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PPP2R3A

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox gene}}

Serine/threonine-protein phosphatase 2A regulatory subunit B subunit alpha is an enzyme that in humans is encoded by the PPP2R3A gene.{{cite journal |vauthors=Hendrix P, Mayer-Jackel RE, Cron P, Goris J, Hofsteenge J, Merlevede W, Hemmings BA | title = Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing | journal = J Biol Chem | volume = 268 | issue = 20 | pages = 15267–76 |date=Aug 1993 | doi = 10.1016/S0021-9258(18)82465-6 | pmid = 8392071 | doi-access = free }}{{cite web | title = Entrez Gene: PPP2R3A protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5523}}

Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B family. The B family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B. Alternative splicing results in multiple transcript variants encoding different isoforms.{{cite web | title = Entrez Gene: PPP2R3A protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5523}}

Interactions

PPP2R3A has been shown to interact with CDC6{{cite journal |last=Davis |first=Anthony J |author2=Yan Zhen |author3=Martinez Bobbie |author4=Mumby Marc C |date=Jun 2008 |title=Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit |journal=J. Biol. Chem. |volume=283 |issue=23 |pages=16104–14 |location=United States |issn=0021-9258 |pmid=18397887 |doi=10.1074/jbc.M710313200 |pmc=2414307 |doi-access=free }} and PPP2R4.

References

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Further reading

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  • {{cite journal | author=Zolnierowicz S |title=Type 2A protein phosphatase, the complex regulator of numerous signaling pathways. |journal=Biochem. Pharmacol. |volume=60 |issue=8 |pages=1225–35 |year=2000 |pmid=11007961 |doi=10.1016/S0006-2952(00)00424-X }}
  • {{cite journal |vauthors=Andersen JL, Planelles V |title=The role of Vpr in HIV-1 pathogenesis. |journal=Curr. HIV Res. |volume=3 |issue=1 |pages=43–51 |year=2005 |pmid=15638722 |doi=10.2174/1570162052772988 }}
  • {{cite journal |vauthors=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |pages=11 |year=2006 |pmid=15725353 |doi=10.1186/1742-4690-2-11 |pmc=554975 |doi-access=free }}
  • {{cite journal |vauthors=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue=3 |pages=143–9 |year=2005 |pmid=15780175 |doi=10.1038/sj.cr.7290279 |doi-access=free }}
  • {{cite journal |vauthors=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue=4 |pages=270–86 |year=2005 |pmid=15817944 }}
  • {{cite journal |vauthors=Mayer RE, Hendrix P, Cron P, etal |title=Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform. |journal=Biochemistry |volume=30 |issue=15 |pages=3589–97 |year=1991 |pmid=1849734 |doi=10.1021/bi00229a001 }}
  • {{cite journal |vauthors=Tung HY, De Rocquigny H, Zhao LJ, etal |title=Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr. |journal=FEBS Lett. |volume=401 |issue=2–3 |pages=197–201 |year=1997 |pmid=9013886 |doi=10.1016/S0014-5793(96)01470-6 |s2cid=23293768 |doi-access=free }}
  • {{cite journal |vauthors=Ruediger R, Brewis N, Ohst K, Walter G |title=Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production |journal=Virology |volume=238 |issue=2 |pages=432–43 |year=1998 |pmid=9400615 |doi=10.1006/viro.1997.8873 |doi-access=free }}
  • {{cite journal |vauthors=Ruediger R, Fields K, Walter G |title=Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens |journal=J. Virol. |volume=73 |issue=1 |pages=839–42 |year=1999 |pmid=9847399 |doi=10.1128/JVI.73.1.839-842.1999 |pmc=103900 }}
  • {{cite journal |vauthors=Voorhoeve PM, Hijmans EM, Bernards R |title=Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein |journal=Oncogene |volume=18 |issue=2 |pages=515–24 |year=1999 |pmid=9927208 |doi=10.1038/sj.onc.1202316 |doi-access=free }}
  • {{cite journal |vauthors=Takahashi M, Shibata H, Shimakawa M, etal |title=Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus |journal=J. Biol. Chem. |volume=274 |issue=24 |pages=17267–74 |year=1999 |pmid=10358086 |doi=10.1074/jbc.274.24.17267 |doi-access=free }}
  • {{cite journal |vauthors=Yan Z, Fedorov SA, Mumby MC, Williams RS |title=PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells |journal=Mol. Cell. Biol. |volume=20 |issue=3 |pages=1021–9 |year=2000 |pmid=10629059 |doi=10.1128/MCB.20.3.1021-1029.2000 |pmc=85219 }}
  • {{cite journal |vauthors=Lubert EJ, Hong Y, Sarge KD |title=Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: evidence for a heterotrimeric form of protein phosphatase 5 |journal=J. Biol. Chem. |volume=276 |issue=42 |pages=38582–7 |year=2001 |pmid=11504734 |doi=10.1074/jbc.M106906200 |doi-access=free }}
  • {{cite journal |vauthors=Elder RT, Yu M, Chen M, etal |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25 |journal=Virology |volume=287 |issue=2 |pages=359–70 |year=2001 |pmid=11531413 |doi=10.1006/viro.2001.1007 |doi-access=free }}
  • {{cite journal |vauthors=Dintilhac A, Bernués J |title=HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences |journal=J. Biol. Chem. |volume=277 |issue=9 |pages=7021–8 |year=2002 |pmid=11748221 |doi=10.1074/jbc.M108417200 |s2cid=39560486 |url=https://digital.csic.es/bitstream/10261/112516/4/jbc.M108417200.full.pdf |doi-access=free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue=26 |pages=16899–903 |year=2003 |pmid=12477932 |doi=10.1073/pnas.242603899 |pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}

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