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PRB4

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Basic salivary proline-rich protein 4 is a protein that in humans is encoded by the PRB4 gene.{{cite web | title = Entrez Gene: PRB4 proline-rich protein BstNI subfamily 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5545}}

The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region.

PRB4 is post-translationally cleaved into three different mature peptides:

  • Protein N1
  • Glycosylated protein A
  • Peptide P-D (also known as proline-rich peptide IB-5)

References

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Further reading

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  • {{cite book | vauthors=Azen EA, Maeda N |title=Advances in Human Genetics 1 |chapter=Molecular Genetics of Human Salivary Proteins and Their Polymorphisms |volume=17 |pages= 141–199 |year= 1988 |pmid= 3055850 |doi= 10.1007/978-1-4613-0987-1_5|isbn=978-1-4612-8279-2 }}
  • {{cite journal | author=Bennick A |title=Salivary proline-rich proteins |journal=Mol. Cell. Biochem. |volume=45 |issue= 2 |pages= 83–99 |year= 1982 |pmid= 6810092 |doi=10.1007/BF00223503 |s2cid=31373141 }}
  • {{cite journal | vauthors=Lyons KM, Stein JH, Smithies O |title=Length Polymorphisms in Human Proline-Rich Protein Genes Generated by Intragenic Unequal Crossing over |journal=Genetics |volume=120 |issue= 1 |pages= 267–78 |year= 1989 |doi=10.1093/genetics/120.1.267 |pmid= 2851479 | pmc=1203497 }}
  • {{cite journal | vauthors=Maeda N, Kim HS, Azen EA, Smithies O |title=Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system |journal=J. Biol. Chem. |volume=260 |issue= 20 |pages= 11123–30 |year= 1985 |doi=10.1016/S0021-9258(17)39156-1 |pmid= 2993301 |doi-access=free }}
  • {{cite journal | vauthors=Lyons KM, Azen EA, Goodman PA, Smithies O |title=Many Protein Products from a Few Loci: Assignment of Human Salivary Proline-Rich Proteins to Specific Loci |journal=Genetics |volume=120 |issue= 1 |pages= 255–65 |year= 1989 |doi=10.1093/genetics/120.1.255 |pmid= 3220251 | pmc=1203496 }}
  • {{cite journal | vauthors=Warner TF, Azen EA |title=Proline-rich proteins are present in serous cells of submucosal glands in the respiratory tract |journal=Am. Rev. Respir. Dis. |volume=130 |issue= 1 |pages= 115–8 |year= 1984 |pmid= 6377992 |doi= 10.1164/arrd.1984.130.1.115|doi-broken-date=1 November 2024 }}
  • {{cite journal | vauthors=Saitoh E, Isemura S, Sanada K |title=Complete amino acid sequence of a basic proline-rich peptide, P-D, from human parotid saliva |journal=J. Biochem. |volume=93 |issue= 2 |pages= 495–502 |year= 1983 |pmid= 6841349 |doi=10.1093/jb/93.3.883 }}
  • {{cite journal | vauthors=Kauffman DL, Keller PJ, Bennick A, Blum M |title=Alignment of amino acid and DNA sequences of human proline-rich proteins |journal=Crit. Rev. Oral Biol. Med. |volume=4 |issue= 3–4 |pages= 287–92 |year= 1993 |pmid= 8373986 |doi= 10.1177/10454411930040030501|doi-access=free }}
  • {{cite journal |vauthors=Kim HS, Lyons KM, Saitoh E, etal |title=The structure and evolution of the human salivary proline-rich protein gene family |journal=Mamm. Genome |volume=4 |issue= 1 |pages= 3–14 |year= 1993 |pmid= 8422499 |doi=10.1007/BF00364656 |s2cid=24058984 }}
  • {{cite journal |vauthors=Azen EA, Amberger E, Fisher S, etal |title=PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins |journal=Am. J. Hum. Genet. |volume=58 |issue= 1 |pages= 143–53 |year= 1996 |pmid= 8554050 | pmc=1914931 }}
  • {{cite journal | vauthors=Castle AM, Castle JD |title=Enhanced Glycosylation and Sulfation of Secretory Proteoglycans Is Coupled to the Expression of a Basic Secretory Protein |journal=Mol. Biol. Cell |volume=9 |issue= 3 |pages= 575–83 |year= 1998 |pmid= 9487127 |doi= 10.1091/mbc.9.3.575| pmc=25286 }}
  • {{cite journal | vauthors=Chan M, Bennick A |title=Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases |journal=Eur. J. Biochem. |volume=268 |issue= 12 |pages= 3423–31 |year= 2001 |pmid= 11422372 |doi=10.1046/j.1432-1327.2001.02241.x |doi-access=free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Vallat JM, Magy L, Lagrange E, etal |title=Diagnostic value of ultrastructural nerve examination in Charcot-Marie-Tooth disease: two CMT 1B cases with pseudo-recessive inheritance |journal=Acta Neuropathol. |volume=113 |issue= 4 |pages= 443–9 |year= 2007 |pmid= 17294201 |doi= 10.1007/s00401-007-0196-7 |s2cid=42561185 }}

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Category:Precursor proteins

Category:Salivary proline-rich proteins

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