 | journal = Curr. Biol. | volume = 9 | issue = 6 | pages = 321–4 | year = 1999 | pmid = 10209101 | doi = 10.1016/S0960-9822(99)80141-9 | s2cid = 9188320 | doi-access = free | bibcode = 1999CBio....9..321S }}
  • {{cite journal | vauthors = Takahashi M, Shibata H, Shimakawa M, Miyamoto M, Mukai H, Ono Y | title = Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus | journal = J. Biol. Chem. | volume = 274 | issue = 24 | pages = 17267–74 | year = 1999 | pmid = 10358086 | doi = 10.1074/jbc.274.24.17267 | doi-access = free }}
  • {{cite journal | vauthors = McAvoy T, Allen PB, Obaishi H, Nakanishi H, Takai Y, Greengard P, Nairn AC, Hemmings HC | title = Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation | journal = Biochemistry | volume = 38 | issue = 39 | pages = 12943–9 | year = 1999 | pmid = 10504266 | doi = 10.1021/bi991227d }}
  • {{cite journal | vauthors = Yoshida K, Watanabe M, Kato H, Dutta A, Sugano S | title = BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase 1 alpha through its intracellular domain | journal = FEBS Lett. | volume = 460 | issue = 1 | pages = 93–8 | year = 1999 | pmid = 10571067 | doi = 10.1016/S0014-5793(99)01309-5 | s2cid = 24377126 | doi-access = | bibcode = 1999FEBSL.460...93Y }}
  • {{cite journal | vauthors = Yang J, Hurley TD, DePaoli-Roach AA | title = Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif | journal = J. Biol. Chem. | volume = 275 | issue = 30 | pages = 22635–44 | year = 2000 | pmid = 10807923 | doi = 10.1074/jbc.M003082200 | doi-access = free }}
  • {{cite journal | vauthors = Ayllón V, Martínez-A C, García A, Cayla X, Rebollo A | title = Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis | journal = EMBO J. | volume = 19 | issue = 10 | pages = 2237–46 | year = 2000 | pmid = 10811615 | pmc = 384373 | doi = 10.1093/emboj/19.10.2237 }}
  • {{cite journal | vauthors = Boudrez A, Beullens M, Groenen P, Van Eynde A, Vulsteke V, Jagiello I, Murray M, Krainer AR, Stalmans W, Bollen M | title = NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry | journal = J. Biol. Chem. | volume = 275 | issue = 33 | pages = 25411–7 | year = 2000 | pmid = 10827081 | doi = 10.1074/jbc.M001676200 | doi-access = free }}
  • {{cite journal | vauthors = Helps NR, Luo X, Barker HM, Cohen PT | title = NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1 | journal = Biochem. J. | volume = 349 | issue = Pt 2 | pages = 509–18 | year = 2001 | pmid = 10880350 | pmc = 1221174 | doi = 10.1042/0264-6021:3490509 }}

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