PPP2R5A

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily.{{cite web | title = Entrez Gene: PPP2R5A protein phosphatase 2, regulatory subunit B', alpha isoform| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5525}}

PPP2R5A has been shown to interact with:

• AXIN1,{{cite journal | vauthors = Yamamoto H, Hinoi T, Michiue T, Fukui A, Usui H, Janssens V, Van Hoof C, Goris J, Asashima M, Kikuchi A | title = Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A | journal = The Journal of Biological Chemistry | volume = 276 | issue = 29 | pages = 26875–82 | date = Jul 2001 | pmid = 11297546 | doi = 10.1074/jbc.M100443200 | doi-access = free }}
• CTLA-4,{{cite journal | vauthors = Baroja ML, Vijayakrishnan L, Bettelli E, Darlington PJ, Chau TA, Ling V, Collins M, Carreno BM, Madrenas J, Kuchroo VK | title = Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A | journal = Journal of Immunology | volume = 168 | issue = 10 | pages = 5070–8 | date = May 2002 | pmid = 11994459 | doi = 10.4049/jimmunol.168.10.5070| doi-access = free }}
• PPP2CA,
• PPP2R1A,
• PPP2R1B,{{cite journal | vauthors = Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC | title = A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein | journal = Molecular & Cellular Proteomics | volume = 8 | issue = 1 | pages = 157–71 | date = Jan 2009 | pmid = 18782753 | pmc = 2621004 | doi = 10.1074/mcp.M800266-MCP200 | doi-access = free }}{{cite journal | vauthors = Zhou J, Pham HT, Ruediger R, Walter G | title = Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution | journal = The Biochemical Journal | volume = 369 | issue = Pt 2 | pages = 387–98 | date = Jan 2003 | pmid = 12370081 | pmc = 1223084 | doi = 10.1042/BJ20021244 }}{{cite journal | vauthors = McCright B, Rivers AM, Audlin S, Virshup DM | title = The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm | journal = The Journal of Biological Chemistry | volume = 271 | issue = 36 | pages = 22081–9 | date = Sep 1996 | pmid = 8703017 | doi = 10.1074/jbc.271.36.22081| doi-access = free }}{{cite journal | vauthors = Strack S, Ruediger R, Walter G, Dagda RK, Barwacz CA, Cribbs JT | title = Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits | journal = The Journal of Biological Chemistry | volume = 277 | issue = 23 | pages = 20750–5 | date = Jun 2002 | pmid = 11929880 | doi = 10.1074/jbc.M202992200| doi-access = free }} and
• PPP2R5C

{{Reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = Andersen JL, Planelles V | title = The role of Vpr in HIV-1 pathogenesis | journal = Current HIV Research | volume = 3 | issue = 1 | pages = 43–51 | date = Jan 2005 | pmid = 15638722 | doi = 10.2174/1570162052772988 }}
• {{cite journal | vauthors = Le Rouzic E, Benichou S | title = The Vpr protein from HIV-1: distinct roles along the viral life cycle | journal = Retrovirology | volume = 2 | pages = 11 | year = 2006 | pmid = 15725353 | pmc = 554975 | doi = 10.1186/1742-4690-2-11 | doi-access = free }}
• {{cite journal | vauthors = Zhao RY, Elder RT | title = Viral infections and cell cycle G2/M regulation | journal = Cell Research | volume = 15 | issue = 3 | pages = 143–9 | date = Mar 2005 | pmid = 15780175 | doi = 10.1038/sj.cr.7290279 | doi-access = free }}
• {{cite journal | vauthors = Zhao RY, Bukrinsky M, Elder RT | title = HIV-1 viral protein R (Vpr) & host cellular responses | journal = The Indian Journal of Medical Research | volume = 121 | issue = 4 | pages = 270–86 | date = Apr 2005 | pmid = 15817944 }}
• {{cite journal | vauthors = Zolnierowicz S, Van Hoof C, Andjelković N, Cron P, Stevens I, Merlevede W, Goris J, Hemmings BA | title = The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits | journal = The Biochemical Journal | volume = 317 | issue = 1 | pages = 187–94 | date = Jul 1996 | pmid = 8694763 | pmc = 1217462 | doi = 10.1042/bj3170187}}
• {{cite journal | vauthors = Fuhrer DK, Yang YC | title = Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11 | journal = Biochemical and Biophysical Research Communications | volume = 224 | issue = 2 | pages = 289–96 | date = Jul 1996 | pmid = 8702385 | doi = 10.1006/bbrc.1996.1023 }}
• {{cite journal | vauthors = McCright B, Rivers AM, Audlin S, Virshup DM | title = The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm | journal = The Journal of Biological Chemistry | volume = 271 | issue = 36 | pages = 22081–9 | date = Sep 1996 | pmid = 8703017 | doi = 10.1074/jbc.271.36.22081 | doi-access = free }}
• {{cite journal | vauthors = McCright B, Brothman AR, Virshup DM | title = Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12 | journal = Genomics | volume = 36 | issue = 1 | pages = 168–70 | date = Aug 1996 | pmid = 8812429 | doi = 10.1006/geno.1996.0438 }}
• {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
• {{cite journal | vauthors = Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R | title = Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr | journal = FEBS Letters | volume = 401 | issue = 2–3 | pages = 197–201 | date = Jan 1997 | pmid = 9013886 | doi = 10.1016/S0014-5793(96)01470-6 | doi-access = free }}
• {{cite journal | vauthors = Ruediger R, Brewis N, Ohst K, Walter G | title = Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production | journal = Virology | volume = 238 | issue = 2 | pages = 432–43 | date = Nov 1997 | pmid = 9400615 | doi = 10.1006/viro.1997.8873 | doi-access = free }}
• {{cite journal | vauthors = Ruediger R, Fields K, Walter G | title = Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens | journal = Journal of Virology | volume = 73 | issue = 1 | pages = 839–42 | date = Jan 1999 | doi = 10.1128/JVI.73.1.839-842.1999 | pmid = 9847399 | pmc = 103900 }}
• {{cite journal | vauthors = Seeling JM, Miller JR, Gil R, Moon RT, White R, Virshup DM | title = Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A | journal = Science | volume = 283 | issue = 5410 | pages = 2089–91 | date = Mar 1999 | pmid = 10092233 | doi = 10.1126/science.283.5410.2089 }}
• {{cite journal | vauthors = Xu Z, Williams BR | title = The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR | journal = Molecular and Cellular Biology | volume = 20 | issue = 14 | pages = 5285–99 | date = Jul 2000 | pmid = 10866685 | pmc = 85978 | doi = 10.1128/MCB.20.14.5285-5299.2000 }}
• {{cite journal | vauthors = Fleming I, Fisslthaler B, Dimmeler S, Kemp BE, Busse R | title = Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity | journal = Circulation Research | volume = 88 | issue = 11 | pages = E68–75 | date = Jun 2001 | pmid = 11397791 | doi = 10.1161/hh1101.092677 | s2cid = 86348254 | doi-access = }}
• {{cite journal | vauthors = Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y | title = HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25 | journal = Virology | volume = 287 | issue = 2 | pages = 359–70 | date = Sep 2001 | pmid = 11531413 | doi = 10.1006/viro.2001.1007 | doi-access = free }}
• {{cite journal | vauthors = Galea MA, Eleftheriou A, Henderson BR | title = ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A | journal = The Journal of Biological Chemistry | volume = 276 | issue = 49 | pages = 45833–9 | date = Dec 2001 | pmid = 11585828 | doi = 10.1074/jbc.M107149200 | doi-access = free }}
• {{cite journal | vauthors = Li X, Virshup DM | title = Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A | journal = European Journal of Biochemistry | volume = 269 | issue = 2 | pages = 546–52 | date = Jan 2002 | pmid = 11856313 | doi = 10.1046/j.0014-2956.2001.02680.x | doi-access = free }}

{{refend}}

{{Gene-1-stub}}