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PPP2R2B

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an enzyme that in humans is encoded by the PPP2R2B gene.{{cite journal | vauthors = Mayer RE, Hendrix P, Cron P, Matthies R, Stone SR, Goris J, Merlevede W, Hofsteenge J, Hemmings BA | title = Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform | journal = Biochemistry | volume = 30 | issue = 15 | pages = 3589–97 |date=May 1991 | pmid = 1849734 | doi =10.1021/bi00229a001 }}{{cite journal | vauthors = Holmes SE, O'Hearn EE, McInnis MG, Gorelick-Feldman DA, Kleiderlein JJ, Callahan C, Kwak NG, Ingersoll-Ashworth RG, Sherr M, Sumner AJ, Sharp AH, Ananth U, Seltzer WK, Boss MA, Vieria-Saecker AM, Epplen JT, Riess O, Ross CA, Margolis RL | title = Expansion of a novel CAG trinucleotide repeat in the 5' region of PPP2R2B is associated with SCA12 | journal = Nat Genet | volume = 23 | issue = 4 | pages = 391–2 |date=Dec 1999 | pmid = 10581021 | doi = 10.1038/70493 | s2cid = 33491731 }}

The product of this gene belongs to the phosphatase 2regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in the 5' UTR of this gene may cause a rare form of autosomal dominant spinocerebellar ataxia 12.{{cite web | title = Entrez Gene: PPP2R2B protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5521}}

References

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Further reading

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  • {{cite journal | vauthors=Millward TA, Zolnierowicz S, Hemmings BA |title=Regulation of protein kinase cascades by protein phosphatase 2A. |journal=Trends Biochem. Sci. |volume=24 |issue= 5 |pages= 186–91 |year= 1999 |pmid= 10322434 |doi=10.1016/S0968-0004(99)01375-4 }}
  • {{cite journal | vauthors=Andersen JL, Planelles V |title=The role of Vpr in HIV-1 pathogenesis. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 43–51 |year= 2005 |pmid= 15638722 |doi=10.2174/1570162052772988 }}
  • {{cite journal | vauthors=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11 | pmc=554975 |doi-access=free }}
  • {{cite journal | vauthors=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143–9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279 |doi-access= free }}
  • {{cite journal | vauthors=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270–86 |year= 2005 |pmid= 15817944 }}
  • {{cite journal | vauthors=Schalling M, Hudson TJ, Buetow KH, Housman DE |title=Direct detection of novel expanded trinucleotide repeats in the human genome. |journal=Nat. Genet. |volume=4 |issue= 2 |pages= 135–9 |year= 1993 |pmid= 8348150 |doi= 10.1038/ng0693-135 |s2cid=13281635 }}
  • {{cite journal |vauthors=Tung HY, De Rocquigny H, Zhao LJ, etal |title=Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr. |journal=FEBS Lett. |volume=401 |issue= 2–3 |pages= 197–201 |year= 1997 |pmid= 9013886 |doi=10.1016/S0014-5793(96)01470-6 |s2cid=23293768 |doi-access=free }}
  • {{cite journal | vauthors=Ruediger R, Brewis N, Ohst K, Walter G |title=Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production |journal=Virology |volume=238 |issue= 2 |pages= 432–43 |year= 1998 |pmid= 9400615 |doi= 10.1006/viro.1997.8873 |doi-access= free }}
  • {{cite journal |vauthors=Strack S, Zaucha JA, Ebner FF, etal |title=Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits |journal=J. Comp. Neurol. |volume=392 |issue= 4 |pages= 515–27 |year= 1998 |pmid= 9514514 |doi=10.1002/(SICI)1096-9861(19980323)392:4<515::AID-CNE8>3.0.CO;2-3 |s2cid=20496320 }}
  • {{cite journal |vauthors=Fujigasaki H, Verma IC, Camuzat A, etal |title=SCA12 is a rare locus for autosomal dominant cerebellar ataxia: a study of an Indian family |journal=Ann. Neurol. |volume=49 |issue= 1 |pages= 117–21 |year= 2001 |pmid= 11198281 |doi=10.1002/1531-8249(200101)49:1<117::AID-ANA19>3.0.CO;2-G |s2cid=20499068 }}
  • {{cite journal |vauthors=Elder RT, Yu M, Chen M, etal |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25 |journal=Virology |volume=287 |issue= 2 |pages= 359–70 |year= 2001 |pmid= 11531413 |doi= 10.1006/viro.2001.1007 |doi-access= free }}
  • {{cite journal | vauthors=Guo CY, Brautigan DL, Larner JM |title=ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 4839–44 |year= 2002 |pmid= 11723136 |doi= 10.1074/jbc.M110092200 |doi-access= free}}
  • {{cite journal |vauthors=Bennin DA, Don AS, Brake T, etal |title=Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 27449–67 |year= 2002 |pmid= 11956189 |doi= 10.1074/jbc.M111693200 |doi-access= free }}
  • {{cite journal |vauthors=Okamoto K, Li H, Jensen MR, etal |title=Cyclin G recruits PP2A to dephosphorylate Mdm2 |journal=Mol. Cell |volume=9 |issue= 4 |pages= 761–71 |year= 2002 |pmid= 11983168 |doi=10.1016/S1097-2765(02)00504-X |doi-access=free }}
  • {{cite journal |vauthors=Marmorstein LY, McLaughlin PJ, Stanton JB, etal |title=Bestrophin interacts physically and functionally with protein phosphatase 2A |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 30591–7 |year= 2002 |pmid= 12058047 |doi= 10.1074/jbc.M204269200 |doi-access= free }}
  • {{cite journal | vauthors=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A |journal=EMBO J. |volume=21 |issue= 14 |pages= 3918 |year= 2002 |pmid= 12110603 |doi= 10.1093/emboj/cdf420 | pmc=126131 }}

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External links

  • [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=sca12 GeneReviews/NCBI/NIH/UW entry on Spinocerebellar Ataxia Type 12]

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