PRB1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Basic salivary proline-rich protein 1 is a protein that in humans is encoded by the PRB1 gene.{{cite journal | vauthors = Azen EA, Latreille P, Niece RL | title = PRBI gene variants coding for length and null polymorphisms among human salivary Ps, PmF, PmS, and Pe proline-rich proteins (PRPs) | journal = Am J Hum Genet | volume = 53 | issue = 1 | pages = 264–78 |date=Jul 1993 | pmid = 8317492 | pmc = 1682219 }}{{cite web | title = Entrez Gene: PRB1 proline-rich protein BstNI subfamily 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5542}}
The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region. Alternatively spliced transcript variants encoding distinct isoforms have been described.
References
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Further reading
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- {{cite book | vauthors=Azen EA, Maeda N |title=Advances in Human Genetics 1 |chapter=Molecular Genetics of Human Salivary Proteins and Their Polymorphisms |volume=17 |pages= 141–99 |year= 1988 |pmid= 3055850 |doi= 10.1007/978-1-4613-0987-1_5|isbn=978-1-4612-8279-2 }}
- {{cite journal | author=Bennick A |title=Salivary proline-rich proteins |journal=Mol. Cell. Biochem. |volume=45 |issue= 2 |pages= 83–99 |year= 1982 |pmid= 6810092 |doi=10.1007/BF00223503 |s2cid=31373141 }}
- {{cite journal | vauthors=Ikemoto S, Minaguchi K, Suzuki K, Tomita K |title=New Genetic marker in human parotid saliva (pm) |journal=Science |volume=197 |issue= 4301 |pages= 378–9 |year= 1977 |pmid= 877561 |doi=10.1126/science.877561 |bibcode=1977Sci...197..378I }}
- {{cite journal | vauthors=Castle AM, Stahl LE, Castle JD |title=A 13-amino acid n-terminal domain of a basic proline-rich protein is necessary for storage in secretory granules and facilitates exit from the endoplasmic reticulum |journal=J. Biol. Chem. |volume=267 |issue= 18 |pages= 13093–100 |year= 1992 |doi=10.1016/S0021-9258(18)42385-X |pmid= 1618808 |doi-access=free }}
- {{cite journal | vauthors=Lyons KM, Stein JH, Smithies O |title=Length Polymorphisms in Human Proline-Rich Protein Genes Generated by Intragenic Unequal Crossing over |journal=Genetics |volume=120 |issue= 1 |pages= 267–78 |year= 1989 |doi=10.1093/genetics/120.1.267 |pmid= 2851479 | pmc=1203497 }}
- {{cite journal | vauthors=Maeda N, Kim HS, Azen EA, Smithies O |title=Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system |journal=J. Biol. Chem. |volume=260 |issue= 20 |pages= 11123–30 |year= 1985 |doi=10.1016/S0021-9258(17)39156-1 |pmid= 2993301 |doi-access=free }}
- {{cite journal | vauthors=Kauffman D, Hofmann T, Bennick A, Keller P |title=Basic proline-rich proteins from human parotid saliva: complete covalent structures of proteins IB-1 and IB-6 |journal=Biochemistry |volume=25 |issue= 9 |pages= 2387–92 |year= 1986 |pmid= 3521730 |doi=10.1021/bi00357a013 }}
- {{cite journal |vauthors=Azen E, Lyons KM, McGonigal T, etal |title=Clones from the human gene complex coding for salivary proline-rich proteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 17 |pages= 5561–5 |year= 1984 |pmid= 6089212 |doi=10.1073/pnas.81.17.5561 | pmc=391746 |bibcode=1984PNAS...81.5561A |doi-access=free }}
- {{cite journal | vauthors=Saitoh E, Isemura S, Sanada K |title=Further fractionation of basic proline-rich peptides from human parotid saliva and complete amino acid sequence of basic proline-rich peptide P-H |journal=J. Biochem. |volume=94 |issue= 6 |pages= 1991–9 |year= 1984 |pmid= 6671974 |doi= 10.1093/oxfordjournals.jbchem.a134553}}
- {{cite journal | vauthors=Kauffman D, Wong R, Bennick A, Keller P |title=Basic proline-rich proteins from human parotid saliva: complete covalent structure of protein IB-9 and partial structure of protein IB-6, members of a polymorphic pair |journal=Biochemistry |volume=21 |issue= 25 |pages= 6558–62 |year= 1983 |pmid= 6924859 |doi=10.1021/bi00268a036 }}
- {{cite journal | vauthors=Isemura S, Saitoh E, Sanada K |title=Fractionation and characterization of basic proline-rich peptides of human parotid saliva and the amino acid sequence of proline-rich peptide P-E |journal=J. Biochem. |volume=91 |issue= 6 |pages= 2067–75 |year= 1982 |pmid= 7118863 |doi= 10.1093/oxfordjournals.jbchem.a133900}}
- {{cite journal |vauthors=Kim HS, Lyons KM, Saitoh E, etal |title=The structure and evolution of the human salivary proline-rich protein gene family |journal=Mamm. Genome |volume=4 |issue= 1 |pages= 3–14 |year= 1993 |pmid= 8422499 |doi=10.1007/BF00364656 |s2cid=24058984 }}
- {{cite journal | vauthors=Castle AM, Castle JD |title=Enhanced Glycosylation and Sulfation of Secretory Proteoglycans Is Coupled to the Expression of a Basic Secretory Protein |journal=Mol. Biol. Cell |volume=9 |issue= 3 |pages= 575–83 |year= 1998 |pmid= 9487127 |doi= 10.1091/mbc.9.3.575| pmc=25286 }}
- {{cite journal |vauthors=Harrington JJ, Sherf B, Rundlett S, etal |title=Creation of genome-wide protein expression libraries using random activation of gene expression |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440–5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107 |s2cid=25064683 }}
- {{cite journal | vauthors=Chan M, Bennick A |title=Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases |journal=Eur. J. Biochem. |volume=268 |issue= 12 |pages= 3423–31 |year= 2001 |pmid= 11422372 |doi=10.1046/j.1432-1327.2001.02241.x |doi-access=free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
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Category:Salivary proline-rich proteins
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