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PPP3R1

{{Short description|Protein-coding gene in the species Homo sapiens}}

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{{Infobox_gene}}

Calcineurin subunit B type 1 also known as protein phosphatase 2B regulatory subunit 1 is a protein that in humans is encoded by the PPP3R1 gene.{{cite journal | vauthors = Wang MG, Yi H, Guerini D, Klee CB, McBride OW | title = Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively | journal = Cytogenet Cell Genet | volume = 72 | issue = 2–3 | pages = 236–41 |date=Jan 1997 | pmid = 8978785 | doi =10.1159/000134198 | url = https://zenodo.org/record/1235418 }}{{cite journal | vauthors = Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB | title = Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase | journal = DNA | volume = 8 | issue = 9 | pages = 675–82 |date=Mar 1990 | pmid = 2558868 | doi = 10.1089/dna.1.1989.8.675}}{{cite web | title = Entrez Gene: PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5534}}

Clinical significance

The presence of a single nucleotide polymorphism rs1868402 in the PPP3R1 gene is strongly correlated with rapid progress of Alzheimer's disease.{{cite journal |vauthors=Cruchaga C, Kauwe JS, Mayo K, Spiegel N, Bertelsen S, etal | editor1-last = Myers | editor1-first = Amanda J. | title = SNPs Associated with Cerebrospinal Fluid Phospho-Tau Levels Influence Rate of Decline in Alzheimer's Disease | journal = PLOS Genet | year = 2010 | volume = 6 | pmid = 20862329 | issue = 9 | pmc = 2940763 | pages = e1001101|doi=10.1371/journal.pgen.1001101 | doi-access = free }}

References

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Further reading

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  • {{cite journal | vauthors=Kawamura A, Su MS |title=Interaction of FKBP12-FK506 with calcineurin A at the B subunit-binding domain. |journal=J. Biol. Chem. |volume=270 |issue= 26 |pages= 15463–6 |year= 1995 |pmid= 7541044 |doi=10.1074/jbc.270.26.15463 |doi-access=free }}
  • {{cite journal |vauthors=Kissinger CR, Parge HE, Knighton DR, etal |title=Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. |journal=Nature |volume=378 |issue= 6557 |pages= 641–4 |year= 1996 |pmid= 8524402 |doi= 10.1038/378641a0 |bibcode=1995Natur.378..641K |s2cid=4337105 }}
  • {{cite journal | vauthors=Feng B, Stemmer PM |title=Interactions of calcineurin A, calcineurin B, and Ca2+. |journal=Biochemistry |volume=38 |issue= 38 |pages= 12481–9 |year= 1999 |pmid= 10493818 |doi=10.1021/bi990492w }}
  • {{cite journal | vauthors=Stratakis CA, Taymans SE |title=Structure of the gene coding for calcineurin B (PPP3R1) and mapping to D2S358-D2S1778 (chromosomal region 2p15). |journal=DNA Seq. |volume=9 |issue= 4 |pages= 227–30 |year= 1999 |pmid= 10520753 |doi=10.3109/10425179809105209 |url=https://zenodo.org/record/1235831 }}
  • {{cite journal |vauthors=Nishio H, Matsui K, Tsuji H, etal |title=Immunolocalization of calcineurin and FKBP12, the FK506-binding protein, in Hassall's corpuscles of human thymus and epidermis. |journal=Histochem. Cell Biol. |volume=114 |issue= 1 |pages= 9–14 |year= 2000 |pmid= 10959817 |doi= 10.1007/s004180000168 |s2cid=21530150 }}
  • {{cite journal |vauthors=Sokal I, Li N, Verlinde CL, etal |title=Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1). |journal=Biochim. Biophys. Acta |volume=1498 |issue= 2–3 |pages= 233–51 |year= 2001 |pmid= 11108966 |doi= 10.1016/S0167-4889(00)00099-9|doi-access=free }}
  • {{cite journal |vauthors=Graef IA, Chen F, Chen L, etal |title=Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. |journal=Cell |volume=105 |issue= 7 |pages= 863–75 |year= 2001 |pmid= 11439183 |doi=10.1016/S0092-8674(01)00396-8 |s2cid=5278706 |doi-access=free }}
  • {{cite journal |vauthors=Al-Daraji WI, Grant KR, Ryan K, etal |title=Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A. |journal=J. Invest. Dermatol. |volume=118 |issue= 5 |pages= 779–88 |year= 2002 |pmid= 11982754 |doi= 10.1046/j.1523-1747.2002.01709.x |doi-access= free }}
  • {{cite journal |vauthors=Huai Q, Kim HY, Liu Y, etal |title=Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 19 |pages= 12037–42 |year= 2002 |pmid= 12218175 |doi= 10.1073/pnas.192206699 | pmc=129394 |bibcode=2002PNAS...9912037H |doi-access=free }}
  • {{cite journal | vauthors=Jin L, Harrison SC |title=Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 21 |pages= 13522–6 |year= 2002 |pmid= 12357034 |doi= 10.1073/pnas.212504399 | pmc=129706 |bibcode=2002PNAS...9913522J |doi-access=free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | vauthors=Bennasser Y, Badou A, Tkaczuk J, Bahraoui E |title=Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. |journal=Virology |volume=303 |issue= 1 |pages= 174–80 |year= 2003 |pmid= 12482669 |doi=10.1006/viro.2002.1676 |doi-access=free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Bittinger MA, McWhinnie E, Meltzer J, etal |title=Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. |journal=Curr. Biol. |volume=14 |issue= 23 |pages= 2156–61 |year= 2005 |pmid= 15589160 |doi= 10.1016/j.cub.2004.11.002 |s2cid=5934014 |doi-access=free }}
  • {{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |bibcode=2005Natur.434..724H |doi-access= free }}
  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
  • {{cite journal | vauthors=Winslow MM, Gallo EM, Neilson JR, Crabtree GR |title=The calcineurin phosphatase complex modulates immunogenic B cell responses. |journal=Immunity |volume=24 |issue= 2 |pages= 141–52 |year= 2006 |pmid= 16473827 |doi= 10.1016/j.immuni.2005.12.013 |doi-access= free }}
  • {{cite journal |vauthors=Liu Q, Wilkins BJ, Lee YJ, etal |title=Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. |journal=Mol. Cell. Biol. |volume=26 |issue= 10 |pages= 3785–97 |year= 2006 |pmid= 16648474 |doi= 10.1128/MCB.26.10.3785-3797.2006 | pmc=1489013 }}

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Category:EF-hand-containing proteins