PPT2

This gene encodes a member of the palmitoyl protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins.

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• {{cite journal |vauthors=Gupta P, Soyombo AA, Atashband A|display-authors=etal |title=Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 24 |pages= 13566–71 |year= 2001 |pmid= 11717424 |pmc=61081 |doi= 10.1073/pnas.251485198 |bibcode=2001PNAS...9813566G |doi-access=free }}
• {{cite journal |vauthors=Aguado B, Campbell RD |title=Characterization of a human MHC class III region gene product with S-thioesterase activity |journal=Biochem. J. |volume=341 ( Pt 3) |issue= Pt 3|pages= 679–89 |year= 1999 |pmid= 10417332 |pmc=1220406 |doi= 10.1042/bj3410679}}
• {{cite journal |vauthors=Simpson JC, Wellenreuther R, Poustka A|display-authors=etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2000 |pmid= 11256614 |pmc=1083732 |doi= 10.1093/embo-reports/kvd058 }}
• {{cite journal |vauthors=Hancock DB, Eijgelsheim M, Wilk JB|display-authors=etal |title=Meta-analyses of genome-wide association studies identify multiple novel loci associated with pulmonary function |journal=Nat. Genet. |volume=42 |issue= 1 |pages= 45–52 |year= 2010 |pmid= 20010835 |pmc=2832852 |doi= 10.1038/ng.500 }}
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• {{cite journal |vauthors=Calero G, Gupta P, Nonato MC |display-authors=etal |title=The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2 |journal=J. Biol. Chem. |volume=278 |issue= 39 |pages= 37957–64 |year= 2003 |pmid= 12855696 |doi= 10.1074/jbc.M301225200 |doi-access=free }}
• {{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK |display-authors=etal |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |bibcode=2003Natur.425..805M |doi-access=free }}
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• {{cite journal |vauthors=McKinnon E, Morahan G, Nolan D |display-authors=etal |title=Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach |journal=Diabetes Obes Metab |volume=11 |issue= Suppl 1|pages= 92–100 |year= 2009 |pmid= 19143821 |pmc=2755510 |doi= 10.1111/j.1463-1326.2008.01009.x }}
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{{NLM content}}

{{Thioesterases}}

{{Enzymes}}

{{Portal bar|Biology|border=no}}

Category:EC 3.1.2

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