PRB3
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Basic salivary proline-rich protein 3 is a protein that in humans is encoded by the PRB3 gene.{{cite journal | vauthors = Gillece-Castro BL, Prakobphol A, Burlingame AL, Leffler H, Fisher SJ | title = Structure and bacterial receptor activity of a human salivary proline-rich glycoprotein | journal = J Biol Chem | volume = 266 | issue = 26 | pages = 17358–68 |date=Oct 1991 | doi = 10.1016/S0021-9258(19)47381-X | pmid = 1894623 | doi-access = free }}{{cite web | title = Entrez Gene: PRB3 proline-rich protein BstNI subfamily 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5544}}
The protein encoded by this gene is a proline-rich salivary protein. It is a major constituent of parotid saliva. This protein is proposed to act as a bacterial receptor. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region.
References
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Further reading
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- {{cite book | vauthors=Azen EA, Maeda N |title=Advances in Human Genetics 17 |chapter=Molecular Genetics of Human Salivary Proteins and Their Polymorphisms |pages= 141–99 |year= 1988 |pmid= 3055850 |doi= 10.1007/978-1-4613-0987-1_5|isbn=978-1-4612-8279-2 }}
- {{cite journal | vauthors=Azen EA, Minaguchi K, Latreille P, Kim HS |title=Alleles at the PRB3 locus coding for a disulfide-bonded human salivary proline-rich glycoprotein (Gl 8) and a null in an Ashkenazi Jew. |journal=Am. J. Hum. Genet. |volume=47 |issue= 4 |pages= 686–97 |year= 1990 |pmid= 2171329 | pmc=1683781 }}
- {{cite journal | vauthors=Lyons KM, Stein JH, Smithies O |title=Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over. |journal=Genetics |volume=120 |issue= 1 |pages= 267–78 |year= 1989 |doi=10.1093/genetics/120.1.267 |pmid= 2851479 | pmc=1203497 }}
- {{cite journal | vauthors=Maeda N, Kim HS, Azen EA, Smithies O |title=Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system. |journal=J. Biol. Chem. |volume=260 |issue= 20 |pages= 11123–30 |year= 1985 |doi=10.1016/S0021-9258(17)39156-1 |pmid= 2993301 |doi-access=free }}
- {{cite journal |vauthors=Adams MD, Kerlavage AR, Fleischmann RD, etal |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |url=http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf }}
- {{cite journal | vauthors=Azen E, Prakobphol A, Fisher SJ |title=PRB3 null mutations result in absence of the proline-rich glycoprotein Gl and abolish Fusobacterium nucleatum interactions with saliva in vitro. |journal=Infect. Immun. |volume=61 |issue= 10 |pages= 4434–9 |year= 1993 |pmid= 8406834 |doi= 10.1128/IAI.61.10.4434-4439.1993| pmc=281176 }}
- {{cite journal |vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S, etal |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi= 10.1073/pnas.97.7.3491| pmc=16267 |bibcode=2000PNAS...97.3491D |doi-access=free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
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