PRDX6
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Peroxiredoxin-6 is a protein that in humans is encoded by the PRDX6 gene.{{cite journal | vauthors = Phelan SA | title = AOP2 (antioxidant protein 2): structure and function of a unique thiol-specific antioxidant | journal = Antioxidants & Redox Signaling | volume = 1 | issue = 4 | pages = 571–584 | date = Mar 2001 | pmid = 11233154 | doi = 10.1089/ars.1999.1.4-571 | url = https://digitalcommons.fairfield.edu/cgi/viewcontent.cgi?article=1001&context=biology-facultypubs | url-access = subscription }}{{cite web | title = Entrez Gene: PRDX6 peroxiredoxin 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9588}} It is a member of the peroxiredoxin family of antioxidant enzymes. Peroxiredoxin 6 is widely distributed in several organs, especially the lungs.{{Cite journal |last1=Jia |first1=Wenhui |last2=Dong |first2=Chunling |last3=Li |first3=Bo |date=January 2023 |title=Anti-Oxidant and Pro-Oxidant Effects of Peroxiredoxin 6: A Potential Target in Respiratory Diseases |journal=Cells |language=en |volume=12 |issue=1 |pages=181 |doi=10.3390/cells12010181 |issn=2073-4409 |pmc=9818991 |pmid=36611974 |doi-access=free}}
Function
The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.
References
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Further reading
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- {{cite journal | vauthors = Manevich Y, Fisher AB | title = Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid metabolism | journal = Free Radical Biology & Medicine | volume = 38 | issue = 11 | pages = 1422–1432 | date = June 2005 | pmid = 15890616 | doi = 10.1016/j.freeradbiomed.2005.02.011 }}
- {{cite journal | vauthors = Akesson B | title = Work in progress. {{as written|Occu|rence [sic]}} of phospholipase A1 and A2 in human decidua | journal = Prostaglandins | volume = 9 | issue = 5 | pages = 667–673 | date = May 1975 | pmid = 240188 | doi = 10.1016/0090-6980(75)90106-9 }}
- {{cite journal | vauthors = Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R | display-authors = 6 | title = Human liver protein map: a reference database established by microsequencing and gel comparison | journal = Electrophoresis | volume = 13 | issue = 12 | pages = 992–1001 | date = December 1992 | pmid = 1286669 | doi = 10.1002/elps.11501301201 | s2cid = 23518983 }}
- {{cite journal | vauthors = Dawson SJ, White LA | title = Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin | journal = The Journal of Infection | volume = 24 | issue = 3 | pages = 317–320 | date = May 1992 | pmid = 1602151 | doi = 10.1016/S0163-4453(05)80037-4 }}
- {{cite journal | vauthors = Yeats DA, Bakhle YS | title = Phospholipases A2 and C of human lung; subcellular distribution and substrate selectivity | journal = Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | volume = 1003 | issue = 2 | pages = 189–195 | date = June 1989 | pmid = 2730891 | doi = 10.1016/0005-2760(89)90254-3 }}
- {{cite journal | vauthors = Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H | display-authors = 6 | title = Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 2 | issue = 1 | pages = 37–43 | year = 1995 | pmid = 7788527 | doi = 10.1093/dnares/2.1.37 | doi-access = free }}
- {{cite journal | vauthors = Golaz O, Hughes GJ, Frutiger S, Paquet N, Bairoch A, Pasquali C, Sanchez JC, Tissot JD, Appel RD, Walzer C | display-authors = 6 | title = Plasma and red blood cell protein maps: update 1993 | journal = Electrophoresis | volume = 14 | issue = 11 | pages = 1223–1231 | date = November 1993 | pmid = 8313871 | doi = 10.1002/elps.11501401183 | s2cid = 21447827 }}
- {{cite journal | vauthors = Kim TS, Sundaresh CS, Feinstein SI, Dodia C, Skach WR, Jain MK, Nagase T, Seki N, Ishikawa K, Nomura N, Fisher AB | display-authors = 6 | title = Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein | journal = The Journal of Biological Chemistry | volume = 272 | issue = 4 | pages = 2542–2550 | date = January 1997 | pmid = 8999971 | doi = 10.1074/jbc.272.4.2542 | doi-access = free }}
- {{cite journal | vauthors = Frank S, Munz B, Werner S | title = The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene | journal = Oncogene | volume = 14 | issue = 8 | pages = 915–921 | date = February 1997 | pmid = 9050990 | doi = 10.1038/sj.onc.1200905 | s2cid = 23889845 | doi-access = }}
- {{cite journal | vauthors = Kang SW, Baines IC, Rhee SG | title = Characterization of a mammalian peroxiredoxin that contains one conserved cysteine | journal = The Journal of Biological Chemistry | volume = 273 | issue = 11 | pages = 6303–6311 | date = March 1998 | pmid = 9497358 | doi = 10.1074/jbc.273.11.6303 | doi-access = free }}
- {{cite journal | vauthors = Choi HJ, Kang SW, Yang CH, Rhee SG, Ryu SE | title = Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution | journal = Nature Structural Biology | volume = 5 | issue = 5 | pages = 400–406 | date = May 1998 | pmid = 9587003 | doi = 10.1038/nsb0598-400 | s2cid = 10737259 }}
- {{cite journal | vauthors = Chen JW, Dodia C, Feinstein SI, Jain MK, Fisher AB | title = 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities | journal = The Journal of Biological Chemistry | volume = 275 | issue = 37 | pages = 28421–28427 | date = September 2000 | pmid = 10893423 | doi = 10.1074/jbc.M005073200 | doi-access = free }}
- {{cite journal | vauthors = Fatma N, Singh DP, Shinohara T, Chylack LT | title = Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress | journal = The Journal of Biological Chemistry | volume = 276 | issue = 52 | pages = 48899–48907 | date = December 2001 | pmid = 11677226 | doi = 10.1074/jbc.M100733200 | doi-access = free }}
- {{cite journal | vauthors = Wagner E, Luche S, Penna L, Chevallet M, Van Dorsselaer A, Leize-Wagner E, Rabilloud T | title = A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress | journal = The Biochemical Journal | volume = 366 | issue = Pt 3 | pages = 777–785 | date = September 2002 | pmid = 12059788 | pmc = 1222825 | doi = 10.1042/BJ20020525 }}
- {{cite journal | vauthors = Leavey PJ, Gonzalez-Aller C, Thurman G, Kleinberg M, Rinckel L, Ambruso DW, Freeman S, Kuypers FA, Ambruso DR | display-authors = 6 | title = A 29-kDa protein associated with p67phox expresses both peroxiredoxin and phospholipase A2 activity and enhances superoxide anion production by a cell-free system of NADPH oxidase activity | journal = The Journal of Biological Chemistry | volume = 277 | issue = 47 | pages = 45181–45187 | date = November 2002 | pmid = 12121978 | doi = 10.1074/jbc.M202869200 | doi-access = free }}
- {{cite journal | vauthors = Manevich Y, Sweitzer T, Pak JH, Feinstein SI, Muzykantov V, Fisher AB | title = 1-Cys peroxiredoxin overexpression protects cells against phospholipid peroxidation-mediated membrane damage | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 18 | pages = 11599–11604 | date = September 2002 | pmid = 12193653 | pmc = 129315 | doi = 10.1073/pnas.182384499 | doi-access = free | bibcode = 2002PNAS...9911599M }}
- {{cite journal | vauthors = Krapfenbauer K, Engidawork E, Cairns N, Fountoulakis M, Lubec G | title = Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders | journal = Brain Research | volume = 967 | issue = 1–2 | pages = 152–160 | date = March 2003 | pmid = 12650976 | doi = 10.1016/S0006-8993(02)04243-9 | s2cid = 854144 }}
- {{cite journal | vauthors = Kuda O, Brezinova M, Silhavy J, Landa V, Zidek V, Dodia C, Kreuchwig F, Vrbacky M, Balas L, Durand T, Hübner N, Fisher AB, Kopecky J, Pravenec M | display-authors = 6 | title = Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis of Palmitic Acid Ester of 9-Hydroxystearic Acid | journal = Diabetes | volume = 67 | issue = 6 | pages = 1190–1199 | date = June 2018 | pmid = 29549163 | pmc = 6463562 | doi = 10.2337/db17-1087 }}
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{{Peroxidases}}
{{Enzymes}}
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