PPRC1
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 is a protein that in humans is encoded by the PPRC1 gene.{{cite journal |vauthors=Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 1 | pages = 31–9 |date=Aug 1998 | pmid = 9628581 | doi =10.1093/dnares/5.1.31 | doi-access = free }}{{cite journal |vauthors=Andersson U, Scarpulla RC | title = PGC-1-Related Coactivator, a Novel, Serum-Inducible Coactivator of Nuclear Respiratory Factor 1-Dependent Transcription in Mammalian Cells | journal = Mol Cell Biol | volume = 21 | issue = 11 | pages = 3738–49 |date=May 2001 | pmid = 11340167 | pmc = 87014 | doi = 10.1128/MCB.21.11.3738-3749.2001 }}{{cite web | title = Entrez Gene: PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23082}}
The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPARGC1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals.
Interactions
PPRC1 has been shown to interact with USF2.{{cite journal |last=Moore |first=Meredith L |author2=Park Edwards A |author3=McMillin Jeanie B |date=May 2003 |title=Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1 |journal=J. Biol. Chem. |volume=278 |issue=19 |pages=17263–8 |location = United States| issn = 0021-9258| pmid = 12611894 |doi = 10.1074/jbc.M210486200 |doi-access=free }}
References
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Further reading
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- {{cite journal |vauthors=Finck BN, Kelly DP |title=PGC-1 coactivators: inducible regulators of energy metabolism in health and disease |journal=J. Clin. Invest. |volume=116 |issue= 3 |pages= 615–22 |year= 2006 |pmid= 16511594 |doi= 10.1172/JCI27794 | pmc=1386111 }}
- {{cite journal | author=Yamagata K |title=Bile acid represses the peroxisome proliferator-activated receptor-gamma coactivator-1 promoter activity in a small heterodimer partner-dependent manner |journal=Int. J. Mol. Med. |volume=19 |issue= 5 |pages= 751–6 |year= 2007 |pmid= 17390079 |doi= 10.3892/ijmm.19.5.751|name-list-style=vanc| author2=Yoshimochi K | author3=Daitoku H | display-authors=3 | last4=Hirota | first4=K | last5=Fukamizu | first5=A |doi-access=free}}
- {{cite journal |vauthors=Srivastava S, Barrett JN, Moraes CT |title=PGC-1α/β upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations |journal=Hum. Mol. Genet. |volume=16 |issue= 8 |pages= 993–1005 |year= 2007 |pmid= 17341490 |doi= 10.1093/hmg/ddm045 | pmc=2652746 }}
- {{cite journal |vauthors=Gleyzer N, Vercauteren K, Scarpulla RC |title=Control of Mitochondrial Transcription Specificity Factors (TFB1M and TFB2M) by Nuclear Respiratory Factors (NRF-1 and NRF-2) and PGC-1 Family Coactivators |journal=Mol. Cell. Biol. |volume=25 |issue= 4 |pages= 1354–66 |year= 2005 |pmid= 15684387 |doi= 10.1128/MCB.25.4.1354-1366.2005 | pmc=548005 }}
- {{cite journal | author=Yamamoto T |title=SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12027–35 |year= 2004 |pmid= 14722127 |doi= 10.1074/jbc.M310333200 |name-list-style=vanc| author2=Shimano H | author3=Nakagawa Y | display-authors=3 | last4=Ide | first4=T | last5=Yahagi | first5=N | last6=Matsuzaka | first6=T | last7=Nakakuki | first7=M | last8=Takahashi | first8=A | last9=Suzuki | first9=H | doi-access=free }}
- {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
- {{cite journal | author=Savagner F |title=PGC-1-related coactivator and targets are upregulated in thyroid oncocytoma |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 3 |pages= 779–84 |year= 2003 |pmid= 14550271 |doi=10.1016/j.bbrc.2003.09.076 |name-list-style=vanc| author2=Mirebeau D | author3=Jacques C | display-authors=3 | last4=Guyetant | first4=Serge | last5=Morgan | first5=Catherine | last6=Franc | first6=Brigitte | last7=Reynier | first7=Pascal | last8=Malthièry | first8=Yves }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M|doi-access=free }}
- {{cite journal | author=Scarpulla RC |title=Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells |journal=Gene |volume=286 |issue= 1 |pages= 81–9 |year= 2002 |pmid= 11943463 |doi=10.1016/S0378-1119(01)00809-5 }}
- {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
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